ID   F1MM05_BOVIN            Unreviewed;       670 AA.
AC   F1MM05;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   04-NOV-2026, entry version 88.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog {ECO:0000256|ARBA:ARBA00017198};
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog {ECO:0000256|ARBA:ARBA00030523};
GN   Name=MAU2 {ECO:0000313|Ensembl:ENSBTAP00000008054.6,
GN   ECO:0000313|VGNC:VGNC:31267};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000008054.6, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000008054.6}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008054.6};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000008054.6}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008054.6};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- SUBUNIT: Heterodimerizes with MAU2/SCC2 to form the cohesin loading
CC       complex. The NIPBL-MAU2 heterodimer interacts with the SMC1A-SMC3
CC       heterodimer and with the cohesin complex composed of SMC1A, SMC3, RAD21
CC       and STAG1. Interacts with PRR12. {ECO:0000256|ARBA:ARBA00094868}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family.
CC       {ECO:0000256|ARBA:ARBA00008585}.
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DR   AlphaFoldDB; F1MM05; -.
DR   FunCoup; F1MM05; 5943.
DR   STRING; 9913.ENSBTAP00000008054; -.
DR   PaxDb; 9913-ENSBTAP00000008054; -.
DR   Ensembl; ENSBTAT00000008054.7; ENSBTAP00000008054.6; ENSBTAG00000006124.7.
DR   VEuPathDB; HostDB:ENSBTAG00000006124; -.
DR   VGNC; VGNC:31267; MAU2.
DR   eggNOG; KOG2300; Eukaryota.
DR   GeneTree; ENSGT00390000012198; -.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; F1MM05; -.
DR   OMA; AAEMQFT; -.
DR   OrthoDB; 5565328at2759; -.
DR   Reactome; R-BTA-2470946; Cohesin Loading onto Chromatin.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000006124; Expressed in thymus and 105 other cell types or tissues.
DR   ExpressionAtlas; F1MM05; baseline.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; IBA:GO_Central.
DR   GO; GO:0061775; F:cohesin loader activity; IBA:GO_Central.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; IBA:GO_Central.
DR   FunFam; 1.25.40.10:FF:000216; MAU2 chromatid cohesion factor homolog; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_rpt.
DR   PANTHER; PTHR21394; MAU2 CHROMATID COHESION FACTOR HOMOLOG; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; TPR-like; 2.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
SQ   SEQUENCE   670 AA;  75680 MW;  F06007607DA0C8DD CRC64;
     MSPFLRPSWS RRHFKHKLHT PGCFVQQLSR ERRGAPAPPH APVSASLWRR LVVVEAKMAA
     QAAAAAQAAA AQAAQAEAAE SWYLALLGFA EHFRTSSPPK IRLCVHCLQA VFPFKPPQRI
     EARTHLQLGS VLYHHTKNSE QARSHLEKAW LISQQITQFE DVKFEAASLL SELYCQENSV
     DAAKPLLRKA IQISQQTPYW HCRLLFQLAQ LHTLEKDLVS ACDLLGVGAE YARVVGSEYT
     RALFLLSKGM LLLMERKLQE VHPLLTLCGQ IVENWQGNPI QKESLRVFFL VLQVTHYLDA
     GQVKSVKPCL KQLQQCIQTI STLHDDEILP SNPADLFHWL PKEHMCVLVY LVTVMHSMQA
     GYLEKAQKYT DKALMQLEKL KMLDCSPILS SFQVILLEHI IMCRLVTGHK ATALQEISQV
     CQLCQQSPRL FSNHAAQLHT LLGLYCVSVN CMDNAEAQFT TALRLTNHQE LWAFIVTNLA
     SVYIREGNRH QEVLYSLLER INPDHSFPVS SHCLRAAAFY VRGLFSFFQG RYNEAKRFLR
     ETLKMSNAED LNRLTACSLV LLGHIFYVLG NHRESNNMVV PAMQLASKIP DMSVQLWSSA
     LLRDLNKACG NAMDAHEAAQ MHQNFSQQLL QDHIEACSLP EHNLITWTDG PPPVQFQAQN
     GPNTSLASLL
//