ID   F1MB19_BOVIN            Unreviewed;       920 AA.
AC   F1MB19;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2024, sequence version 3.
DT   04-NOV-2026, entry version 80.
DE   RecName: Full=Neuronal PAS domain-containing protein 3 {ECO:0000256|ARBA:ARBA00070615};
DE   AltName: Full=Basic-helix-loop-helix-PAS protein MOP6 {ECO:0000256|ARBA:ARBA00078434};
DE   AltName: Full=Member of PAS protein 6 {ECO:0000256|ARBA:ARBA00083650};
GN   Name=NPAS3 {ECO:0000313|Ensembl:ENSBTAP00000005853.7,
GN   ECO:0000313|VGNC:VGNC:59355};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005853.7, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000005853.7}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005853.7};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000005853.7}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005853.7};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- FUNCTION: May play a broad role in neurogenesis. May control regulatory
CC       pathways relevant to schizophrenia and to psychotic illness.
CC       {ECO:0000256|ARBA:ARBA00059012}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH-
CC       PAS protein. Interacts with ARNT; forms a heterodimer that binds core
CC       DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE)
CC       of target gene promoters. {ECO:0000256|ARBA:ARBA00096451}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00981}.
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DR   RefSeq; XP_059735414.1; XM_059879431.1.
DR   AlphaFoldDB; F1MB19; -.
DR   Ensembl; ENSBTAT00000005853.7; ENSBTAP00000005853.7; ENSBTAG00000004462.7.
DR   GeneID; 527053; -.
DR   CTD; 64067; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004462; -.
DR   VGNC; VGNC:59355; NPAS3.
DR   eggNOG; KOG3558; Eukaryota.
DR   GeneTree; ENSGT00940000158051; -.
DR   HOGENOM; CLU_009542_1_0_1; -.
DR   OrthoDB; 6021714at2759; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000004462; Expressed in oocyte and 41 other cell types or tissues.
DR   ExpressionAtlas; F1MB19; baseline.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR   CDD; cd19732; bHLH-PAS_NPAS3_PASD6; 1.
DR   CDD; cd00130; PAS; 2.
DR   FunFam; 3.30.450.20:FF:000021; Neuronal PAS domain-containing protein 3; 1.
DR   FunFam; 3.30.450.20:FF:000091; Neuronal PAS domain-containing protein 3; 1.
DR   FunFam; 4.10.280.10:FF:000007; single-minded homolog 1 isoform X1; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF30; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF23171; bHLH_HIF1A; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00981}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE-
KW   ProRule:PRU00981};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PROSITE-ProRule:PRU00981}.
FT   DOMAIN          21..74
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          140..204
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          321..376
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          35..74
FT                   /note="Helix-loop-helix motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00981"
FT   REGION          204..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..11
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..238
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..472
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..528
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..560
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..584
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..606
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..675
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        732..746
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..766
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   920 AA;  99534 MW;  6DC9C8AA11133A72 CRC64;
     MAPTKPSFQQ DPSRRERLQA LRKEKSRDAA RSRRGKENFE FYELAKLLPL PAAITSQLDK
     ASIIRLTISY LKMRDFANQG DPPWNLRMEG PPPNTSVKGI QLWKSELCMR KTPCEVIGAQ
     RRRSPSALAI EVFEAHLGSH ILQSLDGFVF ALNQEGKFLY ISETVSIYLG LSQVELTGSS
     VFDYVHPGDH VEMAEQLGMK LPPGRGLLSQ GTAEDGASSA SSSSQSETPE PVESTSPSLL
     TTDNTLERSF FIRMKSTLTK RGVHIKSSGY KVIHITGRLR LRVSLSHGRT VPSQIMGLVV
     VAHALPPPTI NEVRIDCHMF VTRVNMDLNI IYCENRISDY MDLTPVDIVG KRCYHFIHAE
     DVEGIRHSHL DLLNKGQCVT KYYRWMQKNG GYIWIQSSAT IAINAKNANE KNIIWVNYLL
     SNPEYKDTPM DIAQLPHLPE KTSESSETSD SESDSKDTSE DNENSKSDEK GNQSENSEDP
     EPDRKKSGNT CDDDMHCNDD GHSCSNPDSR DSDDSFEHSD FENPKAAEDG GGGGFGALGR
     MQIKVERGYV ESESDLRLQD CESLSSDSAK DSDSAGEAGA QASSKHQKRK KRRKRQKGGS
     ASRRRLSSAS SPGGLDAGLV EPPRLLSSPN SASVLKIKTE ISEPINFDND SSIWNYPPNR
     EISRNESPYS MTKPPSSEHF PSPPGGGAGA GGLHVAIPDS VLTPPGADGT SSSATATARK
     TQFGTSAPAA LAPVASDPLS PPLSASPRDK HPGGGSGNGN GGGGPGTANS LLYTGDLEAL
     QRLQAGNVVL PLVHRVTGTL AATSTAAQRV YTTGTIRYAP AEVTLAMQGN LLPNAHAVNF
     VDVNSPGFGL DPKTPMEMLY HHVHRLNMSG PFGGAVSAAG LTQMPAGNVF TTAEGLFSTL
     PFPVYSNGIH AAQTLERKED
//