ID   F1M656_RAT              Unreviewed;       503 AA.
AC   F1M656;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   08-OCT-2025, sequence version 5.
DT   04-NOV-2026, entry version 97.
DE   RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN   Name=Tulp3 {ECO:0000313|Ensembl:ENSRNOP00000007634.6,
GN   ECO:0000313|RGD:1585259};
GN   Synonyms=LOC100364088 {ECO:0000313|RGD:1585259,
GN   ECO:0000313|RGD:2321769};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007634.6, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000007634.6}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007634.6};
RA   Doris P.A., Kalbfleisch T., Li K., Howe K., Wood J.;
RT   "GRCr8: a new rat reference genome assembly contstructed from accurate long
RT   reads and long range scaffolding.";
RL   Submitted (JAN-2024) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000007634.6}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007634.6};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC       ECO:0000256|RuleBase:RU361125}.
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DR   AlphaFoldDB; F1M656; -.
DR   FunCoup; F1M656; 1056.
DR   STRING; 10116.ENSRNOP00000007634; -.
DR   GlyGen; F1M656; 2 sites.
DR   PhosphoSitePlus; F1M656; -.
DR   PaxDb; 10116-ENSRNOP00000007634; -.
DR   Ensembl; ENSRNOT00000007634.8; ENSRNOP00000007634.6; ENSRNOG00000005767.9.
DR   AGR; RGD:1585259; -.
DR   RGD; 2321769; LOC100364088.
DR   RGD; 1585259; Tulp3.
DR   eggNOG; KOG2502; Eukaryota.
DR   GeneTree; ENSGT00940000158155; -.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OrthoDB; 8775810at2759; -.
DR   Reactome; R-RNO-5610787; Hedgehog 'off' state.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000005767; Expressed in ovary and 19 other cell types or tissues.
DR   ExpressionAtlas; F1M656; baseline and differential.
DR   GO; GO:0097731; C:9+0 non-motile cilium; ISO:RGD.
DR   GO; GO:0005930; C:axoneme; ISO:RGD.
DR   GO; GO:0097546; C:ciliary base; ISO:RGD.
DR   GO; GO:0035869; C:ciliary transition zone; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0005730; C:nucleolus; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:RGD.
DR   GO; GO:0120160; F:intraciliary transport particle A binding; ISO:RGD.
DR   GO; GO:1902121; F:lithocholic acid binding; ISO:RGD.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISO:RGD.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0060348; P:bone development; ISO:RGD.
DR   GO; GO:0007420; P:brain development; ISO:RGD.
DR   GO; GO:0060434; P:bronchus morphogenesis; ISO:RGD.
DR   GO; GO:0042149; P:cellular response to glucose starvation; ISO:RGD.
DR   GO; GO:0021953; P:central nervous system neuron differentiation; ISO:RGD.
DR   GO; GO:0021904; P:dorsal/ventral neural tube patterning; ISO:RGD.
DR   GO; GO:0031076; P:embryonic camera-type eye development; ISO:RGD.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; ISO:RGD.
DR   GO; GO:0061548; P:ganglion development; ISO:RGD.
DR   GO; GO:0035720; P:intraciliary anterograde transport; ISO:RGD.
DR   GO; GO:0060173; P:limb development; ISO:RGD.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; ISO:RGD.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISO:RGD.
DR   GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR   GO; GO:0021915; P:neural tube development; ISO:RGD.
DR   GO; GO:0001841; P:neural tube formation; ISO:RGD.
DR   GO; GO:0061512; P:protein localization to cilium; ISO:RGD.
DR   GO; GO:0097499; P:protein localization to non-motile cilium; ISO:RGD.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   FunFam; 3.20.90.10:FF:000001; Tubby-like protein; 1.
DR   Gene3D; 3.20.90.10; Tubby Protein, Chain A; 1.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   InterPro; IPR005398; Tubby_N.
DR   PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR   PANTHER; PTHR16517:SF138; TUBBY-RELATED PROTEIN 3; 1.
DR   Pfam; PF01167; Tub; 1.
DR   Pfam; PF16322; Tub_N; 2.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   PRINTS; PR01574; TUBBYPROTEIN.
DR   SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          70..121
FT                   /note="Tubby N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16322"
FT   DOMAIN          124..233
FT                   /note="Tubby N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16322"
FT   DOMAIN          255..498
FT                   /note="Tubby C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01167"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..13
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..205
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  55240 MW;  50404FF7BDE5F714 CRC64;
     MGVGDSAGCG CQGRGPTSSI LSSRAAASWG LDADATGRAG MEAARCAPGS RGDSAFEDET
     LRLRQLKLDN QRALLEKKQR KKRLEPLMVQ PNPEARLRRL KPRGSEEHTP LVDPQTPCSD
     VILHGIDGPA AFLKPEAQDL ESKPQVLSVG SSPTPEEGTE GSADGESPVE TASKPDLQEI
     LQKHGILSSV NYDEEPDEEA EDEGENLSSL PAQSEKESAG ASQKAASDTG ASGMTAQQGD
     AQLGEVENLE DFAYSPAPRG VTVKCRVTRD KKGMDRGLFP TYYMHLEKEE NRKIFLLAGR
     KRKKSKTSNY LVSTDPTDLS REGESYIGKL RSNLMGTKFT VYDHGVNPVK AQGLVEKAHT
     RQELAAICYE TNVLGFKGPR KMSVIIPGMN MNHERIPFRP RNEHESLLSK WQNKSMENLI
     ELHNKAPVWN DDTQSYVLNF HGRVTQASVK NFQIVHGNDP DYIVMQFGRV ADDVFTLDYN
     YPLCALQAFA IGLSSFDSKL ACE
//