ID   F1LSJ6_RAT              Unreviewed;       213 AA.
AC   F1LSJ6;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   04-NOV-2026, entry version 77.
DE   RecName: Full=Mitochondrial peptide methionine sulfoxide reductase {ECO:0000256|ARBA:ARBA00067384};
DE            EC=1.8.4.11 {ECO:0000256|ARBA:ARBA00012502};
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase {ECO:0000256|ARBA:ARBA00030643};
DE   AltName: Full=Protein-methionine-S-oxide reductase {ECO:0000256|ARBA:ARBA00030273};
GN   Name=Msra {ECO:0000313|Ensembl:ENSRNOP00000016616.7,
GN   ECO:0000313|RGD:70979};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000016616.7, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000016616.7}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000016616.7};
RA   Doris P.A., Kalbfleisch T., Li K., Howe K., Wood J.;
RT   "GRCr8: a new rat reference genome assembly contstructed from accurate long
RT   reads and long range scaffolding.";
RL   Submitted (JAN-2024) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000016616.7}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000016616.7};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the reversible oxidation-reduction of methionine
CC       sulfoxide in proteins to methionine. Has an important function as a
CC       repair enzyme for proteins that have been inactivated by oxidation.
CC       Plays a crucial role in repairing oxidized methionine residues in key
CC       lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c
CC       (CYCS), thereby restoring their function and maintaining lens
CC       transparency. {ECO:0000256|ARBA:ARBA00094335}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-
CC         methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol;
CC         Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700,
CC         Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120,
CC         ChEBI:CHEBI:50058; EC=1.8.4.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00047806};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + L-methionine + H2O = L-methionine
CC         (S)-S-oxide + [thioredoxin]-dithiol; Xref=Rhea:RHEA:19993, Rhea:RHEA-
CC         COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:58772; EC=1.8.4.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00048782};
CC   -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
CC       {ECO:0000256|ARBA:ARBA00005591}.
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DR   AlphaFoldDB; F1LSJ6; -.
DR   PeptideAtlas; F1LSJ6; -.
DR   Ensembl; ENSRNOT00000016616.8; ENSRNOP00000016616.7; ENSRNOG00000012440.10.
DR   RGD; 70979; Msra.
DR   VEuPathDB; HostDB:ENSRNOG00000012440; -.
DR   GeneTree; ENSGT00390000003823; -.
DR   HOGENOM; CLU_031040_10_3_1; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000012440; Expressed in adult mammalian kidney and 19 other cell types or tissues.
DR   ExpressionAtlas; F1LSJ6; baseline and differential.
DR   GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:InterPro.
DR   FunFam; 3.30.1060.10:FF:000001; Peptide methionine sulfoxide reductase MsrA; 1.
DR   Gene3D; 3.30.1060.10; Peptide methionine sulphoxide reductase MsrA; 1.
DR   HAMAP; MF_01401; MsrA; 1.
DR   InterPro; IPR002569; Met_Sox_Rdtase_MsrA_dom.
DR   InterPro; IPR036509; Met_Sox_Rdtase_MsrA_sf.
DR   InterPro; IPR050162; MsrA_MetSO_reductase.
DR   NCBIfam; TIGR00401; msrA; 1.
DR   PANTHER; PTHR42799; MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE; 1.
DR   PANTHER; PTHR42799:SF2; MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   SUPFAM; SSF55068; Peptide methionine sulfoxide reductase; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1LSJ6};
KW   Redox-active center {ECO:0000256|ARBA:ARBA00023284};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          65..179
FT                   /note="Peptide methionine sulphoxide reductase MsrA"
FT                   /evidence="ECO:0000259|Pfam:PF01625"
SQ   SEQUENCE   213 AA;  23691 MW;  CC9726AD1745D78B CRC64;
     MLSASRRTLQ LLSSSIPVRM MGDSSSKVIS AEEALPGRTE SIPVAAKHHV SGNRTVEPFP
     EGTQMAVFGM GCFWGAERKF WLLKGVYSTQ VGFAGGYTRN PTYKEVCSEK TGHAEVVRVV
     YRPEHVSFEE LLKVFWENHD PTQGMRQGND CGTQYRSAVY PTSAVQMEAA LKSKEEYQKL
     IKIISDWLPP RLGLWNDIGT QSQPHTDLHG GTA
//