ID PEX5R_HUMAN Reviewed; 626 AA. AC Q8IYB4; B7Z2A5; B7Z305; B7Z318; B7Z5Z5; B7Z8P2; E7EUV8; E7EUZ0; E9PEC1; AC E9PH97; Q9NQD1; Q9P2U3; Q9P2U4; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2004, sequence version 2. DT 02-SEP-2026, entry version 183. DE RecName: Full=PEX5-related protein; DE AltName: Full=PEX2-related protein; DE AltName: Full=PEX5-like protein; DE AltName: Full=Peroxin-5-related protein; DE AltName: Full=Peroxisome biogenesis factor 5-like; DE AltName: Full=Tetratricopeptide repeat-containing Rab8b-interacting protein; DE Short=Pex5Rp; DE Short=TRIP8b; GN Name=PEX5L; Synonyms=PEX5R, PXR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RA Sano H., Snider J., Ohta M.; RT "A novel peroxisomal targeting signal 1 receptor-like gene, PXR2, RT preferentially expressed in brain."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5; 6; 7 AND 8). RC TISSUE=Amygdala, Brain, Corpus callosum, and Kidney; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 264-626, SUBCELLULAR LOCATION, TISSUE RP SPECIFICITY, AND POSSIBLE INTERACTION WITH PTS1 PROTEINS. RC TISSUE=Liver; RX PubMed=11463335; DOI=10.1042/0264-6021:3570635; RA Amery L., Sano H., Mannaerts G.P., Snider J., Van Looy J., Fransen M., RA Van Veldhoven P.P.; RT "Identification of PEX5p-related novel peroxisome-targeting signal 1 RT (PTS1)-binding proteins in mammals."; RL Biochem. J. 357:635-646(2001). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] THR-226. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Accessory subunit of hyperpolarization-activated cyclic CC nucleotide-gated (HCN) channels, regulating their cell-surface CC expression and cyclic nucleotide dependence. CC {ECO:0000250|UniProtKB:Q8C437}. CC -!- SUBUNIT: Interacts with RAB8B. Forms an obligate 4:4 complex with HCN2 CC (By similarity). May interact with the C-terminal PTS1-type tripeptide CC peroxisomal targeting signal (SKL-type); the relevance of such CC interaction is however unclear (PubMed:11463335). Interacts with HCN3 CC (By similarity). Interacts with HCN4 with a 4:4 HCN4:PEX5L CC stoichiometry; reduces the effects of cAMP on the voltage-dependence CC and rate of activation of HCN4 (By similarity). CC {ECO:0000250|UniProtKB:Q8C437, ECO:0000250|UniProtKB:Q925N3, CC ECO:0000269|PubMed:11463335}. CC -!- INTERACTION: CC Q8IYB4-6; O88703: Hcn2; Xeno; NbExp=18; IntAct=EBI-16150786, EBI-771231; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; CC Peripheral membrane protein {ECO:0000250}. Note=Some fraction is CC membrane associated via its interaction with RAB8B. {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=8; CC Name=1; Synonyms=PXR2b; CC IsoId=Q8IYB4-1; Sequence=Displayed; CC Name=2; Synonyms=PXR2a; CC IsoId=Q8IYB4-2; Sequence=VSP_010435; CC Name=3; CC IsoId=Q8IYB4-3; Sequence=VSP_010436; CC Name=4; CC IsoId=Q8IYB4-4; Sequence=VSP_044743; CC Name=5; CC IsoId=Q8IYB4-5; Sequence=VSP_045136; CC Name=6; CC IsoId=Q8IYB4-6; Sequence=VSP_046977; CC Name=7; CC IsoId=Q8IYB4-7; Sequence=VSP_045136, VSP_046978; CC Name=8; CC IsoId=Q8IYB4-8; Sequence=VSP_046976; CC -!- TISSUE SPECIFICITY: Mainly expressed in brain. Also expressed in CC pancreas, testis and pituitary. {ECO:0000269|PubMed:11463335}. CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAC01120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB032592; BAA92878.1; -; mRNA. DR EMBL; AB032593; BAA92879.1; -; mRNA. DR EMBL; AK294501; BAH11791.1; -; mRNA. DR EMBL; AK295349; BAH12041.1; -; mRNA. DR EMBL; AK295386; BAH12054.1; -; mRNA. DR EMBL; AK299633; BAH13081.1; -; mRNA. DR EMBL; AK303716; BAH14028.1; -; mRNA. DR EMBL; AC007687; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090024; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092939; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471052; EAW78382.1; -; Genomic_DNA. DR EMBL; BC036183; AAH36183.2; -; mRNA. DR EMBL; AJ245503; CAC01120.1; ALT_INIT; mRNA. DR CCDS; CCDS3236.1; -. [Q8IYB4-1] DR CCDS; CCDS58861.1; -. [Q8IYB4-8] DR CCDS; CCDS58862.1; -. [Q8IYB4-7] DR CCDS; CCDS58863.1; -. [Q8IYB4-5] DR CCDS; CCDS58864.1; -. [Q8IYB4-4] DR CCDS; CCDS58865.1; -. [Q8IYB4-6] DR CCDS; CCDS58866.1; -. [Q8IYB4-2] DR CCDS; CCDS58867.1; -. [Q8IYB4-3] DR RefSeq; NP_001243679.1; NM_001256750.2. [Q8IYB4-2] DR RefSeq; NP_001243680.1; NM_001256751.2. [Q8IYB4-6] DR RefSeq; NP_001243681.1; NM_001256752.2. [Q8IYB4-3] DR RefSeq; NP_001243682.1; NM_001256753.2. [Q8IYB4-4] DR RefSeq; NP_001243683.1; NM_001256754.2. [Q8IYB4-5] DR RefSeq; NP_001243684.1; NM_001256755.2. [Q8IYB4-7] DR RefSeq; NP_001243685.1; NM_001256756.2. [Q8IYB4-8] DR RefSeq; NP_001336324.1; NM_001349395.2. [Q8IYB4-5] DR RefSeq; NP_001336328.1; NM_001349399.2. [Q8IYB4-8] DR RefSeq; NP_001336330.1; NM_001349401.2. [Q8IYB4-8] DR RefSeq; NP_001336333.1; NM_001349404.2. [Q8IYB4-8] DR RefSeq; NP_001336335.1; NM_001349406.2. [Q8IYB4-8] DR RefSeq; NP_001336337.1; NM_001349408.2. [Q8IYB4-8] DR RefSeq; NP_001336338.1; NM_001349409.2. [Q8IYB4-8] DR RefSeq; NP_001336339.1; NM_001349410.2. [Q8IYB4-8] DR RefSeq; NP_057643.1; NM_016559.3. [Q8IYB4-1] DR RefSeq; XP_011511193.1; XM_011512891.3. [Q8IYB4-8] DR RefSeq; XP_054202801.1; XM_054346826.1. [Q8IYB4-8] DR AlphaFoldDB; Q8IYB4; -. DR SMR; Q8IYB4; -. DR BioGRID; 119607; 9. DR DIP; DIP-58547N; -. DR FunCoup; Q8IYB4; 169. DR IntAct; Q8IYB4; 10. DR MINT; Q8IYB4; -. DR NDEx; IQUERY-CP-PEX5L; 1 NDEx IQuery Curated Pathway. DR STRING; 9606.ENSP00000419975; -. DR BindingDB; Q8IYB4; -. DR iPTMnet; Q8IYB4; -. DR PhosphoSitePlus; Q8IYB4; -. DR BioMuta; PEX5L; -. DR DMDM; 47606040; -. DR MassIVE; Q8IYB4; -. DR PaxDb; 9606-ENSP00000419975; -. DR PeptideAtlas; Q8IYB4; -. DR ProteomicsDB; 18507; -. DR ProteomicsDB; 18530; -. DR ProteomicsDB; 19857; -. DR ProteomicsDB; 20485; -. DR ProteomicsDB; 6966; -. DR ProteomicsDB; 71142; -. [Q8IYB4-1] DR ProteomicsDB; 71143; -. [Q8IYB4-2] DR ProteomicsDB; 71144; -. [Q8IYB4-3] DR ABCD; Q8IYB4; 4 sequenced antibodies. DR Antibodypedia; 54548; 50 antibodies from 17 providers. DR DNASU; 51555; -. DR Ensembl; ENST00000263962.12; ENSP00000263962.8; ENSG00000114757.19. [Q8IYB4-2] DR Ensembl; ENST00000392649.7; ENSP00000376420.3; ENSG00000114757.19. [Q8IYB4-7] DR Ensembl; ENST00000464614.5; ENSP00000417270.1; ENSG00000114757.19. [Q8IYB4-7] DR Ensembl; ENST00000465751.5; ENSP00000419348.1; ENSG00000114757.19. [Q8IYB4-6] DR Ensembl; ENST00000467460.6; ENSP00000419975.1; ENSG00000114757.19. [Q8IYB4-1] DR Ensembl; ENST00000468741.5; ENSP00000418665.1; ENSG00000114757.19. [Q8IYB4-8] DR Ensembl; ENST00000472994.5; ENSP00000418054.1; ENSG00000114757.19. [Q8IYB4-4] DR Ensembl; ENST00000476138.5; ENSP00000420555.1; ENSG00000114757.19. [Q8IYB4-5] DR Ensembl; ENST00000485199.5; ENSP00000418440.1; ENSG00000114757.19. [Q8IYB4-3] DR GeneID; 51555; -. DR KEGG; hsa:51555; -. DR MANE-Select; ENST00000467460.6; ENSP00000419975.1; NM_016559.3; NP_057643.1. DR UCSC; uc003fki.3; human. [Q8IYB4-1] DR AGR; HGNC:30024; -. DR ClinPGx; PA134892044; -. DR CTD; 51555; -. DR DisGeNET; 51555; -. DR GeneCards; PEX5L; -. DR HGNC; HGNC:30024; PEX5L. DR HPA; ENSG00000114757; Tissue enhanced (brain, parathyroid gland, retina). DR MIM; 611058; gene. DR OpenTargets; ENSG00000114757; -. DR VEuPathDB; HostDB:ENSG00000114757; -. DR eggNOG; KOG1125; Eukaryota. DR GeneTree; ENSGT00940000155931; -. DR HOGENOM; CLU_013516_5_0_1; -. DR InParanoid; Q8IYB4; -. DR OMA; RNWISES; -. DR OrthoDB; 10006023at2759; -. DR PAN-GO; Q8IYB4; 4 GO annotations based on evolutionary models. DR PhylomeDB; Q8IYB4; -. DR PathwayCommons; Q8IYB4; -. DR SignaLink; Q8IYB4; -. DR Agora; ENSG00000114757; -. DR BioGRID-ORCS; 51555; 12 hits in 1139 CRISPR screens. DR ChiTaRS; PEX5L; human. DR GenomeRNAi; 51555; -. DR Pharos; Q8IYB4; Tbio. DR PRO; PR:Q8IYB4; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q8IYB4; protein. DR Bgee; ENSG00000114757; Expressed in endothelial cell and 130 other cell types or tissues. DR ExpressionAtlas; Q8IYB4; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:UniProtKB. DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central. DR GO; GO:0043235; C:signaling receptor complex; IDA:MGI. DR GO; GO:0005052; F:peroxisome matrix targeting signal-1 binding; IDA:UniProtKB. DR GO; GO:0000268; F:peroxisome targeting sequence binding; IDA:UniProtKB. DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central. DR GO; GO:0031267; F:small GTPase binding; IPI:UniProtKB. DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IBA:GO_Central. DR GO; GO:0016561; P:protein import into peroxisome matrix, translocation; IBA:GO_Central. DR FunFam; 1.25.40.10:FF:000012; PEX5-related protein isoform 5; 1. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1. DR InterPro; IPR024111; PEX5/PEX5L. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_rpt. DR PANTHER; PTHR10130; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5; 1. DR PANTHER; PTHR10130:SF1; PEX5-RELATED PROTEIN; 1. DR Pfam; PF13432; TPR_16; 1. DR Pfam; PF13181; TPR_8; 2. DR SMART; SM00028; TPR; 5. DR SUPFAM; SSF48452; TPR-like; 1. DR PROSITE; PS50005; TPR; 5. DR PROSITE; PS50293; TPR_REGION; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cytoplasm; Membrane; Phosphoprotein; KW Proteomics identification; Reference proteome; Repeat; TPR repeat. FT CHAIN 1..626 FT /note="PEX5-related protein" FT /id="PRO_0000106317" FT REPEAT 326..359 FT /note="TPR 1" FT REPEAT 360..393 FT /note="TPR 2" FT REPEAT 395..427 FT /note="TPR 3" FT REPEAT 474..507 FT /note="TPR 4" FT REPEAT 509..541 FT /note="TPR 5" FT REPEAT 543..575 FT /note="TPR 6" FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 118..167 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 181..235 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 181..198 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 225..235 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 205 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8C437" FT MOD_RES 253 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q925N3" FT MOD_RES 257 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q925N3" FT MOD_RES 261 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8C437" FT MOD_RES 445 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8C437" FT MOD_RES 447 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8C437" FT VAR_SEQ 1..192 FT /note="Missing (in isoform 8)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046976" FT VAR_SEQ 1..43 FT /note="Missing (in isoform 5 and isoform 7)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_045136" FT VAR_SEQ 7..65 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044743" FT VAR_SEQ 7..30 FT /note="Missing (in isoform 6)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046977" FT VAR_SEQ 8..31 FT /note="KSKEQGYGKLSSDEDLEIIVDQKQ -> VVGVTLKKKWHCLQKSDLTLAL FT (in isoform 2)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_010435" FT VAR_SEQ 32..66 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_010436" FT VAR_SEQ 104..168 FT /note="Missing (in isoform 7)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046978" FT VARIANT 226 FT /note="A -> T (in a colorectal cancer sample; somatic FT mutation; dbSNP:rs146906651)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_035865" FT CONFLICT 88 FT /note="E -> K (in Ref. 2; BAH12041)" FT /evidence="ECO:0000305" FT CONFLICT 216 FT /note="S -> Y (in Ref. 5; AAH36183)" FT /evidence="ECO:0000305" FT CONFLICT 292 FT /note="R -> Q (in Ref. 2; BAH13081)" FT /evidence="ECO:0000305" FT CONFLICT 318 FT /note="H -> P (in Ref. 2; BAH11791)" FT /evidence="ECO:0000305" FT CONFLICT 409 FT /note="H -> Y (in Ref. 2; BAH12054)" FT /evidence="ECO:0000305" FT CONFLICT 474 FT /note="P -> T (in Ref. 5; AAH36183)" FT /evidence="ECO:0000305" SQ SEQUENCE 626 AA; 69697 MW; 07109ABE1B2314C1 CRC64; MYQGHMQKSK EQGYGKLSSD EDLEIIVDQK QGKGSRAADK AVAMVMKEIP REESAEEKPL LTMTSQLVNE QQESRPLLSP SIDDFLCETK SEAIARPVTS NTAVLTTGLD LLDLSEPVSQ TQTKAKKSEP SSKTSSLKKK ADGSDLISTD AEQRGQPLRV PETSSLDLDI QTQLEKWDDV KFHGDRNTKG HPMAERKSSS SRTGSKELLW SSEHRSQPEL SGGKSALNSE SASELELVAP TQARLTKEHR WGSALLSRNH SLEEEFERAK AAVESDTEFW DKMQAEWEEM ARRNWISENQ EAQNQVTISA SEKGYYFHTE NPFKDWPGAF EEGLKRLKEG DLPVTILFME AAILQDPGDA EAWQFLGITQ AENENEQAAI VALQRCLELQ PNNLKALMAL AVSYTNTGHQ QDACDALKNW IKQNPKYKYL VKSKKGSPGL TRRMSKSPVD SSVLEGVKEL YLEAAHQNGD MIDPDLQTGL GVLFHLSGEF NRAIDAFNAA LTVRPEDYSL WNRLGATLAN GDRSEEAVEA YTRALEIQPG FIRSRYNLGI SCINLGAYRE AVSNFLTALS LQRKSRNQQQ VPHPAISGNI WAALRIALSL MDQPELFQAA NLGDLDVLLR AFNLDP //