ID   E0VT04_PEDHC            Unreviewed;       471 AA.
AC   E0VT04;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   02-SEP-2026, entry version 74.
DE   SubName: Full=N-acetylgalactosamine kinase, putative {ECO:0000313|EnsemblMetazoa:PHUM424860-PA};
GN   Name=8230109 {ECO:0000313|EnsemblMetazoa:PHUM424860-PA};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Paraneoptera; Psocodea;
OC   Troctomorpha; Phthiraptera; Anoplura; Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|EnsemblMetazoa:PHUM424860-PA, ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|Proteomes:UP000009046}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M.,
RA   Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D.,
RA   Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A.,
RA   Walenz B., Tubio J.M., Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T.,
RA   Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E.,
RA   Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M.,
RA   Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M.,
RA   Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F.,
RA   Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A.,
RA   Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E.,
RA   Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J.,
RA   Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M.,
RA   Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:PHUM424860-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM424860-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC       {ECO:0000256|ARBA:ARBA00006566}.
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DR   EMBL; AAZO01005192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002429248.1; XM_002429203.1.
DR   AlphaFoldDB; E0VT04; -.
DR   STRING; 121224.E0VT04; -.
DR   EnsemblMetazoa; PHUM424860-RA; PHUM424860-PA; PHUM424860.
DR   KEGG; phu:Phum_PHUM424860; -.
DR   CTD; 8230109; -.
DR   VEuPathDB; VectorBase:PHUM424860; -.
DR   eggNOG; KOG0631; Eukaryota.
DR   HOGENOM; CLU_017814_6_2_1; -.
DR   OMA; GFHDTYF; -.
DR   OrthoDB; 187738at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004335; F:galactokinase activity; IEA:InterPro.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1440.340; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.3170; -; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_N.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR006206; Mevalonate/galactokinase.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00131; gal_kin; 1.
DR   PANTHER; PTHR10457:SF7; GALACTOKINASE-RELATED; 1.
DR   PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          30..77
FT                   /note="Galactokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10509"
FT   DOMAIN          121..203
FT                   /note="GHMP kinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00288"
FT   DOMAIN          370..441
FT                   /note="GHMP kinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08544"
SQ   SEQUENCE   471 AA;  52820 MW;  951E3F150188AF94 CRC64;
     MSDLNSVSEG NYPPVYPLPN DEDIITLTKY FKKKYNEEPD FYARAPGRVN LIGEHVDYCG
     YSVCPMAVQQ HVVIAFKLSD DSVVKISNVD ETYNSYECSI NDVNIPENVL PEWHFYFLCG
     VKGVLEKLPP ETTRRGFRAS VYGNIPLGSG LSSSSALVSA VTLALSRAYN LTLTKEELAD
     LAAKSERYIG TLGGGMDQAI SFLATKGCAK HISFDPLKST DLKLPDGALF VIAHSLIQMN
     KAATQDFNCR VVECRLACQV LAKRLRLDWK RINKLAFLQK SIGLGVRHLR ALATETLHEE
     PYTKDEICKE LQITQEELNK TSLTENTKHI QHFKLKQRML HVTEEVERVM EFIRICKEAE
     KGTMSSESAL YSLGKLLKKS HESLKNLYEC SHEELDKIIK LAENHTLGAR LTGAGWGGCT
     VALTAKDKVE DYIETLKEEF YRCNERAEDL DLDNLVFVTE PGNGAAIFIK S
//