ID   E0VBJ1_PEDHC            Unreviewed;       635 AA.
AC   E0VBJ1;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   02-SEP-2026, entry version 79.
DE   RecName: Full=Semaphorin-1A {ECO:0000256|ARBA:ARBA00074143};
DE   AltName: Full=Semaphorin-I {ECO:0000256|ARBA:ARBA00083066};
GN   Name=8231018 {ECO:0000313|EnsemblMetazoa:PHUM062540-PA};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Paraneoptera; Psocodea;
OC   Troctomorpha; Phthiraptera; Anoplura; Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|EnsemblMetazoa:PHUM062540-PA, ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|Proteomes:UP000009046}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M.,
RA   Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D.,
RA   Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A.,
RA   Walenz B., Tubio J.M., Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T.,
RA   Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E.,
RA   Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M.,
RA   Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M.,
RA   Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F.,
RA   Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A.,
RA   Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E.,
RA   Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J.,
RA   Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M.,
RA   Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:PHUM062540-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM062540-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the semaphorin family.
CC       {ECO:0000256|ARBA:ARBA00009492}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AAZO01000732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002423485.1; XM_002423440.1.
DR   AlphaFoldDB; E0VBJ1; -.
DR   STRING; 121224.E0VBJ1; -.
DR   EnsemblMetazoa; PHUM062540-RA; PHUM062540-PA; PHUM062540.
DR   KEGG; phu:Phum_PHUM062540; -.
DR   CTD; 8231018; -.
DR   VEuPathDB; VectorBase:PHUM062540; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   HOGENOM; CLU_009051_7_0_1; -.
DR   OMA; YEDYVFF; -.
DR   OrthoDB; 9988752at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0045499; F:chemorepellent activity; IEA:TreeGrafter.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:TreeGrafter.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:TreeGrafter.
DR   GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:TreeGrafter.
DR   CDD; cd11237; Sema_1A; 1.
DR   FunFam; 3.30.1680.10:FF:000016; Putative Semaphorin-6B; 1.
DR   FunFam; 2.130.10.10:FF:000346; Sema-1a, isoform D; 1.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR042068; SEM1A_sema_dom.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036:SF131; MIP07328P; 1.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        536..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..413
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   REGION          613..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..625
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   635 AA;  71117 MW;  95A9C8EC2409C681 CRC64;
     MFNFFLFFYF QRIEWHASRP HREICTLKGK SEDDCQNYIR VLAKISQDKL LICGSNAYKP
     YCRYYQYKNG EYVVVKDFEG GGLCPYDPDH NSTAVFTDGQ LYAATVADFQ GGDPLIYREP
     LRTERSDLKQ LNGPSFVSSV AYEDYVFFFF RETAVEYMNC GKKVYSRVAR VCKHDKGGPH
     QFGDRWTSFL KSRLNCSVPG DYPFYFDEIQ SMSEMVEGIY GQRSAQLMYG VFTTPINSIG
     GSAVCAFNMQ SILDTFEGPF KEQESMNSNW LPVPITKVPE PRPGQCVNDS RTLPDVSVNF
     VKSHTLMDYA VPAFFSRPVL IRISSQYRFT KVAVDPQVRT PDGRAYDVLF IGTDDGKVVK
     AVNSASFDSD DKVQTVVLEE IQILPPGIPV KNLYVANGNL IILTDDEIQS IPVHRCDNEN
     VTTCRSCVAL QDPYCAWDVL QKKCVASDLT VGWDGDKKRF LQSVTKGENK ACPHTGSPHS
     HGRTPGHFME ADLNNEIIIE LDESNVISDT LAGLSHPGAK LPSSQENMVI YTAETLGIAV
     ATSILGALVV GFIGGFLFSR RCRGDDYSDM PRFPDNQRHQ LNRLTDSGLN ADLPQHINNK
     AINLVLNVPP KNANGKNANS SAENKPIQKI KKTYI
//