ID   D8KAS8_NITWC            Unreviewed;       429 AA.
AC   D8KAS8;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   02-SEP-2026, entry version 77.
DE   SubName: Full=Dihydroorotase, multifunctional complex type {ECO:0000313|EMBL:ADJ29505.1};
GN   OrderedLocusNames=Nwat_2739 {ECO:0000313|EMBL:ADJ29505.1};
OS   Nitrosococcus watsoni (strain C-113).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Chromatiales; Chromatiaceae; Nitrosococcus.
OX   NCBI_TaxID=105559 {ECO:0000313|EMBL:ADJ29505.1, ECO:0000313|Proteomes:UP000000393};
RN   [1] {ECO:0000313|EMBL:ADJ29505.1, ECO:0000313|Proteomes:UP000000393}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C-113 {ECO:0000313|EMBL:ADJ29505.1,
RC   ECO:0000313|Proteomes:UP000000393};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Malfatti S.A., Chain P.S.G., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Cambell M.A., Heidelberg J.F., Klotz M.G., Woyke T.;
RT   "Complete sequence of chromosome of Nitrosococcus watsoni C-113.";
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002086; ADJ29505.1; -; Genomic_DNA.
DR   RefSeq; WP_013221571.1; NC_014315.1.
DR   AlphaFoldDB; D8KAS8; -.
DR   STRING; 105559.Nwat_2739; -.
DR   KEGG; nwa:Nwat_2739; -.
DR   eggNOG; COG0044; Bacteria.
DR   HOGENOM; CLU_015572_1_0_6; -.
DR   OrthoDB; 5687299at2; -.
DR   Proteomes; UP000000393; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0004038; F:allantoinase activity; IEA:TreeGrafter.
DR   GO; GO:0004151; F:dihydroorotase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006145; P:purine nucleobase catabolic process; IEA:TreeGrafter.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:InterPro.
DR   CDD; cd01317; DHOase_IIa; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR   InterPro; IPR013108; Amidohydro_3.
DR   InterPro; IPR004722; DHOase.
DR   InterPro; IPR050138; DHOase/Allantoinase_Hydrolase.
DR   InterPro; IPR024403; DHOase_cat.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; NF005791; PRK07627.1; 1.
DR   NCBIfam; TIGR00857; pyrC_multi; 1.
DR   PANTHER; PTHR43668; ALLANTOINASE; 1.
DR   PANTHER; PTHR43668:SF2; ALLANTOINASE; 1.
DR   Pfam; PF07969; Amidohydro_3; 1.
DR   Pfam; PF12890; DHOase; 1.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   4: Predicted;
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000393};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          51..236
FT                   /note="Dihydroorotase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF12890"
FT   DOMAIN          339..422
FT                   /note="Amidohydrolase 3"
FT                   /evidence="ECO:0000259|Pfam:PF07969"
SQ   SEQUENCE   429 AA;  46478 MW;  7941831A838C0D36 CRC64;
     MRTLIRGGRL IDPYNGIDGL QDLYLAEGRV IAIGSAPEDF RVEQTIDAQD QIVCPGLIDL
     QARLREPGQE QKGTIATETL AAAKGGITTL CCPPDTLAII DTPAVVDLIA HREAQYQRTR
     ILPLGALTQG LQGLQLAEMG ILQEAGCVGV SNGLMPITNS QVMRQAMEYA ATLGITLFLY
     PRDPWLGIEG CCHEGIVSAR LGLAGIPETA ETVSLARDLL LIEQTGVQAH FCHLSSARAV
     RMVRQAQTEG LPISADVTAY HLHLTEHDIG EFDSQCHVIP PLRTLRDRDA LHEGLREGTF
     SAICSDHQPH EVDAKLGAFP ITEPGISGLE TLLPLSLRLT QDDILTLPEV IAYLTCQPAQ
     VLGIEGGHLA PGQRADICIF DPHCHWIFKP EEMASQGKNT PFGGWEFQGR VTYTLLEGRV
     VFAAAAETL
//