ID   D6RIP1_MOUSE            Unreviewed;       498 AA.
AC   D6RIP1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   02-SEP-2026, entry version 92.
DE   SubName: Full=Polymerase (DNA directed), gamma {ECO:0000313|Ensembl:ENSMUSP00000119616.2};
GN   Name=Polg {ECO:0000313|Ensembl:ENSMUSP00000119616.2,
GN   ECO:0000313|MGI:MGI:1196389};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119616.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000119616.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119616.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000119616.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119616.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000119616.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119616.2};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; D6RIP1; -.
DR   SMR; D6RIP1; -.
DR   PeptideAtlas; D6RIP1; -.
DR   ProteomicsDB; 359272; -.
DR   Antibodypedia; 28558; 231 antibodies from 37 providers.
DR   Ensembl; ENSMUST00000149444.8; ENSMUSP00000119616.2; ENSMUSG00000039176.18.
DR   AGR; MGI:1196389; -.
DR   MGI; MGI:1196389; Polg.
DR   VEuPathDB; HostDB:ENSMUSG00000039176; -.
DR   GeneTree; ENSGT00390000000453; -.
DR   HOGENOM; CLU_547407_0_0_1; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000039176; Expressed in spermatocyte and 251 other cell types or tissues.
DR   ExpressionAtlas; D6RIP1; baseline and differential.
DR   GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   FunFam; 3.30.420.390:FF:000001; DNA polymerase gamma, catalytic subunit; 1.
DR   FunFam; 3.30.420.390:FF:000002; DNA polymerase gamma, catalytic subunit; 1.
DR   Gene3D; 3.30.420.390; -; 2.
DR   InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR   InterPro; IPR041336; DNApol_Exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR   PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR   Pfam; PF18136; DNApol_Exo; 1.
DR   PRINTS; PR00867; DNAPOLG.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D6RIP1,
KW   ECO:0007829|ProteomicsDB:D6RIP1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          104..396
FT                   /note="DNA mitochondrial polymerase exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF18136"
FT   REGION          30..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          299..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          420..447
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        300..317
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  56301 MW;  7EC4BFC233EB80CE CRC64;
     MSRLLWKKVA GAKVASGPVP ATARWVSSSV LDPVPSDGRP PSQMPSSENG QLRLNPLLIQ
     MLSRGLHEQI FGCGGEMPDE AAVQRSVEHL QKHGLWGQPA TPLPDVELRL PRLFGGNLDQ
     HFRLLAQKQS LPYLEAAASL LEAQLPPEPK SWAWAEGWTR YGPEGEAEPV AIPEERALVF
     DVEVCLAEGT CPTLAVAISP SAWYSWCSRR LVEERYSWTS QLSPADLIPL GGSTSASSST
     KQDGQEQLVV GHNVSFDRAH IREQYLIQDS RMRFLDTMSM HMAISGLSSF QRSLWMGAKQ
     GKHKTQQSTK RGQKSPRKAN GPAISSWDWM DISSANNLAD VHNLYVGGPP LEKEPRELFV
     KGSMRDIREN FQDLMQYCAR DVWATFEVFQ QQLPLFLERC PHPVTLAGML EMGVSYLPVN
     QNWERYLTEA QNTYEELQRE MKKSLMDLAN DACQLLSGER YKEDPWLWDL EWDLQEFKQK
     KAKKILARPA RRRSFSEV
//