ID D4DFE6_TRIVH Unreviewed; 535 AA. AC D4DFE6; DT 18-MAY-2010, integrated into UniProtKB/TrEMBL. DT 18-MAY-2010, sequence version 1. DT 02-SEP-2026, entry version 61. DE RecName: Full=Histone-lysine N-methyltransferase SET9 {ECO:0000256|ARBA:ARBA00015413}; DE EC=2.1.1.372 {ECO:0000256|ARBA:ARBA00024057}; DE AltName: Full=Histone-lysine N-methyltransferase set9 {ECO:0000256|ARBA:ARBA00014232}; DE AltName: Full=SET domain protein 9 {ECO:0000256|ARBA:ARBA00030653}; GN ORFNames=TRV_05893 {ECO:0000313|EMBL:EFE39408.1}; OS Trichophyton verrucosum (strain HKI 0517). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton. OX NCBI_TaxID=663202 {ECO:0000313|EMBL:EFE39408.1, ECO:0000313|Proteomes:UP000008383}; RN [1] {ECO:0000313|Proteomes:UP000008383} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HKI 0517 {ECO:0000313|Proteomes:UP000008383}; RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7; RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R., RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.; RT "Comparative and functional genomics provide insights into the RT pathogenicity of dermatophytic fungi."; RL Genome Biol. 12:R7.1-R7.16(2011). CC -!- FUNCTION: Histone methyltransferase that trimethylates 'Lys-20' of CC histone H4 to form H4K20me3. {ECO:0000256|ARBA:ARBA00001984}. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = CC N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L- CC homocysteine + 3 H(+); Xref=Rhea:RHEA:64456, Rhea:RHEA-COMP:15554, CC Rhea:RHEA-COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; CC EC=2.1.1.372; Evidence={ECO:0000256|ARBA:ARBA00048081}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L- CC lysyl-[histone] + S-adenosyl-L-homocysteine + H(+); CC Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; Evidence={ECO:0000256|PROSITE- CC ProRule:PRU00900}; CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase CC superfamily. Histone-lysine methyltransferase family. Suvar4-20 CC subfamily. {ECO:0000256|PROSITE-ProRule:PRU00900}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EFE39408.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ACYE01000337; EFE39408.1; -; Genomic_DNA. DR RefSeq; XP_003020032.1; XM_003019986.1. DR AlphaFoldDB; D4DFE6; -. DR GeneID; 9583814; -. DR KEGG; tve:TRV_05893; -. DR HOGENOM; CLU_013724_0_0_1; -. DR OrthoDB; 4290at34384; -. DR Proteomes; UP000008383; Unassembled WGS sequence. DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0140943; F:histone H4K20 trimethyltransferase activity; IEA:UniProtKB-EC. DR CDD; cd10524; SET_Suv4-20-like; 1. DR Gene3D; 1.10.10.1700; Histone-lysine N-methyltransferase; 1. DR Gene3D; 2.170.270.10; SET domain; 1. DR InterPro; IPR041938; Hist-Lys_N-MTase_N. DR InterPro; IPR025783; Set9_fungi. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR InterPro; IPR039977; Suv4-20/Set9. DR PANTHER; PTHR12977:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B; 1. DR PANTHER; PTHR12977; SUPPRESSOR OF VARIEGATION 4-20-RELATED; 1. DR Pfam; PF00856; SET; 1. DR SMART; SM00317; SET; 1. DR SUPFAM; SSF82199; SET domain; 1. DR PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1. DR PROSITE; PS50280; SET; 1. PE 3: Inferred from homology; KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853}; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE- KW ProRule:PRU00900}; Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000008383}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, KW ECO:0000256|PROSITE-ProRule:PRU00900}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE- KW ProRule:PRU00900}. FT DOMAIN 115..229 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT REGION 269..369 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 381..480 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 331..343 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 354..368 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 394..406 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 228 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00190" SQ SEQUENCE 535 AA; 59083 MW; 8E5D734088E35605 CRC64; MPRTPTVEKR ERLTLSQLAT YDDILTDTLV DHAFFWTTIR KNRTKYFPVR GINEDTITSI LLHDVIVAKD VPKAEKQLLA LPGLKKFTDR LLSDREREWF RRHLRKYISI YLPDCPFEVT TTNRYTVLTH EAAVSARKFI PSGHPVKYLS GTLVSITKEE ENDLDLTKRD FSIVMSTRKK TASLFLGPAR FANHDCNANA KLVTRGFESM EVVATQDIDI GDEITVSYGD NYFSEDNCEC LCHSCEMAQR NGWSSPSASR VNSWVHSSSE FADASEHPPS SSNGCEKHEL ETDSESSDGF LGKRRKVERK SSNLRLQESV DDTVGVDAKP NQGSPSPVTN TCSPLAGNAE ESNDSTLPGG NSTKNKCSTA DIPLCDEEVS AACRASRDTS IENSSGQSSG STAATSCPGS GDQAPLAPET EDSTTNEPGK IEKIPELQLK PPFPQIILGD SETDLSDLST VSEPVESEAT NDAPRPKRKY KKRGLPLPVV EEPPIFKEKL ILQEKNVHVV NGILNYMDID GPKLIRRVGV TKKNG //