ID   D3ZTY5_RAT              Unreviewed;       461 AA.
AC   D3ZTY5;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   04-NOV-2026, entry version 113.
DE   SubName: Full=USH1 protein network component sans {ECO:0000313|Ensembl:ENSRNOP00000032135.2};
GN   Name=Ush1g {ECO:0000313|Ensembl:ENSRNOP00000032135.2,
GN   ECO:0000313|RGD:1304551};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000032135.2, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000032135.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000032135.2};
RA   Doris P.A., Kalbfleisch T., Li K., Howe K., Wood J.;
RT   "GRCr8: a new rat reference genome assembly contstructed from accurate long
RT   reads and long range scaffolding.";
RL   Submitted (JAN-2024) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000032135.2}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000032135.2};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
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DR   RefSeq; NP_001099320.1; NM_001105850.2.
DR   AlphaFoldDB; D3ZTY5; -.
DR   SMR; D3ZTY5; -.
DR   FunCoup; D3ZTY5; 85.
DR   STRING; 10116.ENSRNOP00000032135; -.
DR   PaxDb; 10116-ENSRNOP00000032135; -.
DR   Ensembl; ENSRNOT00000039387.4; ENSRNOP00000032135.2; ENSRNOG00000028456.4.
DR   GeneID; 287819; -.
DR   KEGG; rno:287819; -.
DR   AGR; RGD:1304551; -.
DR   CTD; 124590; -.
DR   RGD; 1304551; Ush1g.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00390000017548; -.
DR   HOGENOM; CLU_028071_0_0_1; -.
DR   OMA; AAKVWCT; -.
DR   OrthoDB; 76949at2759; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000028456; Expressed in cerebellum and 4 other cell types or tissues.
DR   ExpressionAtlas; D3ZTY5; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; ISO:RGD.
DR   GO; GO:0015030; C:Cajal body; ISO:RGD.
DR   GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR   GO; GO:0097546; C:ciliary base; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0016607; C:nuclear speck; ISO:RGD.
DR   GO; GO:0097733; C:photoreceptor cell cilium; ISO:RGD.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; ISO:RGD.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0030507; F:spectrin binding; ISO:RGD.
DR   GO; GO:0050957; P:equilibrioception; ISO:RGD.
DR   GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR   GO; GO:0060113; P:inner ear receptor cell differentiation; ISO:RGD.
DR   GO; GO:0060122; P:inner ear receptor cell stereocilium organization; ISO:RGD.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISO:RGD.
DR   GO; GO:2000369; P:regulation of clathrin-dependent endocytosis; ISO:RGD.
DR   GO; GO:0050953; P:sensory perception of light stimulus; ISO:RGD.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   CDD; cd21803; CEN_USH1G; 1.
DR   CDD; cd09586; SAM_USH1G; 1.
DR   FunFam; 1.10.150.50:FF:000034; ankyrin repeat and SAM domain-containing protein 4B; 1.
DR   FunFam; 1.25.40.20:FF:000074; Usher syndrome type-1G protein isoform X1; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR064702; CEN_USH1G.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037602; USH1G_SAM.
DR   PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR24161:SF24; PRE-MRNA SPLICING REGULATOR USH1G; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          329..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  51559 MW;  38A6F4533071FE71 CRC64;
     MNDQYHRAAR DGYLELLKEA TRKELNAPDE DGMTPTLWAA YHGNLESLRL IVSRGGDPDK
     CDIWGNTPLH LAASNGHLHC LSFLVSFGAN IWCLDNDYHT PLDMAAMKGH MECVRYLDSI
     AAKQSSLNPK LVGKLKDKAF REAERRIREC AKMQRKHHER MERRYRRELA ERSDTLSFSS
     LTSSTLSRRL QHMTLGSQLP YSQATLHGTA KGKAKIQKKL ERRKQGVEGT FKVSEDGRKS
     VRSLSGLQLG NDVMFVRQGT YANPKEWGRA PLRDMFLSDE DSVSRATLAA EPAHSEVSTD
     SGHDSLFTRP GLGTMVFRRN YVSSGLHGLG REDGGLDGAG TPRGRLHSSP SLDDDSLGSA
     NSLQDRSCGE ELPWDELDLG LDEDLEPETS PLETFLASLH MEDFASLLRH EKIDLEALML
     CSDLDLRSIS VPLGPRKKIL GAVRRRRQAL ERPLALEDTE L
//