ID   D3ZDW5_RAT              Unreviewed;       235 AA.
AC   D3ZDW5;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   08-OCT-2025, sequence version 4.
DT   10-JUN-2026, entry version 91.
DE   RecName: Full=Uroplakin-1a {ECO:0000256|ARBA:ARBA00069071};
DE   AltName: Full=Uroplakin Ia {ECO:0000256|ARBA:ARBA00083050};
GN   Name=Upk1a {ECO:0000313|Ensembl:ENSRNOP00000036268.6,
GN   ECO:0000313|RGD:1309849};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000036268.6, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000036268.6}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000036268.6};
RA   Doris P.A., Kalbfleisch T., Li K., Howe K., Wood J.;
RT   "GRCr8: a new rat reference genome assembly contstructed from accurate long
RT   reads and long range scaffolding.";
RL   Submitted (JAN-2024) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000036268.6}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000036268.6};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC       specialized biomembrane elaborated by terminally differentiated
CC       urothelial cells. May play an important role in normal bladder
CC       epithelial physiology, possibly in regulating membrane permeability of
CC       superficial umbrella cells or in stabilizing the apical membrane
CC       through AUM/cytoskeletal interactions. {ECO:0000256|ARBA:ARBA00049584}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|ARBA:ARBA00006840}.
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DR   AlphaFoldDB; D3ZDW5; -.
DR   STRING; 10116.ENSRNOP00000036268; -.
DR   PaxDb; 10116-ENSRNOP00000036268; -.
DR   Ensembl; ENSRNOT00000033621.6; ENSRNOP00000036268.6; ENSRNOG00000024331.6.
DR   AGR; RGD:1309849; -.
DR   RGD; 1309849; Upk1a.
DR   VEuPathDB; HostDB:ENSRNOG00000024331; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000160881; -.
DR   HOGENOM; CLU_088971_1_0_1; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000024331; Expressed in testis and 11 other cell types or tissues.
DR   ExpressionAtlas; D3ZDW5; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd03156; uroplakin_I_like_LEL; 1.
DR   FunFam; 1.10.1450.10:FF:000017; Tetraspanin; 1.
DR   Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR47110; TESTIS-SPECIFIC EXPRESSED PROTEIN 55; 1.
DR   PANTHER; PTHR47110:SF2; UROPLAKIN-1B; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        70..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   235 AA;  26820 MW;  EE776127F21CF466 CRC64;
     MLGLKLSGLA LFAETVWVTA DQYRVYPLMG VSGKDDVFAG AWIAIFCGFS FFVVASFGVG
     AALCRRRYMI LTYLLLMLIV YIFECASCIT SYTHRDYMVS NPSLITKQML TFYSADTDQG
     QELTRLWDRI MIEQECCGTS GPMDWVNYTS AFRAATPEVV FPWPPLCCRR TGNFIPINED
     GCRVGHMDYL FTKGCFEHIS HAIDSYTWGI SWFGFAILMW TLPVMMIAMY FYTIL
//