ID D3Z314_MOUSE Unreviewed; 170 AA. AC D3Z314; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 02-SEP-2026, entry version 101. DE SubName: Full=Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 {ECO:0000313|Ensembl:ENSMUSP00000119056.2}; DE Flags: Fragment; GN Name=Slc11a2 {ECO:0000313|Ensembl:ENSMUSP00000119056.2, GN ECO:0000313|MGI:MGI:1345279}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119056.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000119056.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119056.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000119056.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119056.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000119056.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119056.2}; RG Ensembl; RL Submitted (JAN-2026) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Late endosome membrane CC {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004155}. CC -!- SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family. CC {ECO:0000256|ARBA:ARBA00009965}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; D3Z314; -. DR SMR; D3Z314; -. DR SwissPalm; D3Z314; -. DR jPOST; D3Z314; -. DR PeptideAtlas; D3Z314; -. DR ProteomicsDB; 306142; -. DR Antibodypedia; 26282; 376 antibodies from 34 providers. DR Ensembl; ENSMUST00000123461.8; ENSMUSP00000119056.2; ENSMUSG00000023030.17. DR AGR; MGI:1345279; -. DR MGI; MGI:1345279; Slc11a2. DR VEuPathDB; HostDB:ENSMUSG00000023030; -. DR GeneTree; ENSGT00940000155330; -. DR HOGENOM; CLU_1574315_0_0_1; -. DR OMA; PWMQFYQ; -. DR Proteomes; UP000000589; Chromosome 15. DR Bgee; ENSMUSG00000023030; Expressed in epithelium of small intestine and 246 other cell types or tissues. DR ExpressionAtlas; D3Z314; baseline and differential. DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-ARBA. DR InterPro; IPR001046; NRAMP_fam. DR NCBIfam; NF037982; Nramp_1; 1. DR PANTHER; PTHR11706:SF40; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2; 1. DR PANTHER; PTHR11706; SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER; 1. DR Pfam; PF01566; Nramp; 1. PE 1: Evidence at protein level; KW Ion transport {ECO:0000256|ARBA:ARBA00022496}; KW Iron {ECO:0000256|ARBA:ARBA00022496}; KW Iron transport {ECO:0000256|ARBA:ARBA00022496}; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|PeptideAtlas:D3Z314, KW ECO:0007829|ProteomicsDB:D3Z314}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022496}. FT TRANSMEM 97..118 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 1..45 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..20 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 30..40 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 170 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000119056.2" SQ SEQUENCE 170 AA; 18480 MW; 94F283415217A7DD CRC64; MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI //