ID D3P9B3_DEFDS Unreviewed; 608 AA. AC D3P9B3; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 02-SEP-2026, entry version 81. DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203}; DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203}; DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203}; GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203, GN ECO:0000313|EMBL:BAI81303.1}; GN OrderedLocusNames=DEFDS_1848 {ECO:0000313|EMBL:BAI81303.1}; OS Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / OS SSM1). OC Bacteria; Pseudomonadati; Deferribacterota; Deferribacteres; OC Deferribacterales; Deferribacteraceae; Deferribacter. OX NCBI_TaxID=639282 {ECO:0000313|EMBL:BAI81303.1, ECO:0000313|Proteomes:UP000001520}; RN [1] {ECO:0000313|EMBL:BAI81303.1, ECO:0000313|Proteomes:UP000001520} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 14783 / JCM 11476 / NBRC 101012 / SSM1 RC {ECO:0000313|Proteomes:UP000001520}; RX PubMed=20189949; DOI=10.1093/dnares/dsq005; RA Takaki Y., Shimamura S., Nakagawa S., Fukuhara Y., Horikawa H., Ankai A., RA Harada T., Hosoyama A., Oguchi A., Fukui S., Fujita N., Takami H., RA Takai K.; RT "Bacterial lifestyle in a deep-sea hydrothermal vent chimney revealed by RT the genome sequence of the thermophilic bacterium Deferribacter RT desulfuricans SSM1."; RL DNA Res. 17:123-137(2010). CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the CC lesion. The N-terminal half is responsible for the 3' incision and the CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP- CC Rule:MF_00203}. CC -!- SUBUNIT: Interacts with UvrB in an incision complex. CC {ECO:0000256|HAMAP-Rule:MF_00203}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}. CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP- CC Rule:MF_00203}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP011529; BAI81303.1; -; Genomic_DNA. DR AlphaFoldDB; D3P9B3; -. DR STRING; 639282.DEFDS_1848; -. DR KEGG; ddf:DEFDS_1848; -. DR eggNOG; COG0322; Bacteria. DR HOGENOM; CLU_014841_3_1_0; -. DR Proteomes; UP000001520; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule. DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule. DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule. DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1. DR FunFam; 3.40.1440.10:FF:000001; UvrABC system protein C; 1. DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1. DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1. DR Gene3D; 4.10.860.10; UVR domain; 1. DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1. DR HAMAP; MF_00203; UvrC; 1. DR InterPro; IPR000305; GIY-YIG_endonuc. DR InterPro; IPR035901; GIY-YIG_endonuc_sf. DR InterPro; IPR047296; GIY-YIG_UvrC_Cho. DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif. DR InterPro; IPR010994; RuvA_2-like. DR InterPro; IPR001943; UVR_dom. DR InterPro; IPR036876; UVR_dom_sf. DR InterPro; IPR050066; UvrABC_protein_C. DR InterPro; IPR004791; UvrC. DR InterPro; IPR060385; UvrC_M. DR InterPro; IPR001162; UvrC_RNase_H_dom. DR InterPro; IPR038476; UvrC_RNase_H_dom_sf. DR NCBIfam; TIGR00194; uvrC; 1. DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1. DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1. DR Pfam; PF30054; GIY-YIG_UvrC; 1. DR Pfam; PF02151; UVR; 1. DR Pfam; PF27096; UvrC_M; 1. DR Pfam; PF22920; UvrC_RNaseH; 1. DR Pfam; PF08459; UvrC_RNaseH_dom; 1. DR SMART; SM00465; GIYc; 1. DR SMART; SM00278; HhH1; 2. DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1. DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1. DR SUPFAM; SSF47781; RuvA domain 2-like; 1. DR PROSITE; PS50164; GIY_YIG; 1. DR PROSITE; PS50151; UVR; 1. DR PROSITE; PS50165; UVRC; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP- KW Rule:MF_00203}; KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP- KW Rule:MF_00203}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP- KW Rule:MF_00203}; KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP- KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000001520}; KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP- KW Rule:MF_00203}. FT DOMAIN 17..94 FT /note="GIY-YIG" FT /evidence="ECO:0000259|PROSITE:PS50164" FT DOMAIN 201..236 FT /note="UVR" FT /evidence="ECO:0000259|PROSITE:PS50151" FT DOMAIN 267..471 FT /note="UvrC family homology region profile" FT /evidence="ECO:0000259|PROSITE:PS50165" SQ SEQUENCE 608 AA; 70918 MW; 2EE7FA55E2811123 CRC64; MLDFFNMKKF DFNTIPEKPG VYIFLDKNST PLYIGKAKNL RNRVKSYFTN NLNLKTEIMV QKAFDIKYII TKNEVEALLL EANLIKKEKP KYNILLKDSK SYPYLEITAH EYPKIKISRK ISSDSTYLGP FVNVSDLREI LRELLKLFPI RTCSEQTFKK GKSCINYQIK RCTAPCEGLI SKEEYMSLVD NIISVFKGKT KNLLEYFEEK MILHSKKLEF EKAAEYRDKI NGLKKLSLNQ HIVYKTDANI DILYFKTIYE QYSGLLIIFI RNGKIIGVDR EIFNSQIYQD DIPGFIIQFY TKNKILPEKI SIIINNNYFT DRLLEDTLKE FKKNIKLTKS IKKDILDFAD KNLQIFFETE LSKKIKSKDL FEHLAKKCHL PNDINTIECI DISHLYGKNT VGVSIFFENG SFNKNRYRRY KIKSANNDDF LAIHEIFRRK ALNIMKNKEE QADLYIIDGG KGQLQSAIRA FKEQNIQANF ISIAKGRSKD EPNNNLSKEE VYIPGRKNPI NFKKDDPVLL LIQKLRDEAH RFAIEYQRKL ALKDLTSSPL LQIKGVGEKT IKKVLKEFPD IYTNSNITSE ELSKKCKISK KVAEDIVNFL RTFQGNSS //