ID   D2X2F9_DANRE            Unreviewed;       867 AA.
AC   D2X2F9; A0A8M9QCV7;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   02-SEP-2026, entry version 91.
DE   SubName: Full=Neuroligin 1 {ECO:0000313|EMBL:ADB12617.1};
GN   Name=nlgn1 {ECO:0000313|EMBL:ADB12617.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-090918-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:ADB12617.1};
RN   [1] {ECO:0000313|EMBL:ADB12617.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20034102; DOI=10.1002/dvdy.22196;
RA   Rissone A., Sangiorgio L., Monopoli M., Beltrame M., Zucchi I.,
RA   Bussolino F., Arese M., Cotelli F.;
RT   "Characterization of the neuroligin gene family expression and evolution in
RT   zebrafish.";
RL   Dev. Dyn. 239:688-702(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
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DR   EMBL; GQ489190; ADB12617.1; -; mRNA.
DR   RefSeq; XP_017213657.1; XM_017358168.4.
DR   RefSeq; XP_021335199.1; XM_021479524.3.
DR   RefSeq; XP_073771404.1; XM_073915303.1.
DR   AlphaFoldDB; D2X2F9; -.
DR   SMR; D2X2F9; -.
DR   STRING; 7955.ENSDARP00000155186; -.
DR   ESTHER; danre-1neur; Neuroligin.
DR   GlyGen; D2X2F9; 1 site.
DR   PaxDb; 7955-ENSDARP00000155186; -.
DR   PeptideAtlas; D2X2F9; -.
DR   GeneID; 100002610; -.
DR   AGR; ZFIN:ZDB-GENE-090918-1; -.
DR   CTD; 22871; -.
DR   ZFIN; ZDB-GENE-090918-1; nlgn1.
DR   GeneTree; ENSGT00940000155789; -.
DR   OMA; SLHPHDM; -.
DR   OrthoDB; 6846267at2759; -.
DR   Reactome; R-DRE-6794361; Neurexins and neuroligins.
DR   Bgee; ENSDARG00000077710; Expressed in testis and 29 other cell types or tissues.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0099634; C:postsynaptic specialization membrane; IBA:GO_Central.
DR   GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR   GO; GO:0002040; P:sprouting angiogenesis; IGI:ZFIN.
DR   GO; GO:0007416; P:synapse assembly; IEA:UniProtKB-ARBA.
DR   FunFam; 3.40.50.1820:FF:000001; Neuroligin 3 isoform; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase_fold.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR051093; Neuroligin/BSAL.
DR   InterPro; IPR000460; Nlgn.
DR   PANTHER; PTHR43903; NEUROLIGIN; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR01090; NEUROLIGIN.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        721..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          53..647
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   REGION          184..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          668..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          841..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..207
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..706
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..854
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        857..867
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   867 AA;  97540 MW;  6B775016FA8C057C CRC64;
     MPFQQPNRLS SIWKAMCPRL GLSASLDLPF LCWIVGLALH AQLAASEKLD ETDPIVTTTY
     GKVRGFKKEL NNEILGPVIQ FLGVPYAAPP TGERRFQPPE PPISWSEIRN ATQFAPVCPQ
     TLLEGRLPDV MLPVWFTNSI EVVSSYVQDQ SEDCLFLNIY VPTEDVKRIS KECARKPGKK
     ICRKGGPLSK KQNDDLADND GAEDEDIRES GSPKPVMVFV HGGSYMEGTG NMFDGSILAS
     YGNVIVITVN YRLGVLGFLS TGDQAAKGNY GLLDLIQALR WTSENIAFFG GDPLRITVFG
     SGAGASCVNL LTLSHYSEGN RWSNSTKGLF QRAIAQSGTA LSSWAVSFQP AKYARMLAKK
     VGCNLKDTVE MVECLQKKHY KELVEQDIQP ARYHIAFGPV IDGDVIPDDP QILMEQGEFL
     NYDIMLGVNQ GEGLKFVELI VDNENGVQAN DFDYAVSSFV DDLYGYPEGK DILRETIKFM
     YTDWADRHNP ETRRKTLLAL FTDHQWVAPA VATADLHSSF GSPTYFYAFY HHCQTEQVPP
     WADAAHGDEI PYVFGLPMIG PTELFPCNFS KNDVMLSAVV MTYWTNFAKT GDPNQPVPQD
     TKFIHTKPNR FEEVAWTRYN QKDQLYLHIG LKPRVKEHYR ANKVNLWLEL VPHLHSLNEV
     SQIISTTKLP PPEVTPRTPK KIPVNTKRPY PTPFPTETQD SHNQNQNQPF LVDQRDYSTE
     LSVTIAVGAS LLFLNILAFA ALYYKKDKRR HEVHRRCSPQ RTTANELPHT QEEEIMSLQM
     KHSDLERECR EAMHPHEVVL RTACPPDYTL AMRRSPDDIP LMTPNTITMI PNSMPGLTSL
     HPFNSYSSGQ NNTLPHPHPH SHSTTRV
//