ID   D2D3P4_CHICK            Unreviewed;       221 AA.
AC   D2D3P4; A0A1D5P7B6;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   02-SEP-2026, entry version 117.
DE   RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE            EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
GN   Name=Rab27a {ECO:0000313|EMBL:ACT15614.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|EMBL:ACT15614.1};
RN   [1] {ECO:0000313|EMBL:ACT15614.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Vaez M., Burke T.;
RT   "Population genetics and molecular evolution of plumage genes: Rab27a.";
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00047660};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00047660};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004635}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|PROSITE-ProRule:PRU00753}.
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DR   EMBL; FJ449551; ACT15614.1; -; mRNA.
DR   AlphaFoldDB; D2D3P4; -.
DR   SMR; D2D3P4; -.
DR   STRING; 9031.ENSGALP00000066798; -.
DR   PaxDb; 9031-ENSGALP00000066798; -.
DR   VEuPathDB; HostDB:geneid_415410; -.
DR   eggNOG; KOG0081; Eukaryota.
DR   HOGENOM; CLU_041217_10_1_1; -.
DR   InParanoid; D2D3P4; -.
DR   Bgee; ENSGALG00000004435; Expressed in granulocyte and 13 other cell types or tissues.
DR   GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   CDD; cd04127; Rab27A; 1.
DR   FunFam; 3.40.50.300:FF:000402; Ras-related protein Rab-27A; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041837; Rab27a/b.
DR   InterPro; IPR005225; Small_GTP-bd.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR050305; Small_GTPase_Rab.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR47980; LD44762P; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PROSITE-
KW   ProRule:PRU00753}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00753}; Prenylation {ECO:0000256|ARBA:ARBA00023289}.
FT   REGION          36..44
FT                   /note="Switch-I"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00753"
FT   REGION          77..93
FT                   /note="Switch-II"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00753"
SQ   SEQUENCE   221 AA;  25066 MW;  CEED02401D349B04 CRC64;
     MSDGDYDYLI KFLALGDSGV GKTSLLYQYT DGKFNSKFIT TVGIDFREKR VVYRPNGPDG
     VGGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH
     AYCENPDIVL CGNKSDLEDQ RMVKEEEAKE LAEKYGIPYF ETSAANGNNV SKAIDTLLDL
     IMKRMERCVD KSWIPEGVVR SNGHSSTEQL SEEQEKGKCG C
//