ID   D2ATG9_STRRD            Unreviewed;      1835 AA.
AC   D2ATG9;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   02-SEP-2026, entry version 101.
DE   RecName: Full=Phenyloxazoline synthase MbtB {ECO:0000256|ARBA:ARBA00016743};
DE   AltName: Full=Mycobactin synthetase protein B {ECO:0000256|ARBA:ARBA00033440};
GN   OrderedLocusNames=Sros_3767 {ECO:0000313|EMBL:ACZ86689.1};
OS   Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 /
OS   KCTC 9067 / NCIMB 10171 / NRRL 2505 / NI 9100).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Streptosporangium.
OX   NCBI_TaxID=479432 {ECO:0000313|EMBL:ACZ86689.1, ECO:0000313|Proteomes:UP000002029};
RN   [1] {ECO:0000313|EMBL:ACZ86689.1, ECO:0000313|Proteomes:UP000002029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100
RC   {ECO:0000313|Proteomes:UP000002029};
RX   PubMed=21304675; DOI=10.4056/sigs.631049;
RA   Nolan M., Sikorski J., Jando M., Lucas S., Lapidus A., Glavina Del Rio T.,
RA   Chen F., Tice H., Pitluck S., Cheng J.F., Chertkov O., Sims D., Meincke L.,
RA   Brettin T., Han C., Detter J.C., Bruce D., Goodwin L., Land M., Hauser L.,
RA   Chang Y.J., Jeffries C.D., Ivanova N., Mavromatis K., Mikhailova N.,
RA   Chen A., Palaniappan K., Chain P., Rohde M., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Streptosporangium roseum type strain (NI
RT   9100).";
RL   Stand. Genomic Sci. 2:29-37(2010).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957, ECO:0000256|PROSITE-
CC         ProRule:PRU00258};
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005102}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       MbtB subfamily. {ECO:0000256|ARBA:ARBA00007380}.
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DR   EMBL; CP001814; ACZ86689.1; -; Genomic_DNA.
DR   STRING; 479432.Sros_3767; -.
DR   KEGG; sro:Sros_3767; -.
DR   eggNOG; COG1020; Bacteria.
DR   eggNOG; COG2226; Bacteria.
DR   eggNOG; COG3319; Bacteria.
DR   HOGENOM; CLU_000022_2_15_11; -.
DR   Proteomes; UP000002029; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:TreeGrafter.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043041; P:amino acid activation for nonribosomal peptide biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProtKB-ARBA.
DR   CDD; cd12114; A_NRPS_TlmIV_like; 1.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd19535; Cyc_NRPS; 1.
DR   FunFam; 1.10.1200.10:FF:000016; Non-ribosomal peptide synthase; 1.
DR   FunFam; 3.30.559.10:FF:000023; Non-ribosomal peptide synthetase; 1.
DR   FunFam; 3.40.50.12780:FF:000012; Non-ribosomal peptide synthetase; 1.
DR   FunFam; 3.30.559.30:FF:000006; Yersiniabactin polyketide/non-ribosomal peptide synthetase; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 1.10.10.1830; Non-ribosomal peptide synthase, adenylation domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR010071; AA_adenyl_dom.
DR   InterPro; IPR029058; AB_hydrolase_fold.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-b_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_synth/lig_dom.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensation_dom.
DR   InterPro; IPR057737; Condensation_MtbB-like.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR041464; TubC_N.
DR   InterPro; IPR044894; TubC_N_sf.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   PANTHER; PTHR45527:SF10; PYOCHELIN SYNTHASE PCHF; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   Pfam; PF18563; TubC_N; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450, ECO:0000256|PROSITE-
KW   ProRule:PRU00258}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002029};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1431..1512
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1508..1533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1508..1519
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1466
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   1835 AA;  200928 MW;  F70BCDABB5ABDB7D CRC64;
     MTAGAGKPGG GERAAAGRLV AELERQGVRL WEEDGRLRFR APQGVLTDER RALLSAHKEA
     VLDHLSRPGP EVTPQPEDRH EPFPLTDVQA AYVLGRRDAF DYGGTACQVY AELAFPELDP
     PRLEAAWRAL VRRHDMLRAV VHVDGYQQVL ADVPDYRIEV TDLRGEPAGR VSGHLDEVRA
     AMDHRVYDAD AWPLFELRVT RTDGQALLHV SIDFLIADYL SIQLLLTELK RLYLDPDHPL
     PPLEIGFRDY LLAARRLREG AAYERDRDYW EGRVDELPGP PELPVRDNAA AEAGRRFTRH
     QVTLDAGQWE RFRARSGAHG VTPSTAVLAA FAEVVARWSR RPRFSLNLTL LNRQPLHPQV
     GGLVGDFTTV SLLAVDGEAG AAFHGRARAL QDRLWEDLDH RLYSGVEVMR EIARRRGRGA
     ALMPVVFTST IGLSDEASGH EGMNGLAEVV YGRSQTPQVW IDCQAVVEGG ALEVRWDVRD
     GVFPPGLVED AFGAMEELLR ALATSDEPWD SACPVALPAV QAGRRDRVNA TTEPLPRGLL
     HEAVVAQALR EPGRAAVVTG ERTLTYGELL ARAVGVAETL KARGFEQGAL AAVMMDKGWE
     QVVAVLGTLL AGGAYLPVDT GQPPARRARI LADAGVRHVL TQSWIRDRPE GADLVDVDLL
     LPSALPAPQP AADPGDLAYV IYTSGSTGDP KGVMISHRAA LNTVADVNRR FAVTAEDRVL
     GLAGLGFDLS VYDIFGPLSL GGALVLPDAE GRGDPAHWAR LIAGHGVTVW NSVPAQLQML
     DHYLGSQPEP DLPSLRLAML SGDWIPIALP GRVRGRLPGL ELISLGGATE AAIWSIYHPI
     GEVRDGLRSI PYGTPLANQA FHVLDEALRP CPDWVPGELY ISGAGLALGY LGDEDRTAQR
     FIRRPGTGER LYRTGDLGRY HDDGTIEFLG REDRQVKIRG HRIELAEVEA AIQSHPAVAA
     VHVLLDGTGM ERRLAAFAEP VRRAASGDDP AAELAAAAAA AADPHTTHID RAELMEFIGR
     LDRAAVIGMM WALRRRGLFG STSERTTTEQ VLAATGAAPR HHRLVRRWLR VLEREGVIAG
     DGDGFRATRV IEAADLARAW QAVEELQRED SYKAVLIDYF KESTERLPEL LRDELDPLPL
     LFPEGRLEIS EAAYRENIIS RYVNHAAIAV LRGIAARHDG PLRVIEVGAG VGGTSAQMIP
     ALAEFDVDYL FTDVSPFFLN EARERFGERP WVRYGLFDIN EDYREQGYAP NDFDVVLCAN
     VLHNSRHAGR VLAGLREMLR PGGWLVFIET TKDSYQIMTS MEFMMPEKDP RKWDYEDLRK
     GRDQTFLGRE EWLGLLTGAG ADTTLCLPGP DDVTGPLGQN VFAARFKSDR ARLGVAGLAE
     HLADRLPEYM IPSHTQVVDA LPLTGNGKVD HAALRSWLPR AASGRAAAGG EPRDDLERRL
     AAVWAEVLGL VRVDREEDFF ELGGDSLVVA KLAARLREEV AETRDLFWDD LVRQILHRPT
     VAALAEHVRR ARDEEESGPR GEASPLVPLG GDEDGGDGAL RVLVHEGSGT LAPYRALARL
     LAAKGGPLVG LAITEVERYL AEEPEGLIER RAARYARALL DTGSSRFHVV GYCMGGLLAT
     EVARHLTEAG AAVESLTVIS SYTLPRIIED ELVVEYVFAR VMGIDPADAG YPGDEATMSR
     VFELLLAEDP ERVPAGRVAG LTGDPALESA AADFRRLAGL SQRERLAAIG RAATETRSDP
     EVERHVNSLF QVVRHSLLAV GTHTPEPYAG DITFLRQLGD TRFLPWLRDD MTGFWRELCL
     GDLEVVDVPG DHFTCLQPPN VDEVATFLAT SQAAR
//