ID   D0MY04_PHYIT            Unreviewed;       491 AA.
AC   D0MY04;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   02-SEP-2026, entry version 68.
DE   SubName: Full=Alanine aminotransferase 2 {ECO:0000313|EMBL:EEY66052.1};
GN   ORFNames=PITG_03593 {ECO:0000313|EMBL:EEY66052.1};
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporomycetes;
OC   Peronosporales; Peronosporaceae; Phytophthora.
OX   NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY66052.1, ECO:0000313|Proteomes:UP000006643};
RN   [1] {ECO:0000313|Proteomes:UP000006643}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. Alanine aminotransferase subfamily.
CC       {ECO:0000256|ARBA:ARBA00025785}.
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DR   EMBL; DS028121; EEY66052.1; -; Genomic_DNA.
DR   RefSeq; XP_002906651.1; XM_002906605.1.
DR   AlphaFoldDB; D0MY04; -.
DR   STRING; 403677.D0MY04; -.
DR   GeneID; 9467546; -.
DR   KEGG; pif:PITG_03593; -.
DR   VEuPathDB; FungiDB:PITG_03593; -.
DR   eggNOG; KOG0258; Eukaryota.
DR   HOGENOM; CLU_014254_3_0_1; -.
DR   InParanoid; D0MY04; -.
DR   OMA; GTQHFRV; -.
DR   OrthoDB; 1732682at2759; -.
DR   UniPathway; UPA00528; UER00586.
DR   Proteomes; UP000006643; Unassembled WGS sequence.
DR   GO; GO:0004021; F:L-alanine:2-oxoglutarate transaminase activity; IEA:TreeGrafter.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00609; AAT_like; 1.
DR   FunFam; 1.10.287.1970:FF:000001; Alanine aminotransferase 2; 1.
DR   FunFam; 3.40.640.10:FF:000012; alanine aminotransferase 2; 1.
DR   FunFam; 3.90.1150.10:FF:000151; Alanine aminotransferase 2; 1.
DR   Gene3D; 1.10.287.1970; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR045088; ALAT1/2-like.
DR   InterPro; IPR004839; Aminotransferase_I/II_large.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11751; ALANINE AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR11751:SF29; ALANINE TRANSAMINASE; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000256|ARBA:ARBA00022576,
KW   ECO:0000313|EMBL:EEY66052.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          106..470
FT                   /note="Aminotransferase class I/classII large"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   491 AA;  54105 MW;  5DCCA63C061FB0D9 CRC64;
     MPDNGAKVLT RGTFNPNVVK AEYAVRGALV LRSNEYENRL ANGDKSLPFD KVIPCNIGNP
     QVLKQEPIEF HRQVLALVNV PGLVDQPEAQ KLFPPDAIAR AKFYMDNIVG GTGAYGHSKG
     SAVVRQEVAR FLKRRDGHPA DPEDIYLTDG ASPAVQNSLL ALIRDENDAI LAPIPQYPLY
     SAAIAINGGT LVGYYLDEAK AWGLDVDELT RAVKEARDAG KTVRAMAVIN PGNPTGQCLS
     ADAMKEIIKF CQKENILILA DEVYQENVYA EDKKFFSFKK VLRDMGKEYD DVELISFHST
     SKGFTGECGR RGGYMELVNI DEGAKDQFYK LMSVNLCSNI EGQLMVGMMT NPPQPGDASY
     QRYAEQRDRT LRSLKHRAKK LVKAFNGLEG VKCNETEGAL YTFPSVTIPA KAVEAAKVAG
     MAPDAFYCTQ MLDETGIVVV PGSGFGQRAG TWHFRSTILP PEEAVDEVIE KTAKFHAKFM
     DKYRENVART A
//