ID   CLD25_HUMAN             Reviewed;         229 AA.
AC   C9JDP6;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   02-SEP-2026, entry version 93.
DE   RecName: Full=Claudin-25;
GN   Name=CLDN25;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30734065; DOI=10.1007/s00018-019-03030-7;
RA   Berndt P., Winkler L., Cording J., Breitkreuz-Korff O., Rex A., Dithmer S.,
RA   Rausch V., Blasig R., Richter M., Sporbert A., Wolburg H., Blasig I.E.,
RA   Haseloff R.F.;
RT   "Tight junction proteins at the blood-brain barrier: far more than claudin-
RT   5.";
RL   Cell. Mol. Life Sci. 76:1987-2002(2019).
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000269|PubMed:30734065}. Cell membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; AP003170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67230.1; -; Genomic_DNA.
DR   CCDS; CCDS44736.1; -.
DR   RefSeq; NP_001094859.1; NM_001101389.1.
DR   AlphaFoldDB; C9JDP6; -.
DR   SMR; C9JDP6; -.
DR   FunCoup; C9JDP6; 358.
DR   STRING; 9606.ENSP00000396304; -.
DR   GlyGen; C9JDP6; 1 site.
DR   BioMuta; CLDN25; -.
DR   PaxDb; 9606-ENSP00000396304; -.
DR   PeptideAtlas; C9JDP6; -.
DR   Antibodypedia; 56622; 50 antibodies from 12 providers.
DR   DNASU; 644672; -.
DR   Ensembl; ENST00000453129.3; ENSP00000396304.2; ENSG00000228607.3.
DR   GeneID; 644672; -.
DR   KEGG; hsa:644672; -.
DR   MANE-Select; ENST00000453129.3; ENSP00000396304.2; NM_001101389.1; NP_001094859.1.
DR   UCSC; uc009yyw.2; human.
DR   AGR; HGNC:37218; -.
DR   ClinPGx; PA165543379; -.
DR   CTD; 644672; -.
DR   DisGeNET; 644672; -.
DR   GeneCards; CLDN25; -.
DR   HGNC; HGNC:37218; CLDN25.
DR   HPA; ENSG00000228607; Not detected.
DR   MIM; 620812; gene.
DR   OpenTargets; ENSG00000228607; -.
DR   VEuPathDB; HostDB:ENSG00000228607; -.
DR   eggNOG; ENOG502SNF0; Eukaryota.
DR   GeneTree; ENSGT00940000163940; -.
DR   HOGENOM; CLU_076370_1_2_1; -.
DR   InParanoid; C9JDP6; -.
DR   OMA; TVQDFWD; -.
DR   OrthoDB; 8612291at2759; -.
DR   PAN-GO; C9JDP6; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; C9JDP6; -.
DR   PathwayCommons; C9JDP6; -.
DR   Agora; ENSG00000228607; -.
DR   BioGRID-ORCS; 644672; 9 hits in 1138 CRISPR screens.
DR   GenomeRNAi; 644672; -.
DR   Pharos; C9JDP6; Tdark.
DR   PRO; PR:C9JDP6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; C9JDP6; protein.
DR   Bgee; ENSG00000228607; Expressed in olfactory segment of nasal mucosa and 4 other cell types or tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0070160; C:tight junction; IDA:ARUK-UCL.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..229
FT                   /note="Claudin-25"
FT                   /id="PRO_0000395403"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VARIANT         219
FT                   /note="H -> Y (in dbSNP:rs35111413)"
FT                   /id="VAR_063401"
SQ   SEQUENCE   229 AA;  25394 MW;  86EC6AEE87BCA151 CRC64;
     MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI WEVCVDREEV
     ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF GSECFQFHRI RWVFKRRLGL
     LGRTLEASAS ATTLLPVSWV AHATIQDFWD DSIPDIIPRW EFGGALYLGW AAGIFLALGG
     LLLIFSACLG KEDVPFPLMA GPTVPLSCAP VEESDGSFHL MLRPRNLVI
//