ID   C7R2C2_JONDD            Unreviewed;       360 AA.
AC   C7R2C2;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   02-SEP-2026, entry version 83.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
GN   OrderedLocusNames=Jden_0831 {ECO:0000313|EMBL:ACV08493.1};
OS   Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / BCRC 15368 / CIP
OS   55.134 / JCM 11481 / NBRC 15587 / NCTC 10816 / Prevot 55134) (Listeria
OS   denitrificans).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC   Jonesiaceae; Jonesia.
OX   NCBI_TaxID=471856 {ECO:0000313|EMBL:ACV08493.1, ECO:0000313|Proteomes:UP000000628};
RN   [1] {ECO:0000313|EMBL:ACV08493.1, ECO:0000313|Proteomes:UP000000628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14870 / DSM 20603 / BCRC 15368 / CIP 55.134 / JCM 11481 /
RC   NBRC 15587 / NCTC 10816 / Prevot 55134
RC   {ECO:0000313|Proteomes:UP000000628};
RX   PubMed=21304666; DOI=10.4056/sigs.41646;
RA   Pukall R., Gehrich-Schroter G., Lapidus A., Nolan M., Glavina Del Rio T.,
RA   Lucas S., Chen F., Tice H., Pitluck S., Cheng J.F., Copeland A.,
RA   Saunders E., Brettin T., Detter J.C., Bruce D., Goodwin L., Pati A.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Han C.;
RT   "Complete genome sequence of Jonesia denitrificans type strain (Prevot
RT   55134).";
RL   Stand. Genomic Sci. 1:262-269(2009).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; CP001706; ACV08493.1; -; Genomic_DNA.
DR   RefSeq; WP_015771121.1; NC_013174.1.
DR   AlphaFoldDB; C7R2C2; -.
DR   STRING; 471856.Jden_0831; -.
DR   KEGG; jde:Jden_0831; -.
DR   eggNOG; COG1816; Bacteria.
DR   HOGENOM; CLU_039228_0_0_11; -.
DR   OrthoDB; 9779574at2; -.
DR   Proteomes; UP000000628; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-ARBA.
DR   GO; GO:0006154; P:adenosine catabolic process; IEA:TreeGrafter.
DR   GO; GO:0043103; P:hypoxanthine salvage; IEA:TreeGrafter.
DR   GO; GO:0046103; P:inosine biosynthetic process; IEA:TreeGrafter.
DR   FunFam; 3.20.20.140:FF:000020; Adenosine deaminase; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   NCBIfam; NF006847; PRK09358.1-2; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ACV08493.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide metabolism {ECO:0000256|ARBA:ARBA00023080};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000628};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          11..349
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   360 AA;  39153 MW;  7BF0DA0A455CC854 CRC64;
     MTWLDELPSL PKVVLHDHLD GGLRPATIIE LAAQVGHTLP TTDEKELQQW FVDAANSGSL
     ERYLETFDHT IAVMQTADAL TRVAREAVLD LAADGVIYAE SRWAPEQHLA GGLSLDDAVR
     AVQRGLEQGM EEARAGGHDI EVGQLITAMR HADRWEEVAD LALRHRDQGA YGFDIAGAEA
     GFMPDRFPQV WSTLNDAHFP VTIHAGEAAG AESIAQAVGM GHALRVGHGV RIIDDIEGFG
     TDSPRLGRLA HWVRDNQIAL EMCPCSNLQT GAAQSVATHP ITGLRDLDFA VTVNTDNRLM
     SGTSMSHEMR LLATEAGWDV EDFLDATLAA VWSAFIHHDA RHALGERVIA GFDPYVNQGE
//