ID   C7LUP4_DESBD            Unreviewed;       341 AA.
AC   C7LUP4;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   04-NOV-2026, entry version 80.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   OrderedLocusNames=Dbac_2884 {ECO:0000313|EMBL:ACU90959.1};
OS   Desulfomicrobium baculatum (strain DSM 4028 / VKM B-1378 / X)
OS   (Desulfovibrio baculatus).
OC   Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfovibrionia;
OC   Desulfovibrionales; Desulfomicrobiaceae; Desulfomicrobium.
OX   NCBI_TaxID=525897 {ECO:0000313|EMBL:ACU90959.1, ECO:0000313|Proteomes:UP000002216};
RN   [1] {ECO:0000313|EMBL:ACU90959.1, ECO:0000313|Proteomes:UP000002216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 4028 / VKM B-1378 / X {ECO:0000313|Proteomes:UP000002216};
RX   PubMed=21304634; DOI=10.4056/sigs.13134;
RA   Copeland A., Spring S., Goker M., Schneider S., Lapidus A., Del Rio T.G.,
RA   Tice H., Cheng J.F., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA   Ivanova N., Mavrommatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.C., Meincke L.,
RA   Sims D., Brettin T., Detter J.C., Han C., Chain P., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lucas S.;
RT   "Complete genome sequence of Desulfomicrobium baculatum type strain (X).";
RL   Stand. Genomic Sci. 1:29-37(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose
CC         + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377, ChEBI:CHEBI:57477,
CC         ChEBI:CHEBI:57649; EC=4.2.1.46;
CC         Evidence={ECO:0000256|ARBA:ARBA00001539,
CC         ECO:0000256|RuleBase:RU004473};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911,
CC         ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|ARBA:ARBA00008178, ECO:0000256|RuleBase:RU004473}.
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DR   EMBL; CP001629; ACU90959.1; -; Genomic_DNA.
DR   RefSeq; WP_015775048.1; NC_013173.1.
DR   AlphaFoldDB; C7LUP4; -.
DR   STRING; 525897.Dbac_2884; -.
DR   KEGG; dba:Dbac_2884; -.
DR   eggNOG; COG1088; Bacteria.
DR   HOGENOM; CLU_007383_1_14_7; -.
DR   OMA; AACKFEV; -.
DR   OrthoDB; 9803010at2; -.
DR   Proteomes; UP000002216; Chromosome.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   CDD; cd05246; dTDP_GD_SDR_e; 1.
DR   FunFam; 3.40.50.720:FF:000304; UDP-glucose 4,6-dehydratase; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU004473};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002216}.
FT   DOMAIN          4..308
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   341 AA;  38548 MW;  45C7A5C254FEB672 CRC64;
     MHLLVTGGCG FIGSNFIQHM LASHEDVVIV NLDKLTYAGN RRNLAEEEAL HLGRRYHFVH
     GDICDQELVP ELMKRFVFDA VLNFAAESHV DRSISDPFPF VTTNVLGTQN LLEAARRAEI
     PRFVHISTDE VYGTLGPTGQ FTEDTPLAPN SPYSASKASS DLLARAYFHT YGMPVMVTRC
     SNNYGPYQFP EKLIPLVYLK ASRSEPIPVY GDGQNVRDWI YVMDHCRGVE ATLFKGQPGA
     VYNFGGDAER TNLEVVRLIL RLTGKSEDLI THVTDRPGHD RRYAMAFARS TADLGWTPQH
     SFEDGMARTL AWYKANEAWL DEVQSGAYRQ FMDNWYRTRQ A
//