ID   C7LEW1_BRUMC            Unreviewed;       107 AA.
AC   C7LEW1;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   02-SEP-2026, entry version 83.
DE   RecName: Full=Phosphoribosyl-ATP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01020};
DE            Short=PRA-PH {ECO:0000256|HAMAP-Rule:MF_01020};
DE            EC=3.6.1.31 {ECO:0000256|HAMAP-Rule:MF_01020};
GN   Name=hisE {ECO:0000256|HAMAP-Rule:MF_01020,
GN   ECO:0000313|EMBL:ACU49046.1};
GN   OrderedLocusNames=BMI_I2108 {ECO:0000313|EMBL:ACU49046.1};
OS   Brucella microti (strain BCCN 7-01 / CAPM 6434 / CCM 4915).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Brucellaceae; Brucella/Ochrobactrum group; Brucella;
OC   Brucella melitensis group.
OX   NCBI_TaxID=568815 {ECO:0000313|EMBL:ACU49046.1, ECO:0000313|Proteomes:UP000002188};
RN   [1] {ECO:0000313|EMBL:ACU49046.1, ECO:0000313|Proteomes:UP000002188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCM 4915 {ECO:0000313|EMBL:ACU49046.1,
RC   ECO:0000313|Proteomes:UP000002188};
RX   PubMed=19653890; DOI=10.1186/1471-2164-10-352;
RA   Audic S., Lescot M., Claverie J.-M., Scholz H.C.;
RT   "Brucella microti: the genome sequence of an emerging pathogen.";
RL   BMC Genomics 10:352-352(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-
CC         ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00001460, ECO:0000256|HAMAP-
CC         Rule:MF_01020};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
CC       {ECO:0000256|ARBA:ARBA00005204, ECO:0000256|HAMAP-Rule:MF_01020}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_01020}.
CC   -!- SIMILARITY: Belongs to the PRA-PH family.
CC       {ECO:0000256|ARBA:ARBA00009392, ECO:0000256|HAMAP-Rule:MF_01020}.
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DR   EMBL; CP001578; ACU49046.1; -; Genomic_DNA.
DR   RefSeq; WP_002965152.1; NC_013119.1.
DR   AlphaFoldDB; C7LEW1; -.
DR   SMR; C7LEW1; -.
DR   GeneID; 93017603; -.
DR   KEGG; bmr:BMI_I2108; -.
DR   HOGENOM; CLU_123337_1_1_5; -.
DR   PhylomeDB; C7LEW1; -.
DR   UniPathway; UPA00031; UER00007.
DR   Proteomes; UP000002188; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004636; F:phosphoribosyl-ATP diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000105; P:L-histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd11534; NTP-PPase_HisIE_like; 1.
DR   Gene3D; 1.10.287.1080; MazG-like; 1.
DR   HAMAP; MF_01020; HisE; 1.
DR   InterPro; IPR008179; HisE.
DR   InterPro; IPR021130; PRib-ATP_PPHydrolase-like.
DR   NCBIfam; TIGR03188; histidine_hisI; 1.
DR   NCBIfam; NF001613; PRK00400.1-5; 1.
DR   PANTHER; PTHR42945; HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN; 1.
DR   PANTHER; PTHR42945:SF9; HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HISIE; 1.
DR   Pfam; PF01503; PRA-PH; 1.
DR   SUPFAM; SSF101386; all-alpha NTP pyrophosphatases; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605, ECO:0000256|HAMAP-
KW   Rule:MF_01020};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_01020};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01020};
KW   Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102, ECO:0000256|HAMAP-
KW   Rule:MF_01020};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01020};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_01020}; Reference proteome {ECO:0000313|Proteomes:UP000002188}.
SQ   SEQUENCE   107 AA;  11253 MW;  4335A80E49ACB391 CRC64;
     MSQFTLADLE RIVAERASVT DGTSYTASLV AKGQPKAAQK LGEEAVETVI AAVSGDRAGV
     VSESADLLYH LAVVWNIAGV ALEDVLQELQ RRTAQTGLAE KASRPKG
//