ID   C6CC33_MUSP7            Unreviewed;       228 AA.
AC   C6CC33;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   02-SEP-2026, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000256|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000256|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000256|HAMAP-Rule:MF_00759};
GN   OrderedLocusNames=Dd703_3019 {ECO:0000313|EMBL:ACS86793.1};
OS   Musicola paradisiaca (strain Ech703) (Dickeya paradisiaca) (Dickeya
OS   dadantii).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Pectobacteriaceae; Musicola.
OX   NCBI_TaxID=579405 {ECO:0000313|EMBL:ACS86793.1, ECO:0000313|Proteomes:UP000002734};
RN   [1] {ECO:0000313|EMBL:ACS86793.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ech703 {ECO:0000313|EMBL:ACS86793.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Dickeya dadantii Ech703.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated
CC       GATC sequences. It is involved in DNA mismatch repair.
CC       {ECO:0000256|HAMAP-Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000256|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; CP001654; ACS86793.1; -; Genomic_DNA.
DR   RefSeq; WP_015854694.1; NC_012880.1.
DR   AlphaFoldDB; C6CC33; -.
DR   STRING; 579405.Dd703_3019; -.
DR   KEGG; dda:Dd703_3019; -.
DR   eggNOG; COG3066; Bacteria.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   Proteomes; UP000002734; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH-like; 1.
DR   FunFam; 3.40.600.10:FF:000001; DNA mismatch repair protein MutH; 1.
DR   Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   NCBIfam; TIGR02248; mutH_TIGR; 1.
DR   NCBIfam; NF003458; PRK05070.1; 1.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00759};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00759};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00759};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW   Rule:MF_00759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00759};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00759};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002734}.
FT   DOMAIN          59..157
FT                   /note="DNA mismatch repair MutH/Type II restriction enzyme
FT                   Sau3AI"
FT                   /evidence="ECO:0000259|SMART:SM00927"
SQ   SEQUENCE   228 AA;  25345 MW;  692FA5AD4C8269D5 CRC64;
     MNIPMIHNDS PHSEQALAQR AQALAGYTLG ELARIAQLPI PPDLRRDKGW TGILLERFLG
     ASAGSKPEQD FPDIGVELKT IPVDSEGKPL ETTFVCVAPL TGNSGVTWEN SHVRHKLARV
     LWIPVEGARS IPLSQRHVGT PLLWSPSQKE EEQLRQDWEE LMDLIVLGKV ESITARHGEV
     LQLRPKAANS RILTEAIGEH GQPIMTLPRG FYLKKTFTAP LLARHFLL
//