ID   C0ZIX1_BREBN            Unreviewed;       503 AA.
AC   C0ZIX1;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   02-SEP-2026, entry version 69.
DE   SubName: Full=Putative acetyl-CoA hydrolase/transferase {ECO:0000313|EMBL:BAH41339.1};
DE            EC=2.8.3.8 {ECO:0000313|EMBL:BAH41339.1};
DE            EC=3.1.2.1 {ECO:0000313|EMBL:BAH41339.1};
GN   OrderedLocusNames=BBR47_03620 {ECO:0000313|EMBL:BAH41339.1};
OS   Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Caryophanales; Paenibacillaceae;
OC   Brevibacillus.
OX   NCBI_TaxID=358681 {ECO:0000313|EMBL:BAH41339.1, ECO:0000313|Proteomes:UP000001877};
RN   [1] {ECO:0000313|EMBL:BAH41339.1, ECO:0000313|Proteomes:UP000001877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=47 / JCM 6285 / NBRC 100599
RC   {ECO:0000313|Proteomes:UP000001877};
RA   Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W.,
RA   Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S.,
RA   Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.,
RA   Udaka S., Tanikawa S., Fujita N.;
RT   "Brevibacillus brevis strain 47, complete genome.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC       {ECO:0000256|ARBA:ARBA00009632}.
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DR   EMBL; AP008955; BAH41339.1; -; Genomic_DNA.
DR   RefSeq; WP_012684112.1; NC_012491.1.
DR   AlphaFoldDB; C0ZIX1; -.
DR   STRING; 358681.BBR47_03620; -.
DR   KEGG; bbe:BBR47_03620; -.
DR   eggNOG; COG0427; Bacteria.
DR   HOGENOM; CLU_019748_3_0_9; -.
DR   Proteomes; UP000001877; Chromosome.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   FunFam; 3.30.750.70:FF:000002; Acetyl-CoA hydrolase Ach1; 1.
DR   FunFam; 3.40.1080.20:FF:000001; Acetyl-CoA hydrolase Ach1; 1.
DR   Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR   Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR026888; AcetylCoA_hyd_C.
DR   InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR   InterPro; IPR046433; ActCoA_hydro.
DR   InterPro; IPR003702; ActCoA_hydro_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR017821; Succinate_CoA_transferase.
DR   NCBIfam; TIGR03458; YgfH_subfam; 1.
DR   PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR   PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR   Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR   Pfam; PF02550; AcetylCoA_hydro; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:BAH41339.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001877};
KW   Transferase {ECO:0000313|EMBL:BAH41339.1}.
FT   DOMAIN          8..216
FT                   /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02550"
FT   DOMAIN          326..464
FT                   /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13336"
FT   ACT_SITE        289
FT                   /note="5-glutamyl coenzyme A thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-1"
FT   BINDING         264..268
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         359
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         379
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         383
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         403
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
SQ   SEQUENCE   503 AA;  54752 MW;  6D985AAD90AF85AC CRC64;
     MWERLRDKRL ADKIVTAEVA AGWIEDGMTI GLSGFTRAGD AKVVPLALAE LAKKENKPFG
     VNVYTGASLG SDVDAVMAEA GIINKRLPFQ ADPVMRKKIN DGSMMFVDQH LSHTAEAIRQ
     GAIDAVDYAI VEAVAITEEG MIIPATSVGN SNIFVENAKH VIIELNMAQS VELEGIHDIY
     TPAKQGEREP IPLTSVDQRI GTAGIPVDPD KVKGIVLTNQ LDSPSTIVEP DEETAQIAAH
     LIEFLRQEVK EGRLPNNLAP LQSGIGSVAN AVFNGFLDSE FTDLTVFSEV LQDAVFDLLD
     AGKISFASGC SITLTAEKMK HVTENFAQYR DKLLLRPQEI TNHPELIRRL GLIAINTAIE
     ADIYGNVNST NVSGTRMMNG IGGSGDFARN ARLGIFVTKS IAKGGNISSI VPFASHVDHT
     EHDVDIIVTE QGLADLRGLA PRQRAIKIIE NCAHPMYRDQ LMAYYEEALT RGGHTPHVLE
     KAFSWHVRYA QEGTMLEKKP ALV
//