ID   Y4361_ARATH             Reviewed;        1136 AA.
AC   C0LGS2; O65510; Q8RXY8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   02-SEP-2026, entry version 116.
DE   RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At4g36180;
DE            EC=2.7.11.1;
DE   Flags: Precursor;
GN   OrderedLocusNames=At4g36180; ORFNames=F23E13.70;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Resource (TAIR);
RT   "Community-consensus reference genome of Arabidopsis thaliana Col-0.";
RL   Submitted (FEB-2026) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA   Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT   "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT   like protein kinase genes in Arabidopsis thaliana.";
RL   BMC Genomics 11:19-19(2010).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1136.
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=17644812; DOI=10.1074/mcp.m700099-mcp200;
RA   Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J.,
RA   Barbier-Brygoo H., Ephritikhine G.;
RT   "A high content in lipid-modified peripheral proteins and integral receptor
RT   kinases features in the arabidopsis plasma membrane proteome.";
RL   Mol. Cell. Proteomics 6:1980-1996(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC         H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC         ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- INTERACTION:
CC       C0LGS2; F4I065: At1g49100; NbExp=2; IntAct=EBI-16955302, EBI-20654598;
CC       C0LGS2; C0LGJ9: At2g02780; NbExp=2; IntAct=EBI-16955302, EBI-20651541;
CC       C0LGS2; C0LGL4: At2g28960; NbExp=2; IntAct=EBI-16955302, EBI-16946048;
CC       C0LGS2; O81069: At2g28990; NbExp=2; IntAct=EBI-16955302, EBI-16887698;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:17644812};
CC       Single-pass type I membrane protein {ECO:0000305|PubMed:17644812}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA18124.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAB81527.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL022141; CAA18124.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL161588; CAB81527.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002687; AEE86628.1; -; Genomic_DNA.
DR   EMBL; OZ408686; CAO7050107.1; -; Genomic_DNA.
DR   EMBL; FJ708764; ACN59357.1; -; mRNA.
DR   EMBL; AY080606; AAL86290.1; -; mRNA.
DR   PIR; T04587; T04587.
DR   RefSeq; NP_195341.2; NM_119785.4.
DR   AlphaFoldDB; C0LGS2; -.
DR   SMR; C0LGS2; -.
DR   BioGRID; 15057; 37.
DR   FunCoup; C0LGS2; 1133.
DR   IntAct; C0LGS2; 40.
DR   STRING; 3702.C0LGS2; -.
DR   GlyGen; C0LGS2; 22 sites.
DR   iPTMnet; C0LGS2; -.
DR   PaxDb; 3702-C0LGS2; -.
DR   ProteomicsDB; 242369; -.
DR   GeneID; 829775; -.
DR   KEGG; ath:AT4G36180; -.
DR   Araport; AT4G36180; -.
DR   TAIR; AT4G36180; -.
DR   eggNOG; ENOG502QTHE; Eukaryota.
DR   HOGENOM; CLU_000288_22_1_1; -.
DR   InParanoid; C0LGS2; -.
DR   OMA; TNNRVTE; -.
DR   PhylomeDB; C0LGS2; -.
DR   PRO; PR:C0LGS2; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IDA:TAIR.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   FunFam; 3.80.10.10:FF:000041; LRR receptor-like serine/threonine-protein kinase ERECTA; 1.
DR   FunFam; 3.80.10.10:FF:000101; LRR receptor-like serine/threonine-protein kinase ERECTA; 1.
DR   FunFam; 3.80.10.10:FF:000095; LRR receptor-like serine/threonine-protein kinase GSO1; 1.
DR   FunFam; 1.10.510.10:FF:000192; LRR receptor-like serine/threonine-protein kinase RPK2; 1.
DR   FunFam; 3.80.10.10:FF:000299; Piriformospora indica-insensitive protein 2; 1.
DR   FunFam; 3.30.200.20:FF:000404; Putative LRR receptor-like serine/threonine-protein kinase; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR013210; LRR_N_plant-typ.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR48052:SF63; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR48052; UNNAMED PRODUCT; 1.
DR   Pfam; PF00560; LRR_1; 8.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF08263; LRRNT_2; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00369; LRR_TYP; 13.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell membrane; Glycoprotein; Kinase; Leucine-rich repeat;
KW   Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome;
KW   Repeat; Serine/threonine-protein kinase; Signal; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..1136
FT                   /note="Probable LRR receptor-like serine/threonine-protein
FT                   kinase At4g36180"
FT                   /id="PRO_0000387557"
FT   TOPO_DOM        23..751
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        752..772
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        773..1136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          93..115
FT                   /note="LRR 1"
FT   REPEAT          117..139
FT                   /note="LRR 2"
FT   REPEAT          141..162
FT                   /note="LRR 3"
FT   REPEAT          163..186
FT                   /note="LRR 4"
FT   REPEAT          187..210
FT                   /note="LRR 5"
FT   REPEAT          211..233
FT                   /note="LRR 6"
FT   REPEAT          235..256
FT                   /note="LRR 7"
FT   REPEAT          259..280
FT                   /note="LRR 8"
FT   REPEAT          283..304
FT                   /note="LRR 9"
FT   REPEAT          309..330
FT                   /note="LRR 10"
FT   REPEAT          333..355
FT                   /note="LRR 11"
FT   REPEAT          357..379
FT                   /note="LRR 12"
FT   REPEAT          381..403
FT                   /note="LRR 13"
FT   REPEAT          405..426
FT                   /note="LRR 14"
FT   REPEAT          429..452
FT                   /note="LRR 15"
FT   REPEAT          453..479
FT                   /note="LRR 16"
FT   REPEAT          480..500
FT                   /note="LRR 17"
FT   REPEAT          501..524
FT                   /note="LRR 18"
FT   REPEAT          525..546
FT                   /note="LRR 19"
FT   REPEAT          549..571
FT                   /note="LRR 30"
FT   REPEAT          573..595
FT                   /note="LRR 21"
FT   REPEAT          597..620
FT                   /note="LRR 22"
FT   REPEAT          621..643
FT                   /note="LRR 23"
FT   REPEAT          645..666
FT                   /note="LRR 24"
FT   REPEAT          669..691
FT                   /note="LRR 25"
FT   REPEAT          694..716
FT                   /note="LRR 26"
FT   DOMAIN          841..1123
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          786..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..815
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         830
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O22476"
FT   MOD_RES         838
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O22476"
FT   MOD_RES         915
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:O22476"
FT   MOD_RES         1010
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:C0LGT6"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        192
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        232
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        281
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        365
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        441
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        474
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        477
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        482
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        511
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        535
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        554
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        594
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        631
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        669
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        679
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        699
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        719
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1136 AA;  123664 MW;  7AA32A277F6F2820 CRC64;
     MAMDISLFFI FLVIYAPLVS YADESQAEID ALTAFKLNLH DPLGALTSWD PSTPAAPCDW
     RGVGCTNHRV TEIRLPRLQL SGRISDRISG LRMLRKLSLR SNSFNGTIPT SLAYCTRLLS
     VFLQYNSLSG KLPPAMRNLT SLEVFNVAGN RLSGEIPVGL PSSLQFLDIS SNTFSGQIPS
     GLANLTQLQL LNLSYNQLTG EIPASLGNLQ SLQYLWLDFN LLQGTLPSAI SNCSSLVHLS
     ASENEIGGVI PAAYGALPKL EVLSLSNNNF SGTVPFSLFC NTSLTIVQLG FNAFSDIVRP
     ETTANCRTGL QVLDLQENRI SGRFPLWLTN ILSLKNLDVS GNLFSGEIPP DIGNLKRLEE
     LKLANNSLTG EIPVEIKQCG SLDVLDFEGN SLKGQIPEFL GYMKALKVLS LGRNSFSGYV
     PSSMVNLQQL ERLNLGENNL NGSFPVELMA LTSLSELDLS GNRFSGAVPV SISNLSNLSF
     LNLSGNGFSG EIPASVGNLF KLTALDLSKQ NMSGEVPVEL SGLPNVQVIA LQGNNFSGVV
     PEGFSSLVSL RYVNLSSNSF SGEIPQTFGF LRLLVSLSLS DNHISGSIPP EIGNCSALEV
     LELRSNRLMG HIPADLSRLP RLKVLDLGQN NLSGEIPPEI SQSSSLNSLS LDHNHLSGVI
     PGSFSGLSNL TKMDLSVNNL TGEIPASLAL ISSNLVYFNV SSNNLKGEIP ASLGSRINNT
     SEFSGNTELC GKPLNRRCES STAEGKKKKR KMILMIVMAA IGAFLLSLFC CFYVYTLLKW
     RKKLKQQSTT GEKKRSPGRT SAGSRVRSST SRSSTENGEP KLVMFNNKIT LAETIEATRQ
     FDEENVLSRT RYGLLFKANY NDGMVLSIRR LPNGSLLNEN LFKKEAEVLG KVKHRNITVL
     RGYYAGPPDL RLLVYDYMPN GNLSTLLQEA SHQDGHVLNW PMRHLIALGI ARGLGFLHQS
     NMVHGDIKPQ NVLFDADFEA HISDFGLDRL TIRSPSRSAV TANTIGTLGY VSPEATLSGE
     ITRESDIYSF GIVLLEILTG KRPVMFTQDE DIVKWVKKQL QRGQVTELLE PGLLELDPES
     SEWEEFLLGI KVGLLCTATD PLDRPTMSDV VFMLEGCRVG PDVPSSADPT SQPSPA
//