ID   B8IXM0_METNO            Unreviewed;       163 AA.
AC   B8IXM0;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   18-JUN-2025, entry version 83.
DE   RecName: Full=Ureidoglycolate lyase {ECO:0000256|HAMAP-Rule:MF_00616};
DE            EC=4.3.2.3 {ECO:0000256|HAMAP-Rule:MF_00616};
DE   AltName: Full=Ureidoglycolatase {ECO:0000256|HAMAP-Rule:MF_00616};
GN   Name=allA {ECO:0000256|HAMAP-Rule:MF_00616};
GN   OrderedLocusNames=Mnod_7820 {ECO:0000313|EMBL:ACL62852.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OG   Plasmid pMNOD02 {ECO:0000313|EMBL:ACL62852.1,
OG   ECO:0000313|Proteomes:UP000008207}.
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL62852.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RC   PLASMID=Plasmid pMNOD02 {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA   Richardson P.;
RT   "Complete sequence of plasmid 2 of Methylobacterium nodulans ORS 2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the catabolism of the allantoin degradation
CC       intermediate (S)-ureidoglycolate, generating urea and glyoxylate.
CC       Involved in the utilization of allantoin as nitrogen source.
CC       {ECO:0000256|HAMAP-Rule:MF_00616}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = urea + glyoxylate; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00047684, ECO:0000256|HAMAP-
CC         Rule:MF_00616};
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00616};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation.
CC       {ECO:0000256|HAMAP-Rule:MF_00616}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC       Rule:MF_00616}.
CC   -!- SIMILARITY: Belongs to the ureidoglycolate lyase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00616}.
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DR   EMBL; CP001351; ACL62852.1; -; Genomic_DNA.
DR   RefSeq; WP_012631058.1; NC_011887.1.
DR   AlphaFoldDB; B8IXM0; -.
DR   KEGG; mno:Mnod_7820; -.
DR   HOGENOM; CLU_070848_1_0_5; -.
DR   OrthoDB; 9804602at2; -.
DR   UniPathway; UPA00395; -.
DR   Proteomes; UP000008207; Plasmid pMNOD02.
DR   GO; GO:0004848; F:ureidoglycolate hydrolase activity; IEA:InterPro.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006145; P:purine nucleobase catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd20298; cupin_UAH; 1.
DR   Gene3D; 2.60.120.480; Ureidoglycolate hydrolase; 1.
DR   HAMAP; MF_00616; Ureidogly_lyase; 1.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR047233; UAH_cupin.
DR   InterPro; IPR007247; Ureidogly_lyase.
DR   InterPro; IPR023525; Ureidogly_lyase_bac.
DR   InterPro; IPR024060; Ureidoglycolate_lyase_dom_sf.
DR   NCBIfam; NF009932; PRK13395.1; 1.
DR   PANTHER; PTHR21221; UREIDOGLYCOLATE HYDROLASE; 1.
DR   PANTHER; PTHR21221:SF1; UREIDOGLYCOLATE LYASE; 1.
DR   Pfam; PF04115; Ureidogly_lyase; 1.
DR   PIRSF; PIRSF017306; Ureidogly_hydro; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ACL62852.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00616};
KW   Plasmid {ECO:0000313|EMBL:ACL62852.1};
KW   Purine metabolism {ECO:0000256|ARBA:ARBA00022631, ECO:0000256|HAMAP-
KW   Rule:MF_00616}; Reference proteome {ECO:0000313|Proteomes:UP000008207}.
SQ   SEQUENCE   163 AA;  18042 MW;  C644D141925238FE CRC64;
     MNTIVAQPLT REAFSPYGEV IDTEGADHFP INNGRCERYH ALARTDAIGP GARVIISIFK
     GAPYTLPLKL HMVERHPLGS QAFIPLSPRP FLVVVARDDG NRPGRPQAFL TRPGQGVNYP
     PNVWHGVLTP IGEPQDFLVV DRAGDGNNLE EFFFPEPYEI CLP
//