ID   B8GH80_METPE            Unreviewed;       411 AA.
AC   B8GH80;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   02-SEP-2026, entry version 80.
DE   SubName: Full=O-acetylhomoserine aminocarboxypropyltransferase {ECO:0000313|EMBL:ACL16485.1};
DE            EC=2.5.1.49 {ECO:0000313|EMBL:ACL16485.1};
GN   OrderedLocusNames=Mpal_1142 {ECO:0000313|EMBL:ACL16485.1};
OS   Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanomicrobiales; Methanoregulaceae; Methanosphaerula.
OX   NCBI_TaxID=521011 {ECO:0000313|EMBL:ACL16485.1, ECO:0000313|Proteomes:UP000002457};
RN   [1] {ECO:0000313|EMBL:ACL16485.1, ECO:0000313|Proteomes:UP000002457}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1556 / DSM 19958 / E1-9c
RC   {ECO:0000313|Proteomes:UP000002457};
RX   PubMed=26543115; DOI=10.1128/genomea.01280-15;
RA   Cadillo-Quiroz H., Browne P., Kyrpides N., Woyke T., Goodwin L., Detter C.,
RA   Yavitt J.B., Zinder S.H.;
RT   "Complete Genome Sequence of Methanosphaerula palustris E1-9CT, a
RT   Hydrogenotrophic Methanogen Isolated from a Minerotrophic Fen Peatland.";
RL   Genome Announc. 3:e01280-15(2015).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077}.
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DR   EMBL; CP001338; ACL16485.1; -; Genomic_DNA.
DR   RefSeq; WP_012617804.1; NC_011832.1.
DR   AlphaFoldDB; B8GH80; -.
DR   STRING; 521011.Mpal_1142; -.
DR   GeneID; 7270406; -.
DR   KEGG; mpl:Mpal_1142; -.
DR   eggNOG; arCOG00061; Archaea.
DR   HOGENOM; CLU_018986_4_0_2; -.
DR   Proteomes; UP000002457; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0004124; F:cysteine synthase activity; IEA:TreeGrafter.
DR   GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0071269; P:L-homocysteine biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   FunFam; 3.40.640.10:FF:000046; Cystathionine gamma-lyase; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002457};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACL16485.1}.
SQ   SEQUENCE   411 AA;  44449 MW;  0FA9EA3CD15B9B05 CRC64;
     MKHPGFTTRA VHGPLTGKDP NHALQFPIYA GVAHDFETAE TMADTFAGRK AAFAYSRIAN
     PTVSAFERKI TALEDGLGTV AVSSGMAAIS NTLLNLLTEG DTLVAASSLF GGTYSLFINV
     FQPLGINVKF VSITDLDGLD AAIDENTRVL FLETISNPCT TIPDFERISE IASRHHVVVV
     ADSTATTPYL FPARRFGVNI VIHSTTKYIS GGATSMGGAI VDLGNFDWSF VPALKKYHRY
     KEMAFLARLR KEVYQETGSC LSPYDAYLQS LGLETLALRM EQICKNAQAV AEFLEAQNVV
     TTVFYPGLPS SQSQELAKKQ LNGKCGGILA FGLSDRTACF RFLDKLSLIK RASNLGDNKT
     LALHPASTIF AGLNTDEQKT LGIDDTLIRL SIGIEDADDI IADIRQALGE S
//