ID   B8GDG9_METPE            Unreviewed;       383 AA.
AC   B8GDG9;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   02-SEP-2026, entry version 83.
DE   RecName: Full=phosphoglycerate mutase (2,3-diphosphoglycerate-independent) {ECO:0000256|ARBA:ARBA00012026};
DE            EC=5.4.2.12 {ECO:0000256|ARBA:ARBA00012026};
GN   OrderedLocusNames=Mpal_2019 {ECO:0000313|EMBL:ACL17320.1};
OS   Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanomicrobiales; Methanoregulaceae; Methanosphaerula.
OX   NCBI_TaxID=521011 {ECO:0000313|EMBL:ACL17320.1, ECO:0000313|Proteomes:UP000002457};
RN   [1] {ECO:0000313|EMBL:ACL17320.1, ECO:0000313|Proteomes:UP000002457}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1556 / DSM 19958 / E1-9c
RC   {ECO:0000313|Proteomes:UP000002457};
RX   PubMed=26543115; DOI=10.1128/genomea.01280-15;
RA   Cadillo-Quiroz H., Browne P., Kyrpides N., Woyke T., Goodwin L., Detter C.,
RA   Yavitt J.B., Zinder S.H.;
RT   "Complete Genome Sequence of Methanosphaerula palustris E1-9CT, a
RT   Hydrogenotrophic Methanogen Isolated from a Minerotrophic Fen Peatland.";
RL   Genome Announc. 3:e01280-15(2015).
CC   -!- FUNCTION: Catalyzes the interconversion of 2-phosphoglycerate and 3-
CC       phosphoglycerate. {ECO:0000256|ARBA:ARBA00002315}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate;
CC         Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289;
CC         EC=5.4.2.12; Evidence={ECO:0000256|ARBA:ARBA00000370};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 3/5. {ECO:0000256|ARBA:ARBA00004798}.
CC   -!- SIMILARITY: Belongs to the BPG-independent phosphoglycerate mutase
CC       family. A-PGAM subfamily. {ECO:0000256|ARBA:ARBA00005524}.
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DR   EMBL; CP001338; ACL17320.1; -; Genomic_DNA.
DR   RefSeq; WP_012618639.1; NC_011832.1.
DR   AlphaFoldDB; B8GDG9; -.
DR   STRING; 521011.Mpal_2019; -.
DR   GeneID; 7272000; -.
DR   KEGG; mpl:Mpal_2019; -.
DR   eggNOG; arCOG01696; Archaea.
DR   HOGENOM; CLU_034906_2_0_2; -.
DR   OrthoDB; 52918at2157; -.
DR   UniPathway; UPA00109; UER00186.
DR   Proteomes; UP000002457; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004619; F:phosphoglycerate mutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd16011; iPGM_like; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR023665; ApgAM_prokaryotes.
DR   InterPro; IPR006124; Metalloenzyme.
DR   InterPro; IPR004456; Pglycerate_mutase_ApgM.
DR   NCBIfam; TIGR00306; apgM; 1.
DR   NCBIfam; TIGR02535; hyp_Hser_kinase; 1.
DR   NCBIfam; NF003242; PRK04200.1; 1.
DR   PANTHER; PTHR31209:SF4; 2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE; 1.
DR   PANTHER; PTHR31209; COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE; 1.
DR   Pfam; PF01676; Metalloenzyme; 1.
DR   Pfam; PF10143; PhosphMutase; 1.
DR   PIRSF; PIRSF006392; IPGAM_arch; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   3: Inferred from homology;
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Kinase {ECO:0000313|EMBL:ACL17320.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002457};
KW   Transferase {ECO:0000313|EMBL:ACL17320.1}.
FT   DOMAIN          1..375
FT                   /note="Metalloenzyme"
FT                   /evidence="ECO:0000259|Pfam:PF01676"
SQ   SEQUENCE   383 AA;  41562 MW;  9D8F1DD651A7E91E CRC64;
     MKYLLVLGDG MADEPIPELG NRTPLAYANT PNMDRIAREG RSGQVQTVPD GFEPGSDVAN
     LSILGYHPAR FYTGRGPLEA VNMGVDLTDD QIAYRCNLVT IRDGVMQDFS AGHITSAEGA
     ALFKSLQEYL PEVKLVSGVS YRNLLVVDRG RGAEGKAPHD IVGEEIEQYL PHGEDAPLLR
     ACIEKSIEVF ADHPVNRDRL ARGLPAATMI WPWSGGKRPA LIPFQEKYGK KGGMISAVDL
     LNGIARYADM KVITVPGATG YLDTDYQAKA RYAIEALKDL DFLYLHVEAP DEAGHLGSLK
     EKVKAIERVD EMIGTIMAGF DGVIAVLPDH ATPIRLKTHT RGPVPCAVLG KGKDETEVFS
     EEAAANGSLG MIRGDLFLTE LFS
//