ID   B7LEX7_ECO55            Unreviewed;       455 AA.
AC   B7LEX7;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   02-SEP-2026, entry version 71.
DE   RecName: Full=L-serine dehydratase {ECO:0000256|RuleBase:RU366059};
DE            EC=4.3.1.17 {ECO:0000256|RuleBase:RU366059};
GN   Name=sdaB {ECO:0000313|EMBL:CAU98969.1};
GN   OrderedLocusNames=EC55989_3076 {ECO:0000313|EMBL:CAU98969.1};
OS   Escherichia coli (strain 55989 / EAEC).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585055 {ECO:0000313|EMBL:CAU98969.1, ECO:0000313|Proteomes:UP000000746};
RN   [1] {ECO:0000313|Proteomes:UP000000746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=55989 / EAEC {ECO:0000313|Proteomes:UP000000746};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = pyruvate + NH4(+); Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00049406,
CC         ECO:0000256|RuleBase:RU366059};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU366059};
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00008636, ECO:0000256|RuleBase:RU366059}.
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DR   EMBL; CU928145; CAU98969.1; -; Genomic_DNA.
DR   RefSeq; WP_000626410.1; NC_011748.1.
DR   AlphaFoldDB; B7LEX7; -.
DR   SMR; B7LEX7; -.
DR   GeneID; 93779201; -.
DR   KEGG; eck:EC55989_3076; -.
DR   HOGENOM; CLU_022305_0_1_6; -.
DR   Proteomes; UP000000746; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009063; P:amino acid catabolic process; IEA:UniProtKB-ARBA.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR   FunFam; 3.30.1330.90:FF:000001; L-serine ammonia-lyase 1; 1.
DR   Gene3D; 3.30.1330.90; D-3-phosphoglycerate dehydrogenase, domain 3; 1.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR051318; Fe-S_L-Ser.
DR   InterPro; IPR004644; Fe-S_L-Ser_mono.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR005131; Ser_deHydtase_bsu.
DR   NCBIfam; TIGR00720; sda_mono; 1.
DR   PANTHER; PTHR30182; L-SERINE DEHYDRATASE; 1.
DR   PANTHER; PTHR30182:SF14; L-SERINE DEHYDRATASE 2; 1.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   Pfam; PF03315; SDH_beta; 1.
DR   SUPFAM; SSF143548; Serine metabolism enzymes domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU366059};
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU366059};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU366059};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU366059};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366059};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU366059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000746}.
FT   DOMAIN          3..155
FT                   /note="Serine dehydratase beta chain"
FT                   /evidence="ECO:0000259|Pfam:PF03315"
FT   DOMAIN          183..448
FT                   /note="Serine dehydratase-like alpha subunit"
FT                   /evidence="ECO:0000259|Pfam:PF03313"
SQ   SEQUENCE   455 AA;  48722 MW;  99B0D492F6AF9E7D CRC64;
     MISVFDIFKI GIGPSSSHTV GPMKAGKQFT DDLIARNLLK DVTRVVVDVY GSLSLTGKGH
     HTDIAIIMGL AGNLPDTVDI DSIPGFIQDV NTHGRLMLAN GQHEVEFPVD QCMNFHADNL
     SLHENGMRIT ALAGDKVVYS QTYYSIGGGF IVDEEHFGQQ NSAPVEVPYP YSSAADLQKH
     CQETGLSLSG LMMKNELALH SKEELEQHLA NVWEVMRGGI ERGISTEGVL PGKLRVPRRA
     AALRRMLVSQ DKTTTDPMAV VDWINMFALA VNEENAAGGR VVTAPTNGAC GIIPAVLAYY
     DKFIREVNAN SLARYLLVAS AIGSLYKMNA SISGAEVGCQ GEVGVACSMA AAGLAELLGA
     SPAQVCIAAE IAMEHNLGLT CDPVAGQVQV PCIERNAIAA VKAVNAARMA LRRTSEPRVC
     LDKVIETMYE TGKDMNAKYR ETSRGGLAMK IVACD
//