ID   B7LE12_ECO55            Unreviewed;       245 AA.
AC   B7LE12;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   02-SEP-2026, entry version 73.
DE   RecName: Full=Replicative helicase loader DnaC {ECO:0000256|ARBA:ARBA00044977};
DE   AltName: Full=DNA replication protein DnaC {ECO:0000256|ARBA:ARBA00045009};
GN   Name=dnaC {ECO:0000313|EMBL:CAV02147.1};
GN   OrderedLocusNames=EC55989_5023 {ECO:0000313|EMBL:CAV02147.1};
OS   Escherichia coli (strain 55989 / EAEC).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585055 {ECO:0000313|EMBL:CAV02147.1, ECO:0000313|Proteomes:UP000000746};
RN   [1] {ECO:0000313|Proteomes:UP000000746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=55989 / EAEC {ECO:0000313|Proteomes:UP000000746};
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00048778};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC         Evidence={ECO:0000256|ARBA:ARBA00048778};
CC   -!- SIMILARITY: Belongs to the DnaC family.
CC       {ECO:0000256|ARBA:ARBA00038338}.
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DR   EMBL; CU928145; CAV02147.1; -; Genomic_DNA.
DR   RefSeq; WP_000799913.1; NC_011748.1.
DR   AlphaFoldDB; B7LE12; -.
DR   KEGG; eck:EC55989_5023; -.
DR   HOGENOM; CLU_062999_3_1_6; -.
DR   Proteomes; UP000000746; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:TreeGrafter.
DR   CDD; cd00009; AAA; 1.
DR   FunFam; 3.40.50.300:FF:000266; DNA replication protein DnaC; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR028350; DNAC/IstB-like.
DR   InterPro; IPR002611; IstB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; NF005931; PRK07952.1; 1.
DR   PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   PANTHER; PTHR30050:SF9; DNA REPLICATION PROTEIN DNAC; 1.
DR   Pfam; PF01695; IstB_IS21; 1.
DR   PIRSF; PIRSF003073; DNAC_TnpB_IstB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000746}.
FT   DOMAIN          98..227
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   245 AA;  27965 MW;  B4106FF33E1ED1E4 CRC64;
     MKNVGDLMQR LQKMMPAHIK PAFKTGEELL AWQKEQGAIR SAALERENRA MKMQRTFNRS
     GIRPLHQNCS FENYRVECEG QMNALSKARQ YVEEFDGNIA SFIFSGKPGT GKNHLAAAIC
     NELLLRGKSV LIITVADIMS AMKDTFRNSS TSEEQLLNDL SNVDLLVIDE IGVQTESKYE
     KVIINQIVDR RSSSKRPTGM LTNSNMEEMT KLLGERVMDR MRLGNSLWVI FNWDSYRSRV
     TGKEY
//