ID B4RAS0_PHEZH Unreviewed; 887 AA. AC B4RAS0; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 02-SEP-2026, entry version 82. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=PHZ_c3259 {ECO:0000313|EMBL:ACG79668.1}; OS Phenylobacterium zucineum (strain HLK1). OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria; OC Caulobacterales; Caulobacteraceae; Phenylobacterium. OX NCBI_TaxID=450851 {ECO:0000313|EMBL:ACG79668.1, ECO:0000313|Proteomes:UP000001868}; RN [1] {ECO:0000313|EMBL:ACG79668.1, ECO:0000313|Proteomes:UP000001868} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HLK1 {ECO:0000313|EMBL:ACG79668.1, RC ECO:0000313|Proteomes:UP000001868}; RX PubMed=18700039; DOI=10.1186/1471-2164-9-386; RA Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.; RT "Complete genome of Phenylobacterium zucineum - a novel facultative RT intracellular bacterium isolated from human erythroleukemia cell line RT K562."; RL BMC Genomics 9:386-386(2008). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000747; ACG79668.1; -; Genomic_DNA. DR RefSeq; WP_012523806.1; NC_011144.1. DR AlphaFoldDB; B4RAS0; -. DR STRING; 450851.PHZ_c3259; -. DR KEGG; pzu:PHZ_c3259; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_1_5; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000001868; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0006310; P:DNA recombination; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR052171; NHEJ_LigD. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR NCBIfam; NF004628; PRK05972.1; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACG79668.1}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000001868}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 334..429 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 190..233 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 537..587 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 557..575 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 576..586 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 887 AA; 97425 MW; 134DDB14B92DA028 CRC64; MADKLARYRA MRDFSKTAEP AGAEKTKASR RLRFVIQKHA ATRLHYDFRL ELDGVFLSWA VTKGPSLNPA DRRLAVQTED HPLDYGDFEG TIPKGQYGGG TVMLWDRGYW EPEGDARAML KKGDLKFTLD GERLKGSWVL VRMKRREREK RDNWLLIKHH DGWSVEDHGE FLVEGETSSV ASGRAMDEIE AGKGKGPTKF MTGKGRASGK DVWQSNRADP KAPPPAAEKA APAPKLKAAA LPGFVAPQLA KSVDRPPQGA GWGHEIKFDG YRLQLRVENG KATLKTRAGL DWTAKFKEIA ADAKPLPDGL YDGEACALDH NGSPDFPALQ AALSEDRTAD LVFFVFDALF LDGEDLRALP LTERKSRLEA AVAAAGKRLE RRIRYVAHFE TAGDAVLKSA CRMSLEGIVS KRLDAPYRSG RSDTWQKSKC RAGHEVVIGG WTGERGQLRS LLVGVNRDGK LVYVGRVGTG FGRETVGRVL PRLEKVASDK SPFTGPNAPR KSGDINWARP ELVAEIEFAG FTGDGNVRQA SFKGLREDKP AAEVEAETPA KTQLAEPAPA GKAKAGPRTA PAKPATKPRA KPRAKPRAGD NVVMGVVLSN PDKALWPDDG KGGVVTKLDL ARYLETVGPW MMEHIKGRPC SIIRMPDGIE GQQRFFQRHA GKGSSALISE VQVFGDHKPY IQIDRIEALA ALAQIGAVEY HPWNCQPGQP EVPGRLVFDL DPDEAIPFQR VIDAAWEVKE RLESLGLAAF CKTTGGKGLH VVTPLKAGKG EMDWPTAKAF ARDVCLAIAA DAPDRYVVNM AKAKRKGRIF LDYLRNDRMS TAVAPLSPRG RPLAPVSFPL TWDQVKTGLE PKRWTIRTAP ALLKKTKAWA DYCDAERPLK DAIRKLK //