ID   B4EC45_BURCJ            Unreviewed;       337 AA.
AC   B4EC45;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   02-SEP-2026, entry version 85.
DE   RecName: Full=Probable allantoicase {ECO:0000256|HAMAP-Rule:MF_00813};
DE            EC=3.5.3.4 {ECO:0000256|HAMAP-Rule:MF_00813};
DE   AltName: Full=Allantoate amidinohydrolase {ECO:0000256|HAMAP-Rule:MF_00813};
GN   Name=alc {ECO:0000256|HAMAP-Rule:MF_00813};
GN   ORFNames=BCAL2038 {ECO:0000313|EMBL:CAR52338.1};
OS   Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS   NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC   Burkholderiales; Burkholderiaceae; Burkholderia;
OC   Burkholderia cepacia complex.
OX   NCBI_TaxID=216591 {ECO:0000313|EMBL:CAR52338.1, ECO:0000313|Proteomes:UP000001035};
RN   [1] {ECO:0000313|EMBL:CAR52338.1, ECO:0000313|Proteomes:UP000001035}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
RC   CF5610 {ECO:0000313|Proteomes:UP000001035};
RX   PubMed=18931103; DOI=10.1128/JB.01230-08;
RA   Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA   Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA   Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA   Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA   Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA   Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT   "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT   cystic fibrosis patients.";
RL   J. Bacteriol. 191:261-277(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=allantoate + H2O = (S)-ureidoglycolate + urea;
CC         Xref=Rhea:RHEA:11016, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:17536, ChEBI:CHEBI:57296; EC=3.5.3.4;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00813};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-
CC       ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_00813}.
CC   -!- SIMILARITY: Belongs to the allantoicase family.
CC       {ECO:0000256|ARBA:ARBA00009242, ECO:0000256|HAMAP-Rule:MF_00813}.
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DR   EMBL; AM747720; CAR52338.1; -; Genomic_DNA.
DR   RefSeq; WP_006490198.1; NC_011000.1.
DR   AlphaFoldDB; B4EC45; -.
DR   GeneID; 56558521; -.
DR   KEGG; bcj:BCAL2038; -.
DR   eggNOG; COG4266; Bacteria.
DR   HOGENOM; CLU_038797_1_2_4; -.
DR   BioCyc; BCEN216591:G1G1V-2237-MONOMER; -.
DR   UniPathway; UPA00395; UER00654.
DR   Proteomes; UP000001035; Chromosome 1.
DR   GO; GO:0004037; F:allantoicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   FunFam; 2.60.120.260:FF:000059; Probable allantoicase; 1.
DR   FunFam; 2.60.120.260:FF:000090; Probable allantoicase; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   HAMAP; MF_00813; Allantoicase; 1.
DR   InterPro; IPR005164; Allantoicase.
DR   InterPro; IPR015908; Allantoicase_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   NCBIfam; TIGR02961; allantoicase; 1.
DR   PANTHER; PTHR12045; ALLANTOICASE; 1.
DR   PANTHER; PTHR12045:SF3; INACTIVE ALLANTOICASE-RELATED; 1.
DR   Pfam; PF03561; Allantoicase; 2.
DR   PIRSF; PIRSF016516; Allantoicase; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00813};
KW   Purine metabolism {ECO:0000256|ARBA:ARBA00022631, ECO:0000256|HAMAP-
KW   Rule:MF_00813}; Reference proteome {ECO:0000313|Proteomes:UP000001035}.
FT   DOMAIN          18..172
FT                   /note="Allantoicase"
FT                   /evidence="ECO:0000259|Pfam:PF03561"
FT   DOMAIN          185..334
FT                   /note="Allantoicase"
FT                   /evidence="ECO:0000259|Pfam:PF03561"
SQ   SEQUENCE   337 AA;  37304 MW;  6475D24F2CFED728 CRC64;
     MAVPLLDPNA PDFTRRYVNL ADPRLGAQAL EASDDFFAPK DRMLNPEPAV FIPGKYDDHG
     KWMDGWETRR KRTTGYDWCI VKLARPGVIK GFDIDTSHFT GNFPPAASIE AAFVADGAPT
     HATEWVEIVP STTLQGNSHH YVEAHDARAF THLRVNIYPD GGIARLRVYG QPQLDWAGAS
     ATEQFDLAAM ENGGYVVAAN NQHFGVASNL LLPGRGVNMG DGWETRRRRE PGNDWAIIAL
     AQPGVIRKIE VDTAFFKGNY PDRCSIQAAY VSGGTDSSLI TQSMFWPVLL GEQKLQMDKQ
     HYFEQDIASL GPVTHVRLNI IPDGGVSRLR LWGTLDK
//