ID   B4EC44_BURCJ            Unreviewed;       170 AA.
AC   B4EC44;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-OCT-2025, entry version 89.
DE   RecName: Full=Ureidoglycolate lyase {ECO:0000256|HAMAP-Rule:MF_00616};
DE            EC=4.3.2.3 {ECO:0000256|HAMAP-Rule:MF_00616};
DE   AltName: Full=Ureidoglycolatase {ECO:0000256|HAMAP-Rule:MF_00616};
GN   Name=allA {ECO:0000256|HAMAP-Rule:MF_00616};
GN   ORFNames=BCAL2037 {ECO:0000313|EMBL:CAR52337.1};
OS   Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS   NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC   Burkholderiales; Burkholderiaceae; Burkholderia;
OC   Burkholderia cepacia complex.
OX   NCBI_TaxID=216591 {ECO:0000313|EMBL:CAR52337.1, ECO:0000313|Proteomes:UP000001035};
RN   [1] {ECO:0000313|EMBL:CAR52337.1, ECO:0000313|Proteomes:UP000001035}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
RC   CF5610 {ECO:0000313|Proteomes:UP000001035};
RX   PubMed=18931103; DOI=10.1128/JB.01230-08;
RA   Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA   Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA   Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA   Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA   Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA   Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT   "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT   cystic fibrosis patients.";
RL   J. Bacteriol. 191:261-277(2009).
CC   -!- FUNCTION: Catalyzes the catabolism of the allantoin degradation
CC       intermediate (S)-ureidoglycolate, generating urea and glyoxylate.
CC       Involved in the utilization of allantoin as nitrogen source.
CC       {ECO:0000256|HAMAP-Rule:MF_00616}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = urea + glyoxylate; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00047684, ECO:0000256|HAMAP-
CC         Rule:MF_00616};
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00616};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation.
CC       {ECO:0000256|HAMAP-Rule:MF_00616}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC       Rule:MF_00616}.
CC   -!- SIMILARITY: Belongs to the ureidoglycolate lyase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00616}.
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DR   EMBL; AM747720; CAR52337.1; -; Genomic_DNA.
DR   RefSeq; WP_006490209.1; NC_011000.1.
DR   AlphaFoldDB; B4EC44; -.
DR   KEGG; bcj:BCAL2037; -.
DR   eggNOG; COG3194; Bacteria.
DR   HOGENOM; CLU_070848_1_0_4; -.
DR   BioCyc; BCEN216591:G1G1V-2236-MONOMER; -.
DR   UniPathway; UPA00395; -.
DR   Proteomes; UP000001035; Chromosome 1.
DR   GO; GO:0004848; F:ureidoglycolate hydrolase activity; IEA:InterPro.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006145; P:purine nucleobase catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd20298; cupin_UAH; 1.
DR   Gene3D; 2.60.120.480; Ureidoglycolate hydrolase; 1.
DR   HAMAP; MF_00616; Ureidogly_lyase; 1.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR047233; UAH_cupin.
DR   InterPro; IPR007247; Ureidogly_lyase.
DR   InterPro; IPR023525; Ureidogly_lyase_bac.
DR   InterPro; IPR024060; Ureidoglycolate_lyase_dom_sf.
DR   NCBIfam; NF002950; PRK03606.1-3; 1.
DR   NCBIfam; NF009932; PRK13395.1; 1.
DR   PANTHER; PTHR21221; UREIDOGLYCOLATE HYDROLASE; 1.
DR   PANTHER; PTHR21221:SF1; UREIDOGLYCOLATE LYASE; 1.
DR   Pfam; PF04115; Ureidogly_lyase; 1.
DR   PIRSF; PIRSF017306; Ureidogly_hydro; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:CAR52337.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00616};
KW   Purine metabolism {ECO:0000256|ARBA:ARBA00022631, ECO:0000256|HAMAP-
KW   Rule:MF_00616}; Reference proteome {ECO:0000313|Proteomes:UP000001035}.
SQ   SEQUENCE   170 AA;  18513 MW;  CE61ABFA04B8F376 CRC64;
     MKTLAIEPLT KEAFAPFGDV IETEGAKQIP INLGTTIRFH DLAKVDVTDE GGRTLVNLFR
     GQPRTLPFEV KMLERHPLGS QAFVPLNDQP YLVVVAPAGD LDPAKIRAFV TSGWQGVNYA
     KGVWHHPLIA LGGVSDFIVV DRGGDGLNLN EQDLQESLWL TEDALDAVTA
//