ID   B3STT8_RAT              Unreviewed;       201 AA.
AC   B3STT8;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   04-NOV-2026, entry version 74.
DE   SubName: Full=Neuroprotective protein 2 {ECO:0000313|EMBL:ABX10433.1};
GN   Name=Arl4d {ECO:0000313|RGD:1306875};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:ABX10433.1};
RN   [1] {ECO:0000313|EMBL:ABX10433.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Crl:CD {ECO:0000313|EMBL:ABX10433.1};
RX   PubMed=21124846; DOI=10.1371/journal.pone.0015008;
RA   Dai C., Liang D., Li H., Sasaki M., Dawson T.M., Dawson V.L.;
RT   "Functional identification of neuroprotective molecules.";
RL   PLoS ONE 5:E15008-E15008(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000256|ARBA:ARBA00010290, ECO:0000256|RuleBase:RU003925}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000256|PROSITE-ProRule:PRU00753}.
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DR   EMBL; EF688597; ABX10433.1; -; mRNA.
DR   UCSC; RGD:1306875; rat.
DR   AGR; RGD:1306875; -.
DR   RGD; 1306875; Arl4d.
DR   OMA; APGPPFM; -.
DR   PhylomeDB; B3STT8; -.
DR   FunFam; 3.40.50.300:FF:000458; ADP-ribosylation factor-like protein 4C; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   AlphaFoldDB; B3STT8; -.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR606689-
KW   1}; Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR606689-2};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR606689-2};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRSR:PIRSR606689-1}.
FT   REGION          47..55
FT                   /note="Switch-I"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00753"
FT   REGION          79..95
FT                   /note="Switch-II"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00753"
FT   BINDING         28..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-1"
FT   BINDING         35
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-2"
FT   BINDING         52
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-2"
FT   BINDING         79
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-1"
FT   BINDING         135..138
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-1"
SQ   SEQUENCE   201 AA;  22228 MW;  A79A2A22B3AE753D CRC64;
     MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI
     RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDSAETERLE EARMELHRIS
     KASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VGGLGLQLGL
     EHLYEMILKR KKAPRSSKKR R
//