ID   B3KVM5_HUMAN            Unreviewed;       322 AA.
AC   B3KVM5;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   02-SEP-2026, entry version 80.
DE   SubName: Full=cDNA FLJ16751 fis, clone BEAST2001444, highly similar to Orphan nuclear receptor PXR {ECO:0000313|EMBL:BAG53837.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG53837.1};
RN   [1] {ECO:0000313|EMBL:BAG53837.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Breast {ECO:0000313|EMBL:BAG53837.1};
RA   Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., Arita M.,
RA   Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., Otsuki T., Sato H.,
RA   Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K.,
RA   Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M.,
RA   Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A.,
RA   Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K.,
RA   Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008092}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK122990; BAG53837.1; -; mRNA.
DR   AlphaFoldDB; B3KVM5; -.
DR   PeptideAtlas; B3KVM5; -.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-ARBA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-ARBA.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR   CDD; cd06934; NR_LBD_PXR_like; 1.
DR   FunFam; 1.10.565.10:FF:000024; Nuclear receptor subfamily 1 group I member 2; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR050234; Nuclear_hormone_rcpt_NR1.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24082:SF39; NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   SMART; SM00430; HOLI; 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PROSITE-
KW   ProRule:PRU01189}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          34..321
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          310..321
FT                   /note="AF-2"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01189"
SQ   SEQUENCE   322 AA;  36950 MW;  17FC53AC3342C1B1 CRC64;
     MSDEAVEERR ALIKRKKSER TGTQPLGVQG LTEEQRMMIR ELMDAQMKTF DTTFSHFKNF
     RLPGVLSSGC ELPESLQAPS REEAAKWSQV RKDLCSLKVS LQLRGEDGSV WNYKPPADSG
     GKEIFSLLPH MADMSTYMFK GIISFAKVIS YFRDLPIEDQ ISLLKGAAFE LCQLRFNTVF
     NAETGTWECG RLSYCLEDTA GGFQQLLLEP MLKFHYMLKK LQLHEEEYVL MQAISLFSPD
     RPGVLQHRVV DQLQEQFAIT LKSYIECNRP QPAHRFLFLK IMAMLTELRS INAQHTQRLL
     RIQDIHPFAT PLMQELFGIT GS
//