ID   B2UN71_AKKM8            Unreviewed;       395 AA.
AC   B2UN71;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   04-NOV-2026, entry version 76.
DE   SubName: Full=Glycoside hydrolase family 57 {ECO:0000313|EMBL:ACD05682.1};
GN   OrderedLocusNames=Amuc_1868 {ECO:0000313|EMBL:ACD05682.1};
OS   Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS   81048 / CCUG 64013 / CIP 107961 / Muc).
OC   Bacteria; Pseudomonadati; Verrucomicrobiota; Verrucomicrobiia;
OC   Verrucomicrobiales; Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05682.1, ECO:0000313|Proteomes:UP000001031};
RN   [1] {ECO:0000313|Proteomes:UP000001031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC   / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 57 family.
CC       {ECO:0000256|ARBA:ARBA00006821}.
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DR   EMBL; CP001071; ACD05682.1; -; Genomic_DNA.
DR   RefSeq; WP_012420896.1; NC_010655.1.
DR   AlphaFoldDB; B2UN71; -.
DR   STRING; 349741.Amuc_1868; -.
DR   PaxDb; 349741-Amuc_1868; -.
DR   GeneID; 60881455; -.
DR   KEGG; amu:Amuc_1868; -.
DR   eggNOG; COG1449; Bacteria.
DR   HOGENOM; CLU_033691_0_0_0; -.
DR   OMA; AAKCYIP; -.
DR   OrthoDB; 138256at2; -.
DR   BioCyc; AMUC349741:G1GBX-1994-MONOMER; -.
DR   Proteomes; UP000001031; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd10795; GH57N_MJA1_like; 1.
DR   Gene3D; 3.20.110.20; -; 1.
DR   InterPro; IPR052046; GH57.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR004300; Glyco_hydro_57_N.
DR   PANTHER; PTHR36306:SF1; ALPHA-AMYLASE-RELATED; 1.
DR   PANTHER; PTHR36306; ALPHA-AMYLASE-RELATED-RELATED; 1.
DR   Pfam; PF03065; Glyco_hydro_57; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Hydrolase {ECO:0000313|EMBL:ACD05682.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001031}.
FT   DOMAIN          6..287
FT                   /note="Glycoside hydrolase family 57 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03065"
SQ   SEQUENCE   395 AA;  45095 MW;  10AA994C3AF24E97 CRC64;
     MSNISLTFVA HQPNRLIHYD FFKIGEHAFY EDDDLNARVL STVAERCYFP ATRLMKQLIE
     LTGGKFRFGL ALSGVILEQA LYHRPDLIAA FKDLAETGCV DFLAMPYYNS LASVYSPQEF
     AEQIEEHREL LKKLFHQETD VLMNTGMLYS NAIAAQAETL GFKGIMADGN PAMLKGFTSN
     EVFLAPWVYN TTTIFRNREL SNDLAIMRTD PEWSEYPLSP TTFADWLTHQ QGSVTTLSMD
     YETLGERQSD ATGVFEFWRT MILACIDAGN RFMTPSEVAQ EIKPVSVCEC TQEMTCSTFG
     TMSHWNGNVM QDEALRKIYR LEKPVKAAHD KDLTHVWRKL QSADHFHYMQ KENSFTPYAS
     AFDAYIYYMN ALADLQIRVK RESGKPVQPD PEKAS
//