ID   F16PC_CLOBB             Reviewed;         663 AA.
AC   B2TNB5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   02-SEP-2026, entry version 83.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854};
GN   OrderedLocusNames=CLL_A2533;
OS   Clostridium botulinum (strain Eklund 17B / Type B).
OC   Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium; Clostridium botulinum group.
OX   NCBI_TaxID=935198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Eklund 17B / Type B;
RA   Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Complete sequence of Clostridium botulinum strain Eklund.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP001056; ACD23440.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2TNB5; -.
DR   KEGG; cbk:CLL_A2533; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..663
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363082"
SQ   SEQUENCE   663 AA;  77060 MW;  93A54288BF995B0A CRC64;
     MEVKMNKNEQ EDSKKLKYFR LLAKQYPNIA LASTEIINLE AILNLPKGTE HFLSDIHGEY
     EPFVHVLRNG SGVVKRKIED LFCKSLLESD IKSLATLIYY PEQKLDIVLK EERNIDDWYK
     ITLNRLIEIC RFCSSKYTRS KVRKALPADF AYIIEELLHE QFNGIDKEEY YDRIITTIID
     IGRAKEFIIA LSKLIQRMII DRLHIIGDIY DRGPRPDIII DTLMEYHSVD IQWGNHDMLW
     MGAAAGVRTC VANVLRISTR YANLDLVEEI YGINLLPLAT FALKYYRDDP CESFIPKVKE
     DDPAASQEVD LVSKMHKAIT ILQFKLEKEI IDRRPEFELE GRLLLDKIDY EKGTIILNGI
     EYKLNDNNFP TIDPKDPYKL TDEESVLIDK LVYSFVNSDK LQKHVRFLFS KGNMYLKFNS
     NLLFHGCIPL DDEGNLKSMC IQGEEYESKR LLEKFDSLSR EGYFEKVGSE EKTYGMDIMW
     YLWTGPVSPL FGKKQMATFE RYFIDDEIAH IEQKTGYYKL RDREEMCDMI LREFGLDPSE
     SRIINGHVPV KKKNGESPIK ANGKMIVIDG GFSKAYQKQT GIAGYTLIYN SYGLQLVSHE
     HFSSTEESIM KEKDILSTTL VVEQKLKRKT VEDTDIGKDL QVQIKDLKEL LLIYRKGIIK
     EIR
//