ID B2IXJ9_NOSP7 Unreviewed; 3242 AA. AC B2IXJ9; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 02-SEP-2026, entry version 94. DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ACC81527.1}; DE EC=5.1.1.11 {ECO:0000313|EMBL:ACC81527.1}; DE EC=6.2.1.26 {ECO:0000313|EMBL:ACC81527.1}; GN OrderedLocusNames=Npun_R3025 {ECO:0000313|EMBL:ACC81527.1}; OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102). OC Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Nostocales; OC Nostocaceae; Nostoc. OX NCBI_TaxID=63737 {ECO:0000313|EMBL:ACC81527.1, ECO:0000313|Proteomes:UP000001191}; RN [1] {ECO:0000313|Proteomes:UP000001191} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191}; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J., RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.; RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133."; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACC81527.1, ECO:0000313|Proteomes:UP000001191} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191}; RX PubMed=23463784; DOI=10.1104/pp.112.213116; RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.; RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a RT Cyanobacterium-Plant Symbiosis."; RL Plant Physiol. 161:1984-1992(2013). CC -!- COFACTOR: CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942; CC Evidence={ECO:0000256|ARBA:ARBA00001957, ECO:0000256|PROSITE- CC ProRule:PRU00258}; CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family. CC {ECO:0000256|ARBA:ARBA00006432}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001037; ACC81527.1; -; Genomic_DNA. DR RefSeq; WP_012409514.1; NC_010628.1. DR STRING; 63737.Npun_R3025; -. DR EnsemblBacteria; ACC81527; ACC81527; Npun_R3025. DR KEGG; npu:Npun_R3025; -. DR eggNOG; COG1020; Bacteria. DR HOGENOM; CLU_000022_11_0_3; -. DR OrthoDB; 9757538at2; -. DR PhylomeDB; B2IXJ9; -. DR Proteomes; UP000001191; Chromosome. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0008756; F:o-succinylbenzoate-CoA ligase activity; IEA:UniProtKB-EC. DR GO; GO:0047462; F:phenylalanine racemase (ATP-hydrolyzing) activity; IEA:UniProtKB-EC. DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro. DR GO; GO:0043041; P:amino acid activation for nonribosomal peptide biosynthetic process; IEA:TreeGrafter. DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-ARBA. DR GO; GO:0072330; P:monocarboxylic acid biosynthetic process; IEA:UniProtKB-ARBA. DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProtKB-ARBA. DR CDD; cd17652; A_NRPS_CmdD_like; 1. DR CDD; cd17643; A_NRPS_Cytc1-like; 1. DR CDD; cd12117; A_NRPS_Srf_like; 1. DR CDD; cd19543; DCL_NRPS; 1. DR CDD; cd19531; LCL_NRPS-like; 1. DR FunFam; 3.30.300.30:FF:000010; Enterobactin synthetase component F; 3. DR FunFam; 3.40.50.980:FF:000002; Enterobactin synthetase component F; 1. DR FunFam; 1.10.1200.10:FF:000016; Non-ribosomal peptide synthase; 1. DR FunFam; 3.30.559.10:FF:000012; Non-ribosomal peptide synthetase; 1. DR FunFam; 3.40.50.12780:FF:000012; Non-ribosomal peptide synthetase; 3. DR FunFam; 3.40.50.980:FF:000001; Non-ribosomal peptide synthetase; 3. DR FunFam; 2.30.38.10:FF:000001; Non-ribosomal peptide synthetase PvdI; 3. DR FunFam; 1.10.1200.10:FF:000005; Nonribosomal peptide synthetase 1; 2. DR Gene3D; 3.30.300.30; -; 3. DR Gene3D; 3.40.50.980; -; 6. DR Gene3D; 1.10.1200.10; ACP-like; 3. DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3. DR Gene3D; 2.30.38.10; Luciferase, Domain 3; 3. DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3. DR InterPro; IPR010071; AA_adenyl_dom. DR InterPro; IPR036736; ACP-like_sf. DR InterPro; IPR045851; AMP-b_sf. DR InterPro; IPR025110; AMP-bd_C. DR InterPro; IPR020845; AMP-binding_CS. DR InterPro; IPR000873; AMP-dep_synth/lig_dom. DR InterPro; IPR023213; CAT-like_dom_sf. DR InterPro; IPR001242; Condensation_dom. DR InterPro; IPR020806; PKS_PP-bd. DR InterPro; IPR009081; PP-bd_ACP. DR InterPro; IPR006162; Ppantetheine_attach_site. DR NCBIfam; TIGR01733; AA-adenyl-dom; 3. DR NCBIfam; NF003417; PRK04813.1; 3. DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1. DR PANTHER; PTHR45527:SF14; PLIPASTATIN SYNTHASE SUBUNIT B; 1. DR Pfam; PF00501; AMP-binding; 3. DR Pfam; PF13193; AMP-binding_C; 3. DR Pfam; PF00668; Condensation; 3. DR Pfam; PF00550; PP-binding; 3. DR SMART; SM00823; PKS_PP; 3. DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3. DR SUPFAM; SSF47336; ACP-like; 3. DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6. DR PROSITE; PS00455; AMP_BINDING; 3. DR PROSITE; PS50075; CARRIER; 3. DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2. PE 3: Inferred from homology; KW Isomerase {ECO:0000313|EMBL:ACC81527.1}; KW Ligase {ECO:0000313|EMBL:ACC81527.1}; KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450, ECO:0000256|PROSITE- KW ProRule:PRU00258}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000001191}. FT DOMAIN 996..1070 FT /note="Carrier" FT /evidence="ECO:0000259|PROSITE:PS50075" FT DOMAIN 2063..2138 FT /note="Carrier" FT /evidence="ECO:0000259|PROSITE:PS50075" FT DOMAIN 3129..3204 FT /note="Carrier" FT /evidence="ECO:0000259|PROSITE:PS50075" FT MOD_RES 1031 FT /note="O-(pantetheine 4'-phosphoryl)serine" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00258" FT MOD_RES 2098 FT /note="O-(pantetheine 4'-phosphoryl)serine" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00258" FT MOD_RES 3164 FT /note="O-(pantetheine 4'-phosphoryl)serine" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00258" SQ SEQUENCE 3242 AA; 365072 MW; E262C27B72E066CF CRC64; MAVVDKKSNS KNIESIYPLS PMQQGMLFHT LYAPETGVYF QQLVCSLNGQ LNISAFEQAW QRVIERHPVL RTLFLWENRN KPLQVVRQIV NLPWTNYDWR SLSSIEQQEE LENFLQADRD KGFELNQAPL MRCTLIRVAD YTYNFVWSHH HLLLDGWSIP TIIKEIFAFY DAFNEGNNLN LDKPRPYEDY IDWCQKQDIS QAKRFWQLQL KGLTATTPLI VDKPLIKNQE QPSSYATQHA QLTEPATIAL QAFTRQHQLT LNNLVQGAWA ILLSRYSGEV DVIFGATVSG RPPDIVGIES MVGLFINTLP IRVSVPAEIE VLPWLKELQA QQVEREQHSY NQLVEIQSWT EIPKGMPLFE SIVVFENYPI DASEQNNGIN ISNVRSIERT NYPLNLAVIP GRQLSVGISY DSDRFDAATI SRMLGHFQIL LESLAANPHQ HLNELPLLTK TEENQLLSEW NNTQTTYFQE QCIHELFELQ VECSPDAIAI VYEDEQLTYQ ELNNRANQLA HHLRNLGVGA EILVGICVER SIEMLIGILG ILKAGGAYVP LDPNYPQERL SFSLEDSQVK VLITQQQLLS KLPAHQAQVL CIDADWEIIA QQSVQNPQIV TTSANLAYII YTSGSTGKPK GVLINHANVV RLFTATEEWF YFNQQDVWTL FHSFAFDFSV WEIWGALIKG GRLVVVPYWV SRSPADFLKL LDKQKVTVLN QTPSAFRQLI QAEQLIDTPA NLALRWVIFG GEALEIQSLK PWFERHGDKY PQLVNMYGIT ETTVHVTYRP ITIADLSSNT GSVIGCPIPD LQVYVLDKAK QLLPIGVPGE MYVGGASLAR GYLNRVELTS QVFVANPFSD DPNARLYKTG DLARYLENGD LEYLGRIDNQ VKIRGFRIEL GEIEAALTQH PQVQASVVIA RVDTPGDTCT ERSQSKRLVA YLVIHQAQVL TVNDLRQFLD SKLPEYMIPA AFVFLDSLPL TSNGKVDRRA LPVPDTARTE EKAFVAPRTP TEKLLTDIWA QVLGLEQVGI NDNFFALGGD SIRSIQVQSQ SQKQGLSFSL QQLFVHQTIS NLVQELQSVE VSRVIIESEK PFSLISETDR QKLPDEVEDA YPLTMLQMGM LFHSELNEDT AVYHNVSSFH LQAHFNLEKF QTAVEQLVAR HPILRTSIDL SNFSEPLQLV HRQVPIPLQM KDLSHLSVDE QQQKIDAWFE AEKNRKFDWK QSPLLRFQIH CYSPEEFQFS FTEHHAILDG WSVASMLNEL FGNYFSLVNQ KAQPLLPSPS SSFRNFVALE RQALGSKEHE YYWTEKLKEC TITMVPRWYS SQQKAKVRQV GTQDVPLSAD LYNGLQKLAQ FIGVPLKSVL LAAHVRVLSI ISNQVDVLTG LVANGRPEQT DSEQVLGLFL NSLPFRLNLS GGTWVDLIRQ VFDAEVELLP FRRYPLGQLQ RILGGQPLFE IIFNFVHFHV YQTVIELNNN VELLGLKSVE ETNFTLAVNF KLNPGSSELE VGFAYDASEL CREQIKAISS YYVKTLDAMV KEPLESYELC SGLSTQEQYQ LLEEWNDTQR NYLQDICIHQ FFEMQVERTP DAVALVFENQ QLTYRELNQQ ANHLAHYLRT LGVRVDVLVG LCVERSLEML VGLLGILKAG GAYVPIDPEY PQERISHILS DSQVSLLLTQ HRLVARLPEH QATLVVIDES WEQIIQHSQE NPISGVKDSD LVNVIYTSGS TGKPKGVMVK HSGLCNLAQA QIDLFDLLPS SRILQFASFS FDASIWEVVM ALGSGARLYL GTKESLLPGL ELIELLRDYG ITHITLPPSA LAVLPQAELP ALQNIIVAGE ACAPDLIKQW SVGRRFFNAY GPTETTVCAT VAECGNGERS DKPPIGRPIP NTQAYILDSY LQPVPIGVPG ELHIGGAGVA QGYLNRPDLT QEKFIPNPFN NSKFKIQNSK LYKTGDLARY LPDGNIEYLG RIDHQVKIRG FRIELGEIEA ILSQHPAILQ VTVIAREDTP GDKCLVAYLA LNQEPTPTIN ELRQFLGSKL PEYMIPSAFV FLETLPLTPN GKVDRRALPL PETLRELEVN FVAPRTPIEE ILAPIWADVL RVEQIGVYDN FFELGGHSLL ATQLVSRIRT TFKIELPLRS LFEAATIANL AEYIQQYQRN SSELLIPPLQ PVARNENIPL SFAQQRLWFL NQLDPNSAAY NIPGAVSFQG QLNVAALEQS LSEIIRRHEA LRTNFITQAG EAVQIIRPVS SWTMTVIDLQ DLPADEREIE IQQLATVAAQ QPFDLVNESL IRTTLLAISE TENILLFCMH HIVSDGWSMG VFVQEVAELY TAFSQGHLSS LPELAIQYAD FAVWQRQWLQ GEVKESQINY WREQLAGAPA LLELPTDRPR PAVQTFRGTT QSFSLSEELS QALSLLSRQE GVTLFMTLLA AFDTLLHRYT GQTDILVGSA IANRNYSEIE GLIGFFVNTL VFRTDVSGNP SFRQLLERVR EVSLEAHTHQ DLPFELLVEA LQPERDLSHT PLFQVMFVFQ NTPTSDIELP GLTLSSLTTE SLTAKFDLTL AFENTDQGLV GAWEYNTDLF DTLTIARMIG HFQTLLESIV TNPEQPVSQL PLLTVNEQHQ LLNEWNNTQT EYPQNQCIHE LFTAQAERNP DLVAAVFGSQ QITYQELNSR ANQLAHYLRT LGVGTEVLVG IFVERSLEML VGLLGILKAG GAYVPLDPDY PQERLSLMLA DSQVPVLLTQ QRLVEKLPEY GQPVVCLDTG WDIINRESTA NLHSEVTADK LAYVIYTSGS TGKPKGVAVP HRAVNRLVFN TNYIQLDAND CIAQAANASF DAATFEIWGA LLHGARLVGV THNIALSPQE FAAYIREQEI SVLFLTTALF NQLASFVPQA FNTLRYLLFG GEAVDPRWVK EVLQNGAPQH LLHVYGPTES TTFSSWFLIE DVPATATTIP IGQPISNTQI YLLDQNLQPV PIGVPGELYI GGDGLAQGYL NRLELTQEKF IANPFNNSKL YKTGDLGRYL PDGNIEYLAR IDNQVKIRGF RIELGEIETA LLQHPAIREV VVLAREDISD DACGGLCQRR LVAYIIFELN QTHSISDLRS FLQRQLPNYM IPAAFVFLEQ FPLTPNGKID RRSLPAPDLS AQFAASYVAP RSKIEQAIAN IWQEVLQLEK VGIDDNFFDL GGHSLLMVKL TQKLQEFLNQ DISLLEMFKY PTISTLAKYL SSEKTDSASD IEKKNNQITD IKAGRNRLKQ RLARSSKGAN NE //