ID B2IDD4_BEII9 Unreviewed; 407 AA. AC B2IDD4; DT 10-JUN-2008, integrated into UniProtKB/TrEMBL. DT 10-JUN-2008, sequence version 1. DT 04-NOV-2026, entry version 80. DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 1 {ECO:0000256|ARBA:ARBA00039450}; DE EC=2.3.1.41 {ECO:0000256|ARBA:ARBA00013191}; DE AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase I {ECO:0000256|ARBA:ARBA00041620}; DE AltName: Full=Beta-ketoacyl-ACP synthase I {ECO:0000256|ARBA:ARBA00042143}; GN OrderedLocusNames=Bind_0332 {ECO:0000313|EMBL:ACB93986.1}; OS Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB OS 8712). OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria; OC Hyphomicrobiales; Beijerinckiaceae; Beijerinckia. OX NCBI_TaxID=395963 {ECO:0000313|EMBL:ACB93986.1, ECO:0000313|Proteomes:UP000001695}; RN [1] {ECO:0000313|Proteomes:UP000001695} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 9039 / DSM 1715 / NCIMB 8712 RC {ECO:0000313|Proteomes:UP000001695}; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., RA Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F., RA Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N., RA Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.; RT "Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC RT 9039."; RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACB93986.1, ECO:0000313|Proteomes:UP000001695} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 9039 / DSM 1715 / NCIMB 8712 RC {ECO:0000313|Proteomes:UP000001695}; RX PubMed=20601475; DOI=10.1128/JB.00656-10; RA Tamas I., Dedysh S.N., Liesack W., Stott M.B., Alam M., Murrell J.C., RA Dunfield P.F.; RT "Complete genome sequence of Beijerinckia indica subsp. indica."; RL J. Bacteriol. 192:4532-4533(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=(3Z)-decenoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxo-(5Z)- CC dodecenoyl-[ACP] + holo-[ACP] + CO2; Xref=Rhea:RHEA:54940, Rhea:RHEA- CC COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9927, Rhea:RHEA- CC COMP:14042, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, CC ChEBI:CHEBI:78449, ChEBI:CHEBI:78798, ChEBI:CHEBI:138410; CC Evidence={ECO:0000256|ARBA:ARBA00048121}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54941; CC Evidence={ECO:0000256|ARBA:ARBA00048121}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] CC + holo-[ACP] + CO2; Xref=Rhea:RHEA:22836, Rhea:RHEA-COMP:9623, CC Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:14125, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, CC ChEBI:CHEBI:78449, ChEBI:CHEBI:78776, ChEBI:CHEBI:138651; CC EC=2.3.1.41; Evidence={ECO:0000256|ARBA:ARBA00048506}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22837; CC Evidence={ECO:0000256|ARBA:ARBA00048506}; CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP CC synthases family. {ECO:0000256|ARBA:ARBA00008467, CC ECO:0000256|RuleBase:RU003694}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001016; ACB93986.1; -; Genomic_DNA. DR RefSeq; WP_012383344.1; NC_010581.1. DR AlphaFoldDB; B2IDD4; -. DR STRING; 395963.Bind_0332; -. DR KEGG; bid:Bind_0332; -. DR eggNOG; COG0304; Bacteria. DR HOGENOM; CLU_000022_69_2_5; -. DR OMA; AAEMIQW; -. DR OrthoDB; 9808669at2; -. DR Proteomes; UP000001695; Chromosome. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro. DR CDD; cd00834; KAS_I_II; 1. DR FunFam; 3.40.47.10:FF:000006; 3-oxoacyl-[acyl-carrier-protein] synthase I; 1. DR Gene3D; 3.40.47.10; -; 2. DR InterPro; IPR000794; Beta-ketoacyl_synthase. DR InterPro; IPR014031; KAS_C. DR InterPro; IPR014030; KAS_N. DR InterPro; IPR018201; Ketoacyl_synth_AS. DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom. DR InterPro; IPR016039; Thiolase-like. DR NCBIfam; NF005935; fabB; 1. DR NCBIfam; NF005589; PRK07314.1; 1. DR PANTHER; PTHR11712:SF306; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1; 1. DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1. DR Pfam; PF00109; ketoacyl-synt; 1. DR Pfam; PF02801; Ketoacyl-synt_C; 1. DR SMART; SM00825; PKS_KS; 1. DR SUPFAM; SSF53901; Thiolase-like; 2. DR PROSITE; PS00606; KS3_1; 1. DR PROSITE; PS52004; KS3_2; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Reference proteome {ECO:0000313|Proteomes:UP000001695}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003694}. FT DOMAIN 1..404 FT /note="Ketosynthase family 3 (KS3)" FT /evidence="ECO:0000259|PROSITE:PS52004" FT ACT_SITE 161 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10022" SQ SEQUENCE 407 AA; 43174 MW; 321CDB9ADDFD3A70 CRC64; MRRVVVTGMG IVSSIGNTSQ EVLASLREAK SGIVRAERYA ELGFRSQVHG APTLDPSAML DRRAMRFHAG GTAWNHVAMD QAILDAGLEP SDVSNPRTGI IMGSGGPSTR TIVESADITR DKGPKKVGPF AVPKAMSSTA SATLATWFKI KGVNYSISSA CATSNHCIGN AYEMIRYGKQ DVMFAGGCEE LDWTLSVLFD AMGAMAAAYN DRPAVASRAY DKNRDGFVIA GGAGVLVLED LERAKARGAK IYGEIVGYGL TSDGHDMVAP SGEGAVRCMR MALEDVNIPI DYINPHATST GVGDLKEIEA IREVFGAGDK SPPIAATKSL TGHSLGATGV QEAIYSLLMM QNGFICESAN IEELDPAFAD MDIVRHRRDN VSLRAVLSNS FGFGGTNATL VFKHVDA //