ID B1WAR7_XENTR Unreviewed; 915 AA. AC B1WAR7; DT 20-MAY-2008, integrated into UniProtKB/TrEMBL. DT 20-MAY-2008, sequence version 1. DT 02-SEP-2026, entry version 103. DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324, ECO:0000256|PROSITE-ProRule:PRU01084}; DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324, ECO:0000256|PROSITE-ProRule:PRU01084}; GN Name=hk2 {ECO:0000313|Xenbase:XB-GENE-5817381}; GN Synonyms=LOC100145699 {ECO:0000313|EMBL:AAI61474.1}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61474.1}; RN [1] {ECO:0000313|EMBL:AAI61474.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole embryo {ECO:0000313|EMBL:AAI61474.1}; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+); CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00048160}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; CC Evidence={ECO:0000256|ARBA:ARBA00048160}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+); CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:229467, ChEBI:CHEBI:456216; CC EC=2.7.1.1; Evidence={ECO:0000256|ARBA:ARBA00044613}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; CC Evidence={ECO:0000256|ARBA:ARBA00044613}; CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|ARBA:ARBA00004888}. CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism. CC {ECO:0000256|ARBA:ARBA00005028}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|PROSITE-ProRule:PRU01084}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01084}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC161474; AAI61474.1; -; mRNA. DR RefSeq; NP_001120545.1; NM_001127073.1. DR AlphaFoldDB; B1WAR7; -. DR GeneID; 100145699; -. DR KEGG; xtr:100145699; -. DR AGR; Xenbase:XB-GENE-5817381; -. DR CTD; 3099; -. DR Xenbase; XB-GENE-5817381; hk2. DR HOGENOM; CLU_014393_1_0_1; -. DR OMA; CFETKHV; -. DR OrthoDB; 419537at2759; -. DR UniPathway; UPA00109; UER00180. DR UniPathway; UPA00242; -. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0005536; F:D-glucose binding; IEA:InterPro. DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC. DR GO; GO:0051156; P:glucose 6-phosphate metabolic process; IBA:GO_Central. DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central. DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central. DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro. DR FunFam; 3.40.367.20:FF:000001; Hexokinase 1; 1. DR FunFam; 3.30.420.40:FF:000494; Hexokinase 2; 1. DR FunFam; 3.40.367.20:FF:000020; Hexokinase-1; 1. DR FunFam; 3.30.420.40:FF:000095; Phosphotransferase; 1. DR Gene3D; 3.30.420.40; -; 2. DR Gene3D; 3.40.367.20; -; 2. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; HEXOKINASE; 1. DR PANTHER; PTHR19443:SF86; HEXOKINASE; 1. DR Pfam; PF00349; Hexokinase_1; 2. DR Pfam; PF03727; Hexokinase_2; 2. DR PRINTS; PR00475; HEXOKINASE. DR SUPFAM; SSF53067; Actin-like ATPase domain; 4. DR PROSITE; PS00378; HEXOKINASE_1; 2. DR PROSITE; PS51748; HEXOKINASE_2; 2. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU01084}; KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|PROSITE- KW ProRule:PRU01084}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE- KW ProRule:PRU01084}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU01084}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE- KW ProRule:PRU01084}. FT DOMAIN 20..215 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 222..455 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" FT DOMAIN 465..663 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 669..903 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" SQ SEQUENCE 915 AA; 100349 MW; 7AE4E512DA1D2E6F CRC64; MVNPRGDETH DNHQVKCNQI ECCLQPFHLS QVQLLSVRDL MLANMERGLM KTPQKPSTLK MLPTYVRSTP DGTERGDFLV LDLGGAQFRI LHVELKDSAK VEMESQVYAI PDEVMHGTGQ QLFDHVAECL GRFLRQQKLH QKVLPLGFTF SFPCVQSQLD KSVLISWTKG FHCSDVEGKD VVHLLREAIC RQGDYEVDVI AIVNDTVGAM MSCGYQDHSC EVGFIVGTGT NLCYMEEMGN VESVEGDEGK MCINTEWGAL GDDGELSSIQ TEIDKQLDQN SLVSGKQCFD KLVSGMYMGE IVRLILVKLA NQGLLFDGTT TQALLSKGCF ETKHVSAIED DHSGLSSARK ILSVLGLNPS EQDCVNVQQV CSAVSTRSAN LCAAGLAAVA ARLQCNSQDP NRKITIGVDG SVYKQHPKFS QRLHSALQHL APKCQINFLI SEDGSGKGTA IVTAVAKRLA AQRHQIDEIL APFQLSQAKL EEVQSRMRTE MAIGLCKDTH ASATVKMLPT YVRSTPDGTE RGDFIALDLG GTNFRVLYVH IGRREDVGVQ IVSKTYSLPQ EIIQGTGVKL FDHIIDCISE FQSENNLRGR RLPLGFTFSF PCKQTNLDQG ILMTWTKGFS ASGCVGKDVV MLLREAAVRK KNNDLIVVAL VNDTVGTMMT CGYSDPACEI GLIVGTGTNA CYMEELRNVE LLDGDEGKMC VNMEWGAFGD NNCLEDIATS FDRDVDKFSI NPGKQRYEKM ISGMYLGEIV RQILIILTQR KILFGGNISE RLKTRDIFPT RFLSLIESDT LGLVQVRSIL TDLGLRSTCD DTMLVKEVCT VVSRRAAQLC AAGIAAVVEK MRENRGLEQL KVTVGVDGTL YKLHPHFAGV VHETVKVLAP RCDVTFLQSD DGSGKGAALI TAVACRIAGA EARAA //