ID   B1MLJ1_MYCA9            Unreviewed;       544 AA.
AC   B1MLJ1;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   02-SEP-2026, entry version 102.
DE   RecName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00032259};
DE            EC=1.2.1.88 {ECO:0000256|ARBA:ARBA00012884};
DE   AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00032259};
GN   OrderedLocusNames=MAB_1330 {ECO:0000313|EMBL:CAM61418.1};
OS   Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP
OS   104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948) (Mycobacterium
OS   abscessus).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Mycobacteriaceae; Mycobacteroides; Mycobacteroides abscessus.
OX   NCBI_TaxID=561007 {ECO:0000313|EMBL:CAM61418.1, ECO:0000313|Proteomes:UP000007137};
RN   [1] {ECO:0000313|EMBL:CAM61418.1, ECO:0000313|Proteomes:UP000007137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19977 / DSM 44196 / CCUG 20993 / CIP 104536 / JCM 13569 /
RC   NCTC 13031 / TMC 1543 / L948 {ECO:0000313|Proteomes:UP000007137};
RX   PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA   Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA   Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA   Gaillard J.L.;
RT   "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT   Mycobacterium abscessus.";
RL   PLoS ONE 4:E5660-E5660(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH
CC         + 2 H(+); Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58066; EC=1.2.1.88;
CC         Evidence={ECO:0000256|ARBA:ARBA00048142};
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004786}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986}.
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DR   EMBL; CU458896; CAM61418.1; -; Genomic_DNA.
DR   RefSeq; WP_005092981.1; NC_010397.1.
DR   AlphaFoldDB; B1MLJ1; -.
DR   GeneID; 93378276; -.
DR   KEGG; mab:MAB_1330; -.
DR   UniPathway; UPA00261; UER00374.
DR   Proteomes; UP000007137; Chromosome.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0003842; F:L-glutamate gamma-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-ARBA.
DR   CDD; cd07123; ALDH_F4-17_P5CDH; 1.
DR   FunFam; 3.40.605.10:FF:000006; 1-pyrroline-5-carboxylate dehydrogenase; 1.
DR   FunFam; 3.40.309.10:FF:000005; 1-pyrroline-5-carboxylate dehydrogenase 1; 1.
DR   Gene3D; 3.40.605.10; Aldehyde Dehydrogenase, Chain A, domain 1; 1.
DR   Gene3D; 3.40.309.10; Aldehyde Dehydrogenase, Chain A, domain 2; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR005931; P5CDH/ALDH4A1.
DR   InterPro; IPR050485; Proline_metab_enzyme.
DR   NCBIfam; TIGR01236; D1pyr5carbox1; 1.
DR   PANTHER; PTHR42862; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR42862:SF1; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Proline metabolism {ECO:0000256|ARBA:ARBA00023062};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007137}.
FT   DOMAIN          53..514
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        327
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10008"
SQ   SEQUENCE   544 AA;  58681 MW;  8B635A2095103486 CRC64;
     MDAITTVPAP SNEPVLTYAP NTPERDRLTT ALGELTASPI DLPHVIGGAR RMSDGERIDV
     VQPHNHRSVL GTVTNAGHRE AHDAVEAAIA AKNYWATLPF DDRAAVFLRA ADLLSGPWRA
     ILNAATMLGQ SKTAYQAEID SACELADFWR FNVQFARQIL AEQPNSGGGA WNRLEYRPLE
     GFVYAITPFN FTAIAGNLPT APALLGNTVV WKPSVTQAFA AHFTLELLEA AGLPPGVINL
     LNGDGIAVSD VALADPRLAG IHFTGSTRTF QHLWRQVGTN IDRYNTYPRL VGETGGKDFV
     VAHASARPEI LRTALIRGAF DYQGQKCSAA SRAFVPRSVW DQMGDEFLDA TSGLSYGDVT
     DLSNFGGAVI DEKSFARNAA AIDRAKSAGV TIAAGGEYDD SQGYFVRPTV LLSDDPTDEA
     FSTEYFGPIL AVHVYPDDDY GRILDVVDTG SPYGLTGAVI ADDRAAIRQA SDRLRYAAGN
     FYVNDKPTGA VVGQQPFGGG RASGTDDKAG SPLNLQRWLL PRSIKETFNA PTEYQYPHME
     REDG
//