ID   B1AV75_MOUSE            Unreviewed;       210 AA.
AC   B1AV75;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   02-SEP-2026, entry version 102.
DE   RecName: Full=Cilia- and flagella-associated protein 418 {ECO:0000256|ARBA:ARBA00026215};
GN   Name=Cfap418 {ECO:0000313|Ensembl:ENSMUSP00000103966.2,
GN   ECO:0000313|MGI:MGI:1914407};
GN   Synonyms=2610301B20Rik {ECO:0000313|MGI:MGI:1914407};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000103966.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000103966.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103966.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000103966.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103966.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000103966.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103966.2};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- FUNCTION: May be involved in photoreceptor outer segment disk
CC       morphogenesis. {ECO:0000256|ARBA:ARBA00024819}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Photoreceptor inner segment {ECO:0000256|ARBA:ARBA00004437}.
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DR   AlphaFoldDB; B1AV75; -.
DR   SMR; B1AV75; -.
DR   PeptideAtlas; B1AV75; -.
DR   ProteomicsDB; 307823; -.
DR   Antibodypedia; 12959; 40 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000101504.3; ENSMUSP00000103966.2; ENSMUSG00000059482.16.
DR   AGR; MGI:1914407; -.
DR   MGI; MGI:1914407; Cfap418.
DR   VEuPathDB; HostDB:ENSMUSG00000059482; -.
DR   GeneTree; ENSGT00390000006173; -.
DR   OMA; AHGKRCC; -.
DR   OrthoDB; 259905at2759; -.
DR   PhylomeDB; B1AV75; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000059482; Expressed in spermatocyte and 240 other cell types or tissues.
DR   ExpressionAtlas; B1AV75; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029239; CFAP418.
DR   PANTHER; PTHR33958:SF1; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 418; 1.
DR   PANTHER; PTHR33958; PROTEIN C8ORF37; 1.
DR   Pfam; PF14996; RMP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B1AV75,
KW   ECO:0007829|ProteomicsDB:B1AV75};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   REGION          24..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   210 AA;  23935 MW;  A2B0CB98B790AF23 CRC64;
     MAKDLDELLD EVETKFCRLD PLRLDLGERP KGDGGGGSHS GDRNGAQEKE TLRSTETFKK
     EDDLDSLINE IFEEPDFDRK SFQKFKSKSS SNTCVRAPMQ GVSKSCSPVY LSGSAIPCGI
     GTNTSQRACD RLRCVACDFR IVSYNDYMWD KSCDYLFFSR NNMPEFHKLK TKLIEKKGAR
     AYACQCSWRT VEELTDLQTD HQLRWVCGKH
//