ID   B1ATE0_MOUSE            Unreviewed;       422 AA.
AC   B1ATE0;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   04-NOV-2026, entry version 111.
DE   SubName: Full=N-sulfoglucosamine sulfohydrolase (sulfamidase) {ECO:0000313|Ensembl:ENSMUSP00000097748.3};
GN   Name=Sgsh {ECO:0000313|Ensembl:ENSMUSP00000097748.3,
GN   ECO:0000313|MGI:MGI:1350341};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097748.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000097748.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097748.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000097748.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097748.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000097748.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097748.3};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; B1ATE0; -.
DR   SMR; B1ATE0; -.
DR   PeptideAtlas; B1ATE0; -.
DR   ProteomicsDB; 315943; -.
DR   Antibodypedia; 19766; 276 antibodies from 35 providers.
DR   Ensembl; ENSMUST00000100172.4; ENSMUSP00000097748.3; ENSMUSG00000005043.15.
DR   AGR; MGI:1350341; -.
DR   MGI; MGI:1350341; Sgsh.
DR   VEuPathDB; HostDB:ENSMUSG00000005043; -.
DR   GeneTree; ENSGT00390000013080; -.
DR   HOGENOM; CLU_650466_0_0_1; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000005043; Expressed in stroma of bone marrow and 168 other cell types or tissues.
DR   ExpressionAtlas; B1ATE0; baseline and differential.
DR   FunFam; 3.40.720.10:FF:000150; N-sulfoglucosamine sulfohydrolase (sulfamidase); 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43108:SF6; N-SULPHOGLUCOSAMINE SULPHOHYDROLASE; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B1ATE0,
KW   ECO:0007829|ProteomicsDB:B1ATE0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..422
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002761932"
FT   DOMAIN          23..248
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          335..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   422 AA;  46311 MW;  E01F5706346C16B0 CRC64;
     MHCPGLACCT ILLVLGLCGA HSRNVLLIVA DDGGFESGVY NNTAIATPHL DALSRHSLIF
     RNAFTSVSSC SPSRASLLTG LPQHQNGMYG LHQDVHHFNS FDKVQSLPLL LNQAGVRTGI
     IGKKHVGPET VYPFDFAFTE ENSSVMQVGR NITRIKQLVQ KFLQTQDDRP FFLYVAFHDP
     HRCGHSQPQY GTFCEKFGNG ESGMGYIPDW TPQIYDPQDV MVPYFVPDTP AARADLAAQY
     TTIGRMDQER QDQPVLARYS RAFAGVISRA PTALGPGQRR LREPSRPHPY HPGLVLHPVP
     QLCHLWLKDD PAHRPIPPAG AGGRAPLGHC LQQPEPPRGH HVLPDALGVP PELPPHSQPE
     LQDAISHRPR FLCLADLPGP PEPNHHRPAH GLVQGPPPLL LPGTLGTLRH QPGPSRDTEP
     GR
//