ID   B1AS25_MOUSE            Unreviewed;       171 AA.
AC   B1AS25;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   04-NOV-2026, entry version 113.
DE   SubName: Full=Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta {ECO:0000313|Ensembl:ENSMUSP00000119858.2};
DE   Flags: Fragment;
GN   Name=Pik3cd {ECO:0000313|Ensembl:ENSMUSP00000119858.2,
GN   ECO:0000313|MGI:MGI:1098211};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119858.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000119858.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119858.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000119858.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119858.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000119858.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119858.2};
RG   Ensembl;
RL   Submitted (JUL-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00877}.
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DR   AlphaFoldDB; B1AS25; -.
DR   SMR; B1AS25; -.
DR   PeptideAtlas; B1AS25; -.
DR   ProteomicsDB; 306648; -.
DR   Antibodypedia; 4215; 633 antibodies from 43 providers.
DR   Ensembl; ENSMUST00000127273.8; ENSMUSP00000119858.2; ENSMUSG00000039936.20.
DR   AGR; MGI:1098211; -.
DR   MGI; MGI:1098211; Pik3cd.
DR   VEuPathDB; HostDB:ENSMUSG00000039936; -.
DR   GeneTree; ENSGT00940000159079; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000039936; Expressed in granulocyte and 170 other cell types or tissues.
DR   ExpressionAtlas; B1AS25; baseline and differential.
DR   Gene3D; 3.10.20.770; -; 1.
DR   InterPro; IPR003113; PI3K_ABD.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF02192; PI3K_p85B; 1.
DR   SMART; SM00143; PI3K_p85B; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS51544; PI3K_ABD; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B1AS25,
KW   ECO:0007829|ProteomicsDB:B1AS25};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          16..105
FT                   /note="PI3K-ABD"
FT                   /evidence="ECO:0000259|PROSITE:PS51544"
FT   NON_TER         171
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000119858.2"
SQ   SEQUENCE   171 AA;  20011 MW;  120DB379934E65E5 CRC64;
     MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH
     MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREGDRVK KLINSQISLL
     IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPLQ L
//