ID B1APH0_HUMAN Unreviewed; 1032 AA. AC B1APH0; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 02-SEP-2026, entry version 124. DE SubName: Full=Basonuclin zinc finger protein 2 {ECO:0000313|Ensembl:ENSP00000370042.1}; GN Name=BNC2 {ECO:0000313|Ensembl:ENSP00000370042.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000370042.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000370042.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11237011; DOI=10.1038/35057062; RG International Human Genome Sequencing Consortium; RA Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., RA Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., RA Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., RA McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J., RA Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., RA Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., RA Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., RA Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., RA Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., RA Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., RA Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., RA Waterston R.H., Wilson R.K., Hillier L.W., McPherson J.D., Marra M.A., RA Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R., RA Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A., RA Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W., RA Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., RA Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E., RA Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B., RA Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L., RA Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y., RA Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., RA Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., RA Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., RA Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M., RA Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., RA Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., RA Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M., RA Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R., RA Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A., RA Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J., RA Lehrach H., Reinhardt R., McCombie W.R., de la Bastide M., Dedhia N., RA Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., RA Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G., RA Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R., RA Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G., RA Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., RA Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J., RA Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M., RA McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J., RA Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E., RA Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., RA Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F., RA Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A., RA Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K., RA Shizuya H., Choi S., Chen Y.J.; RT "Initial sequencing and analysis of the human genome."; RL Nature 409:860-921(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000370042.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [3] {ECO:0000313|Ensembl:ENSP00000370042.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496913; DOI=10.1038/nature03001; RG International Human Genome Sequencing Consortium; RT "Finishing the euchromatic sequence of the human genome."; RL Nature 431:931-945(2004). RN [4] {ECO:0007829|PubMed:20068231} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [5] {ECO:0007829|PubMed:28112733} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). RN [6] {ECO:0000313|Ensembl:ENSP00000370042.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2026) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL162418; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL449983; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL450003; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL450105; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; B1APH0; -. DR MassIVE; B1APH0; -. DR ProteomicsDB; 3297; -. DR Antibodypedia; 10169; 78 antibodies from 17 providers. DR Ensembl; ENST00000380667.6; ENSP00000370042.1; ENSG00000173068.20. DR UCSC; uc064sgd.1; human. DR HGNC; HGNC:30988; BNC2. DR VEuPathDB; HostDB:ENSG00000173068; -. DR GeneTree; ENSGT00390000005844; -. DR HOGENOM; CLU_010637_0_0_1; -. DR OrthoDB; 10070972at2759; -. DR ChiTaRS; BNC2; human. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000173068; Expressed in germinal epithelium of ovary and 164 other cell types or tissues. DR ExpressionAtlas; B1APH0; baseline and differential. DR GO; GO:0001650; C:fibrillar center; IDA:HPA. DR GO; GO:0016604; C:nuclear body; IDA:HPA. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3. DR InterPro; IPR063458; Basonuclin_N. DR InterPro; IPR040436; Disconnected-like. DR InterPro; IPR063606; Znf_C2H2_Disco/BNC. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR15021; DISCONNECTED-RELATED; 1. DR PANTHER; PTHR15021:SF2; ZINC FINGER PROTEIN BASONUCLIN-2; 1. DR Pfam; PF31013; Basonuclin_N; 1. DR Pfam; PF00096; zf-C2H2; 1. DR Pfam; PF12874; zf-met; 1. DR Pfam; PF30355; zf_C2H2-Disco; 3. DR SMART; SM00355; ZnF_C2H2; 6. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|PeptideAtlas:B1APH0, KW ECO:0007829|ProteomicsDB:B1APH0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00042}. FT DOMAIN 374..402 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 766..794 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 968..996 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT REGION 290..318 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 330..356 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 555..574 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 581..675 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 862..881 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 901..941 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1012..1032 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 294..305 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 308..318 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 581..594 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 603..613 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 652..675 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 915..928 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1032 AA; 114535 MW; C832BA74C92CAFEE CRC64; MAHLGPTPPP HSLNYKSEDR LSEQDWPAYF KVPCCGVDTS QIEAIRCTLV NCTCECFQPG KINLRTCDQC KHGWVAHALD KLSTQHLYHP TQVEIVQSNV VFDISSLMLY GTQAVPVRLK ILLDRLFSVL KQEEVLHILH GLGWTLRDYV RGYILQDAAG KVLDRWAIMS REEEIITLQQ FLRFGETKSI VELMAIQEKE GQAVAVPSSK TDSDIRTFIE SNNRTRSPSL LAHLENSNPS SIHHFENIPN SLAFLLPFQY INPVSAPLLG LPPNGLLLEQ PGLRLREPSL STQNEYNESS ESEVSPTPYK NDQTPNRNAL TSITNVEPKT EPACVSPIQN SAPVSDLTKT EHPKSSFRIH RMRRMGSASR KGRVFCNACG KTFYDKGTLK IHYNAVHLKI KHRCTIEGCN MVFSSLRSRN RHSANPNPRL HMPMLRNNRD KDLIRATSGA ATPVIASTKS NLALTSPGRP PMGFTTPPLD PVLQNPLPSQ LVFSGLKTVQ PVPPFYRSLL TPGEMVSPPT SLPTSPIIPT SGTIEQHPPP PSEPVVPAVM MATHEPSADL APKKKPRKSS MPVKIEKEII DTADEFDDED DDPNDGGAVV NDMSHDNHCH SQEEMSPGMS VKDFSKHNRT RCISRTEIRR ADSMTSEDQE PERDYENESE SSEPKLGEES MEGDEHIHSE VSEKVLMNSE RPDENHSEPS HQDVIKVKEE FTDPTYDMFY MSQYGLYNGG GASMAALHES FTSSLNYGSP QKFSPEGDLC SSPDPKICYV CKKSFKSSYS VKLHYRNVHL KEMHVCTVAG CNAAFPSRRS RDRHSANINL HRKLLTKELD DMGLDSSQPS LSKDLRDEFL VKIYGAQHPM GLDVREDASS PAGTEDSHLN GYGRGMAEDY MVLDLSTTSS LQSSSSIHSS RESDAGSDEG ILLDDIDGAS DSGESAHKAE APALPGSLGA EVSGSLMFSS LSGSNGGIMC NICHKMYSNK GTLRVHYKTV HLREMHKCKV PGCNMMFSSV RSRNRHSQNP NLHKNIPFTS VD //