ID   B0WES9_CULQU            Unreviewed;      1209 AA.
AC   B0WES9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   02-SEP-2026, entry version 86.
DE   SubName: Full=Dihydropyridine-sensitive l-type calcium channel {ECO:0000313|EnsemblMetazoa:CPIJ005664-PA};
GN   Name=6037287 {ECO:0000313|EnsemblMetazoa:CPIJ005664-PA};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176 {ECO:0000313|EnsemblMetazoa:CPIJ005664-PA, ECO:0000313|Proteomes:UP000002320};
RN   [1] {ECO:0000313|EnsemblMetazoa:CPIJ005664-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ005664-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   AlphaFoldDB; B0WES9; -.
DR   STRING; 7176.B0WES9; -.
DR   EnsemblMetazoa; CPIJ005664-RA; CPIJ005664-PA; CPIJ005664.
DR   KEGG; cqu:CpipJ_CPIJ005664; -.
DR   VEuPathDB; VectorBase:CPIJ005664; -.
DR   VEuPathDB; VectorBase:CQUJHB017057; -.
DR   eggNOG; KOG2353; Eukaryota.
DR   HOGENOM; CLU_004660_1_1_1; -.
DR   OMA; EIHRIHA; -.
DR   OrthoDB; 10054666at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:TreeGrafter.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:TreeGrafter.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   FunFam; 3.40.50.410:FF:000007; Calcium voltage-gated channel auxiliary subunit alpha2delta 3; 1.
DR   FunFam; 3.30.450.20:FF:000057; Voltage-dependent calcium channel subunit alpha-2/delta-4; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR051173; Ca_channel_alpha-2/delta.
DR   InterPro; IPR063621; Cacna2d1-4/CACHD1_middle.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166:SF63; STRAIGHTJACKET, ISOFORM C; 1.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   Pfam; PF30670; CACHD1_middle; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        1007..1031
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          235..417
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   1209 AA;  138672 MW;  F6332F86823F3C8B CRC64;
     MDAIVEAGDE FVQGWAEKLG AELASLGDFI TRRKDVEDSF KQAQVVSKNG QKIVEEMAKD
     LKYMMDAKVS AVKRIMDTAE NTAISYDEEP VNQSFQYYNA KEMIEPGEII TTPIPMIDED
     PADITTPIPP KEIVLTKKKH FFNEAVNTSV SSVHVPTNVY DRATEVIRAI KWSEALDSIF
     YNNYIGDPTL TWQYFGSSTG FLRQFPATKW EEDPVDLYDC RLRSWYIEAA NSPKDVIILV
     DSSGSMTGQR KDIAKHVVSN ILDTLGPNDY VNIFSFSEEV TEVVECFSET LVQANMGNIR
     ELKLGMDHIK TTEIANVSAA LTKAFELLET FRESRNGARC NQAIMLVSDG VPYSFDEIFS
     EYNWKELPFI PVRVFTYLIG REVADVKEIK EMACKNQGYY VHLSTLAEVR EEVLNYIPVI
     ARPLVLNKRE HPVVWSEVYA DVEDPKMTDW LWEIKERAEQ KERFIDYRKN RVIFFSPEEQ
     HRRMIMKQRM NQDPYSNTQK YNFMTTVSMP VFDRRENATR VANILGVAGA DVPISEIKKY
     LKPHLLGVNG YAFIVTNNGY ILTHPDFRPV FQDILKPAYN TVDMIEVELT DDDRGPRDFN
     PALLHIRESI INQSTGAKWV HVKYHFDEMK RVSRTRRQYY WTPIKNTPFT LVVTYPETYG
     VNRLQIRTED EIHRIHAKSG NVASFFTGIN WRIHPDWVYC KYLNEHANET FATPELELKH
     FLERMKQGGW RWPALRTPPP PEHAMFCDRN LMQALVYDAK VTEWFSRNTS GGSGNKDEKQ
     GNEFKQRFGI TVSFLATHSG LTRWQDHMNF GDESKQAEPD FSETNNRATD EIWYKRAVEL
     YYNIKNRKGA DGSGKDDGDK NSYVYSVPFD AGNRNDTLVT ASNAIFHTDG GKETPVAVVG
     FQFHHSAMYT LFRNITSQCL HSDPQCEKTC FTGDYQCYVI DNNGFVVISE QLQETGSFFG
     EVKPAFMQRL IDDGIFKNVT IYDYQAVCFA GKGTVSLGNV IQTPLRIIWW FLTNAISYIL
     WVVVQIFITI VQAYDEVMYD SSAYDAVAEM GDLEDPTAGR YKEPEFNKVL INRTRPEPCD
     HVITLYELNN DLEPSMYKKD AHQCERPYVV LPVPSSNMIL LVLDTLCPLP SSVPTLTTWP
     VQHDYNASLA CHKVHNVELP RRRPLTCINK HANESIIELC GRGTSFGPQL ALTIALSAIL
     LGMWHFRRP
//