ID   RPOB_CAUSK              Reviewed;        1360 AA.
AC   B0SUP7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   04-NOV-2026, entry version 85.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321};
GN   OrderedLocusNames=Caul_0794;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Caulobacterales; Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) +
CC         diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; CP000927; ABZ69925.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0SUP7; -.
DR   SMR; B0SUP7; -.
DR   STRING; 366602.Caul_0794; -.
DR   KEGG; cak:Caul_0794; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_0_5; -.
DR   OMA; AAANLDC; -.
DR   OrthoDB; 9803954at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   FunFam; 3.90.1800.10:FF:000001; DNA-directed RNA polymerase subunit beta; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1100.10; -; 2.
DR   Gene3D; 2.30.150.10; DNA-directed RNA polymerase, beta subunit, external 1 domain; 1.
DR   Gene3D; 2.40.270.10; DNA-directed RNA polymerase, subunit 2, domain 6; 1.
DR   Gene3D; 3.90.1800.10; RNA polymerase alpha subunit dimerisation domain; 1.
DR   Gene3D; 3.90.1110.10; RNA polymerase Rpb2, domain 2; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   NCBIfam; NF001616; rpoB; 1.
DR   NCBIfam; TIGR02013; rpoB; 1.
DR   PANTHER; PTHR20856; DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 2.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   3: Inferred from homology;
KW   DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription;
KW   Transferase.
FT   CHAIN           1..1360
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_1000086364"
SQ   SEQUENCE   1360 AA;  151127 MW;  6A5531F6D601A849 CRC64;
     MAQSFTGKKR IRKSFGRIPE AVQMPNLIEV QRSSYEQFLQ REVRPGVRKD EGIEAVFKSV
     FPIKDFNERA VLEYVSYEFE EPKYDVEECI QRDMTFAAPL KVKLRLIVFE TEEETGARSV
     KDIKEQDVYM GDIPLMTDKG TFIVNGTERV IVSQMHRSPG VFFDHDKGKT HASGKLLFAA
     RVIPYRGSWL DFEFDAKDVV YVRIDRRRKL PATTFLYALG MDGEEILTTF YDVVPFEKRT
     AAGAEGWATP YKPERWRGVK PEFALIDADS GEEVAAAGTK ITARQAKKLA DNGLKTLLLA
     PEALTGRYLA RDAVNFETGE IYAEAGDELD VTSIEALAAQ GFSTIDVLDI DHVTVGAYMR
     NTLRVDKNAV REDALFDIYR VMRPGEPPTV EAAEAMFKSL FFDAERYDLS AVGRVKMNMR
     LELDASDEMR VLRKEDVLAV LKLLVGLRDG RGEIDDIDNL GNRRVRSVGE LLENQYRVGL
     LRMERAIKER MSSVDIDTVM PHDLINAKPA AASVREFFGS SQLSQFMDQT NPLSEITHKR
     RLSALGPGGL TRERAGFEVR DVHPTHYGRI CPIETPEGPN IGLINSLATH ARVNKYGFIE
     SPYRRVADGK PLEEVVYMSA MEESKHVIAQ SNIKVLNGEI VDDLVPGRIN GEPTLLQKEQ
     VDLMDVSPRQ VVSVAAALIP FLENDDANRA LMGSNMQRQA VPLVQSDAPL VGTGMEAVVA
     RDSGAVVIAK RTGVVEQIDG TRIVVRATEE TDAARSGVDI YRLSKFQRSN QSTCINQRPL
     VKVGDKISAG DIIADGPSTE LGELALGRNA LVAFMPWNGY NFEDSILISE RIVRDDVFTS
     IHIEEFEVMA RDTKLGPEEI TRDIPNVGEE ALRNLDEAGI VAIGAEVQPG DILVGKVTPK
     GESPMTPEEK LLRAIFGEKA SDVRDTSLRL PPGVAGTIVD VRVFNRHGVD KDERALAIER
     AEIDRLGKDR DDEFAILNRN ISGRLRELLI GNVALSGPKG LSRGQITAEG LAEVQPGLWW
     QIALEDEKAM GELESLRRLF DENRKRLDRR FEDKVDKLQR GDELPPGVMK MVKVFVAVKR
     KLQPGDKMAG RHGNKGVISR ILPIEDMPFL ADGTHVDVVL NPLGVPSRMN VGQIFETHLG
     WACAGLGKQI TTLLEDWQAG GQKQALIDRL TEIYGPDEEL PETEEELVEL ARNLGKGVPI
     ATPVFDGARI GDIEDHLRMA GLDPSGQSIL YDGQTGEQFK RPVTVGYIYM LKLHHLVDDK
     IHARSIGPYS LVTQQPLGGK AQFGGQRFGE MEVWALEAYG AAYTLQEMLT VKSDDVAGRT
     KVYESIVRGD DTFEAGIPES FNVLVKEMRS LGLNVELENS
//