ID   A9WIN1_CHLAA            Unreviewed;       249 AA.
AC   A9WIN1;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   28-JAN-2026, entry version 81.
DE   RecName: Full=6-phosphogluconolactonase {ECO:0000256|ARBA:ARBA00020337, ECO:0000256|RuleBase:RU365095};
DE            Short=6PGL {ECO:0000256|RuleBase:RU365095};
DE            EC=3.1.1.31 {ECO:0000256|ARBA:ARBA00013198, ECO:0000256|RuleBase:RU365095};
GN   Name=pgl {ECO:0000256|RuleBase:RU365095};
GN   OrderedLocusNames=Caur_2552 {ECO:0000313|EMBL:ABY35758.1};
OS   Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC   Bacteria; Bacillati; Chloroflexota; Chloroflexia; Chloroflexales;
OC   Chloroflexineae; Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=324602 {ECO:0000313|EMBL:ABY35758.1, ECO:0000313|Proteomes:UP000002008};
RN   [1] {ECO:0000313|Proteomes:UP000002008}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29366 / DSM 635 / J-10-fl
RC   {ECO:0000313|Proteomes:UP000002008};
RX   PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA   Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA   Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA   Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT   "Complete genome sequence of the filamentous anoxygenic phototrophic
RT   bacterium Chloroflexus aurantiacus.";
RL   BMC Genomics 12:334-334(2011).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC       {ECO:0000256|ARBA:ARBA00002681, ECO:0000256|RuleBase:RU365095}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00000832,
CC         ECO:0000256|RuleBase:RU365095};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3. {ECO:0000256|ARBA:ARBA00004961, ECO:0000256|RuleBase:RU365095}.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily.
CC       {ECO:0000256|ARBA:ARBA00010662, ECO:0000256|RuleBase:RU365095}.
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DR   EMBL; CP000909; ABY35758.1; -; Genomic_DNA.
DR   RefSeq; WP_012258411.1; NC_010175.1.
DR   AlphaFoldDB; A9WIN1; -.
DR   FunCoup; A9WIN1; 272.
DR   STRING; 324602.Caur_2552; -.
DR   EnsemblBacteria; ABY35758; ABY35758; Caur_2552.
DR   KEGG; cau:Caur_2552; -.
DR   PATRIC; fig|324602.8.peg.2875; -.
DR   eggNOG; COG0363; Bacteria.
DR   HOGENOM; CLU_053947_2_0_0; -.
DR   InParanoid; A9WIN1; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000002008; Chromosome.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   FunFam; 3.40.50.1360:FF:000005; 6-phosphogluconolactonase; 1.
DR   Gene3D; 3.40.50.1360; -; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR039104; 6PGL.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   NCBIfam; TIGR01198; pgl; 1.
DR   PANTHER; PTHR11054; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   PANTHER; PTHR11054:SF0; 6-PHOSPHOGLUCONOLACTONASE; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365095};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002008}.
FT   DOMAIN          12..237
FT                   /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01182"
SQ   SEQUENCE   249 AA;  26927 MW;  41E277602FBDD85F CRC64;
     MNEQQSIRVY EHADELYRMA ATFVAEQIRS AIDNRGQALI ALSGGSLTSR LYPLLANAPL
     REQIDWSRVS IVFADERYVP FDDSENNYRA TRQTFLDHVP VHADQVFPVP TYYRDPQQAA
     TIYQQQLTAL LTAHGGQIDV ALLGMGPDGH TASLFPRHPV LTAIPAGALT VVVADAPKPP
     PLRLSLTPAA LNTARAVVFV VSGADKAAAV AAALADTGDA MAQPTRLINP VAGTVYWMLD
     RAAAERVTQ
//