ID   ASTD_SALAR              Reviewed;         492 AA.
AC   A9MFG0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   04-NOV-2026, entry version 98.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01174};
DE            EC=1.2.1.71 {ECO:0000255|HAMAP-Rule:MF_01174};
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01174};
DE            Short=SGSD {ECO:0000255|HAMAP-Rule:MF_01174};
GN   Name=astD {ECO:0000255|HAMAP-Rule:MF_01174};
GN   OrderedLocusNames=SARI_01674;
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate
CC       semialdehyde into succinylglutamate. {ECO:0000255|HAMAP-Rule:MF_01174}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H2O = N-
CC         succinyl-L-glutamate + NADH + 2 H(+); Xref=Rhea:RHEA:10812,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58520, ChEBI:CHEBI:58763; EC=1.2.1.71;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01174};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC       {ECO:0000255|HAMAP-Rule:MF_01174}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01174}.
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DR   EMBL; CP000880; ABX21565.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9MFG0; -.
DR   SMR; A9MFG0; -.
DR   STRING; 41514.SARI_01674; -.
DR   KEGG; ses:SARI_01674; -.
DR   HOGENOM; CLU_005391_1_0_6; -.
DR   OMA; AAFYHWS; -.
DR   UniPathway; UPA00185; UER00282.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006527; P:L-arginine catabolic process; IEA:InterPro.
DR   CDD; cd07095; ALDH_SGSD_AstD; 1.
DR   FunFam; 3.40.309.10:FF:000013; N-succinylglutamate 5-semialdehyde dehydrogenase; 1.
DR   FunFam; 3.40.605.10:FF:000010; N-succinylglutamate 5-semialdehyde dehydrogenase; 1.
DR   Gene3D; 3.40.605.10; Aldehyde Dehydrogenase, Chain A, domain 1; 1.
DR   Gene3D; 3.40.309.10; Aldehyde Dehydrogenase, Chain A, domain 2; 1.
DR   HAMAP; MF_01174; Aldedh_AstD; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   NCBIfam; TIGR03240; arg_catab_astD; 1.
DR   NCBIfam; NF006992; PRK09457.1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..492
FT                   /note="N-succinylglutamate 5-semialdehyde dehydrogenase"
FT                   /id="PRO_1000085404"
FT   ACT_SITE        243
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
FT   ACT_SITE        277
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
FT   BINDING         220..225
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01174"
SQ   SEQUENCE   492 AA;  53001 MW;  98C7F8A8930D5A00 CRC64;
     MTLWINGDWI TGQGERRSKT NPVSAEILWQ GNDADTAQVA GACEAARAAF PCWARQPFAA
     RQAIVEKFAV LLEEHKAELT AVIARETGKP RWEAATEVTA MINKIAISIK AYHARTGEQT
     SELADGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLIFKPS ELTPWTGETV
     IKLWERAGLP AGVLNLVQGG RETGHALSLL DDLDGLLFTG SASTGYQLHR QLSGQPKKIL
     ALEMGGNNPL IIEDAEDIDA AVHLTLQSAF ITAGQRCTCA RRLLVKQGVQ GDAFLARLVD
     VAGRLQPGRW DDDPQPFIGG LISAQAAQHV IEAWHQREAL GGRTLLAPRK VKEGTSLLTP
     GIIELTGVTD VPDEEVFGPL LSVWRYDHFD EAIHLANSTR FGLSCGLVST DRAQFEQLLL
     EARAGIVNWN KPLTGAASTS PFGGVGASGN HRPSAWYAAD YCAWPMATLE SPELTLPATL
     SPGLDFSRRE AV
//