ID   SURE_BORPD              Reviewed;         252 AA.
AC   A9IP06;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   04-NOV-2026, entry version 87.
DE   RecName: Full=5'-nucleotidase SurE {ECO:0000255|HAMAP-Rule:MF_00060};
DE            EC=3.1.3.5 {ECO:0000255|HAMAP-Rule:MF_00060};
DE   AltName: Full=Nucleoside 5'-monophosphate phosphohydrolase {ECO:0000255|HAMAP-Rule:MF_00060};
GN   Name=surE {ECO:0000255|HAMAP-Rule:MF_00060};
GN   OrderedLocusNames=Bpet2549;
OS   Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448 / CIP
OS   107267 / Se-1111R).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC   Burkholderiales; Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=340100;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-461 / DSM 12804 / CCUG 43448 / CIP 107267 / Se-1111R;
RX   PubMed=18826580; DOI=10.1186/1471-2164-9-449;
RA   Gross R., Guzman C.A., Sebaihia M., Martin dos Santos V.A.P., Pieper D.H.,
RA   Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V.,
RA   Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S.,
RA   Linke B., Meyer F., Mormann S., Nakunst D., Rueckert C.,
RA   Schneiker-Bekel S., Schulze K., Voerholter F.-J., Yevsa T., Engle J.T.,
RA   Goldman W.E., Puehler A., Goebel U.B., Goesmann A., Bloecker H., Kaiser O.,
RA   Martinez-Arias R.;
RT   "The missing link: Bordetella petrii is endowed with both the metabolic
RT   versatility of environmental bacteria and virulence traits of pathogenic
RT   Bordetellae.";
RL   BMC Genomics 9:449-449(2008).
CC   -!- FUNCTION: Nucleotidase that shows phosphatase activity on nucleoside
CC       5'-monophosphates. {ECO:0000255|HAMAP-Rule:MF_00060}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside +
CC         phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00060};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00060};
CC       Note=Binds 1 divalent metal cation per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00060};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00060}.
CC   -!- SIMILARITY: Belongs to the SurE nucleotidase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00060}.
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DR   EMBL; AM902716; CAP42891.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9IP06; -.
DR   SMR; A9IP06; -.
DR   STRING; 94624.Bpet2549; -.
DR   KEGG; bpt:Bpet2549; -.
DR   eggNOG; COG0496; Bacteria.
DR   OMA; AAEHWGP; -.
DR   Proteomes; UP000001225; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008254; F:3'-nucleotidase activity; IEA:TreeGrafter.
DR   GO; GO:0008253; F:5'-nucleotidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004309; F:exopolyphosphatase activity; IEA:TreeGrafter.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   FunFam; 3.40.1210.10:FF:000001; 5'/3'-nucleotidase SurE; 1.
DR   Gene3D; 3.40.1210.10; Survival protein SurE-like phosphatase/nucleotidase; 1.
DR   HAMAP; MF_00060; SurE; 1.
DR   InterPro; IPR030048; SurE.
DR   InterPro; IPR002828; SurE-like_Pase/nucleotidase.
DR   InterPro; IPR036523; SurE-like_sf.
DR   NCBIfam; NF001489; surE; 1.
DR   NCBIfam; NF001490; surE; 1.
DR   NCBIfam; TIGR00087; surE; 1.
DR   PANTHER; PTHR30457; 5'-NUCLEOTIDASE SURE; 1.
DR   PANTHER; PTHR30457:SF12; 5'_3'-NUCLEOTIDASE SURE; 1.
DR   Pfam; PF01975; SurE; 1.
DR   SUPFAM; SSF64167; SurE-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Metal-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..252
FT                   /note="5'-nucleotidase SurE"
FT                   /id="PRO_1000091986"
FT   BINDING         8
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00060"
FT   BINDING         9
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00060"
FT   BINDING         39
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00060"
FT   BINDING         91
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00060"
SQ   SEQUENCE   252 AA;  26454 MW;  B1E29DB6D4461C51 CRC64;
     MRILVSNDDG YTAPGLEALV QALQGLGELT VVAPETNHSG ASNSLTLNRP LTVRTAANGF
     ICVNGTPSDC VHVALTGLMD TRPDLVVSGI NNGANMGDDT LYSGTVAAAA EGYLFGIPAI
     AFSLAEKGWA HIEAAARVAR QVVERQVAQQ LAAPVLLNVN IPSRPFEAMA GLQVTRLGKR
     HPSEPVVRTT TPYGDTVYWI GPVGLAADAA PGTDFHAVAQ GAVSVTPLRL DLTQHSQLDE
     VRRWAEPLCA SL
//